week 9 - when cell signalling goes wrong Flashcards
modes of transmission - cholera
water
food
features of cholera
gram-negative bacteria
2 chromosomes
asporogenous
curved rod
ferments glucose, sucrose and mannitol
cholera entry point
the mouth
cholera colonisation point
the small intestine
cholera disease symptoms
diarrhoea
vomiting
muscle cramps
acidosis
hypovolemic shock
cholera exit point
litres of fluid
function of crypt cells
crypt cells actively secrete electrolytes, leading to water secretion
what do mutations in port-oncogenes and tumor suppressor genes lead to
frequently lead to cellular transformation cancer development
what is the most frequently altered gene in human cancer
p53
what does p53 cause
causes cell cycle arrest as it is a transcriptional regulator
what does p53 stop
stops the transition from G1 phase to S phase until the cell knows what to do
target genes - p53
CKIs (inhibitory proteins)
do non-acute retroviruses carry oncogenes
no
do acute transforming viruses carry oncogenes
yes, viral oncogenes
do acute or non-acute induce tumours quicker
acute viruses induce tumours rapidly, non-acute viruses induce tumours more slowly
