Week 9 - GHB, Inhalants

Question 1

Briefly explain the natural synthesis of GHB

Answer 1

a

Question 2

How can you produce GHB exogenously (from its pro-drugs)

Answer 2

a

Question 3

What is the main way to administration method?

Answer 3

a

Question 4

How many receptors do we known that GHB works on?

Answer 4

a

Question 5

How is GHB taken back into the brain?

Answer 5

a

Question 6

Why does GHB in the brain half a shorter half-life than GHB in the rest of the body?

Answer 6

Rapid degradation of GHB into GABA in the brain.

Question 7

Where are GHB receptors found predominantly? Where in the brain are GHB’s most common actions?

Answer 7

a

Question 8

How does GHB influence dopamine levels?

Answer 8

a

Question 9

What are GHB’s time-dependent subjective effects?

Answer 9

a

Question 10

How does GHB influence sleep waves and sleep in general?

Answer 10

a

Question 11

What are inhalants? What different drugs does this label include?

Answer 11

a

Question 12

What are most of the abused inhalants?

Answer 12

Volatile Solvent: toulene, xylene, butane, ethylene

Question 13

How are inhalants generally administered? ie. what are sniffing, huffing, bagging?

Answer 13

a

Question 14

What are the pharmacodynamics of inhalants (specifically toluene)?

Answer 14

a

Question 15

What are the acute effects of toluene?

Answer 15

a

Question 16

What are the chronic effects of toluene?

Answer 16

a

Question 17

How is toluene thought to influence dopamine levels?

Answer 17

a

Question 18

What is the staircase paradigm?

Answer 18

a

Question 19

What does stage 1 of inhalant use involve?

Answer 19

a

Question 20

What does stage 2 of inhalant use involve?

Answer 20

a

Question 21

What does stage 3 of inhalant use involve?

Answer 21

a

Question 22

What does stage 4 of inhalant use involve?

Answer 22

a

Question 23

What are drug discrimination studies and what are they used for?

Answer 23

a

Question 24

What is the positive modulation of GABAa receptors thought to be responsible for when under the influence of toluene?

Answer 24

a

Question 25

What does chronic toluene use result in?

Answer 25

a