Week 8 Flashcards
what effect can diabetes have on the GI?
In some cases of longstanding diabetes, the enteric nerves supplying the small intestine may be affected, leading to abnormal motility, secretion, or absorption. This leads to symptoms such as central abdominal pain, bloating, and diarrhea. Delayed emptying and stagnation of fluids in the small intestine may lead to bacterial overgrowth syndromes, resulting in diarrhea and abdominal pain.
Metclopropamide and cisapride may help to accelerate the passage of fluids through the small intestine, whereas broad-spectrum antibiotics will decrease bacterial levels.
How to differentiate gout or pseudo gout with septic arthritis?
Obtain athrocentesis
gout - yellow, parallel, needle shaped
pseudogout - rhomboid, parallel is blue
*could see neutrophils from acute inflammation*
vs septic arthritis, likely to see culprit!
S. aureus, Strep or N. gonorrhea
what area of the brain does the ACA supply?
Stroke here –>
anterior-medial surface (could see in a midsaggital cut)
lesion –> contralateral lower limb paralysis and loss of contralateral lower limb sensation
viral particle with wheel like shaped?
What symptoms could this cause in a young child/infant?
double-stranded RNA, segmented, naked w/icosahedral capsid
Disease - #1 cause of severe infantile gastroenteritis that leads to watery diarrhea
ABG metabolic ketoacidosis?
METABOLIC acidosis –> bicarbonate will be low
increased anion gap
INC H+ / hyperventalation will compensate (decreasing PCO2)
** insulin normally shifts potassium in - lack of, plus acidosis, shifts potassium out of cell –> hyperkalemia but depleted totaly body K+ ..and eventually will be lost in urine –> part of treatment includes giving potassium
Recurrent vomiting ABG?
vomiting = expelling hydrogens –> metabolic ALKALOSIS
HCO3- INC
pH increased
Anion gap is normal
K+ decreased (in alkalosis, K+ shifts into the cells –> decreased K+)
what are the calories per gram of fats, proteins and carbs?
fats: 9 calories/gram
proteins: 4 calories/gram
carbs: 4 calories/gram
alcohol: 7 calories/gram
*Calories = Kcal = 1000 calories
What murmur could be described as brisk with a rapid fall?
aortic regurg
leukocytes vs lymphocytes vs myeloid cells?
leukocytes = white blood cells (not RBCs)
Lymphocytes = T cells, B cells, Natural killers (part of innate)
Rest are myeloid origin - includes: of myeloblast origin:neutrophils, basophils, eosinophils, monocyte/macrophage
Anestetics - what does it mean to have increased/decreased blood vs lipid solubility?
drugs with DECREASE solubility in BLOOD –>
rapid induction and rapid recovery
drugts with INCREASE solubility in LIPIDS–>
increase potency = 1/MAC (minimal alveolar concentration-in inhaled; amt required to prevent 50% of its subjects from moving in response to noxious stimuli)
what is pseudocholinesterase?
glycoprotein enzyme made by the liver to hydrolyze/deactive exogenous choline esters
ppl with a defect in this enzyme have higher levels of succinylcholine –> neuromuscular blockade by succinylcholine neurmuscular blocks
provide artificial ventilation until pt wakes up; no further medical complications have been noted
where are the most actively dividing cells in the GI found?
base of crypt
Fluoroquinoloes (-floxicans) should not be taken with what other drugs?
do not take with anti-acids!
(aluminum hydroxide, calcium carbonate, magnesium hydroxide)
*Tetracyclines also should not be taken wtih milk, anti-acids or iron containing preparations because it will decrease the bioavailability of the drug in the gut
polycystic kidney disease with clear kideny damaged ABG?
INC in BUN, INC in creatine, with a ratio <15 –> intrinsic renal failure –> metabolic acidosis
low pH and low bicarb
low PCO2 to compensate
What marker should be used to monitor heparin?
an increase of tihs marker could be an indication of what?
use PTT (partial thrombinplastin time-intrinsic pathway)
Heparin induced thrombocytopenia (HIT) = development of IgG antibodies against heparin boudn platelet factor 4
Ig-heparin-PF4 complex activates platelets –> thrombosis and thrombocytopenia
No neutrophils at infection site, yet enough in the blood + mulitple skin and mucosal infections?
LIkely to be leukocyte adhesion deficiency type 1 -defect in LFA1-integrin CD18 protein on phagocytes –> impaired migration and chemotaxis
Auto recessive
also associated with: absent pus formation, impaired wound healing and delay umbilical cord separation (>30days)
person with hemochromatosis is at increased risk for what disease processes?
HCC
also results in HF and testicular atrophy
primary is autosomal recessive
secondary could be do to excessive transfusions
Atelectasis-
what is it? what does it cause and what could precipitate it?
atelectasis = alveolar collapse –> bronchial obstruction
on lung exam: decreased breath sounds, dull to percussion, decreased fremitus, and if there is tracheal deviation, it wil be towards the affected side
causes:
- compression (usually an accumulation of fluid/blood/air that physically compress/collapse the adjacent lung) examples are pleural effusions from HF, typically reversible
- Resportion (when air is blocked from reaching the alveoli) examples are obstruction of bronchus by mucopurulent plug; typically reversible
- Contraction (occurs when local or generalized fibrotic changes in the lung/pleura hamper expansion and increase elastic recoil during expiration) example radiation therapy; typically irreversible
fingershaped fibrovascular core with benign squamous cell epithelium on vocal cords or epligottis?
think HPV 6
Dry tap?
think: aplastic anemia (hypocellular) or myelofibrosis (fibrotic)
myelofibrosis–> tear drop cells
=obliteration of bone marrow due to increase fibroblast activity in response to proliferation of monoclonal cell lines
see tear drop RBC and immature forms of the myeloid line (ie-nucleated erythrocytes)
often associated with massive splenomegaly
NOT associated with the philadelphia chromosome but in 30-50% of the cases with a JAK2 mutation
left lower sternal border holosystolic murmur?
ventricular septal defect
leukamoid reaction:
acute inflammatory response to infection
increase WBC with increase neutrophils and increase precursors such as band cells (left shift)
increase LAP (leukocyte alkaline phosphatase - in contrast to CML which as a decrease LAP)
melanoma - what affects its prognosis?
significant risk for metastasis
DEPTH correlates with risk
pulmonary hypertension is mostly idipathic but can be secondary to..
fibrosis
fibrosis –> deoxygenation –> vasoconstriction via endothelin-1
tx: bosentan (endothelin-1 antagoinst –> decreasing vascular resistance), PDE inhibitors, prostaglandin analogs (PGI1 - epoprestinol, iloprost)
*pulmonary sclerosis is the most common cause of death in people with scleroderma*