week 10 - limb development Flashcards
1
Q
how is limb development progressive
A
structures appear gradually
proportions change
highly regulated
highly homologous
2
Q
initial outgrowth points
A
induced from flank mesoderm
FGF signal is key
3
Q
what transcription factors do target genes include
A
tbx 4
tbx 5
brachyury (T)
4
Q
apical ectoderm ridge structure
A
AER and ectoderm-derived structure
5
Q
what is the apical ectoderm ridge important for
A
signalling centre
6
Q
apical ectoderm ridge function
A
supplies FGF signals to maintain outgrowth
