WEEK 8 Flashcards
… is the best penetration enhancer
Hydration
T or F
Niosomes are colloidal particles.
F
Liposomes are
Why are liposomes ability to administer medication through the skin is debatable?
Liposomes generally accumulate in the SC and are not expected to penetrate into viable skin.
… are special liposomes that incorporate surfactants (e.g. sodium cholate).
Transferosomes
Which vesicles are claimed to be ultra-deformable and require a hydration gradient to drive the transferosome from the skin surface towards more hydrated viable layers?
Transferosomes
…. are soft vesicles composed mainly of phospholipids
Ethosomes
… are composed of nonionic surfactants and cholesterol
Niosomes
Which type of vesicles can enclose aqueous or lipophilic drugs in their core?
Niosomes
T or F
Nanoparticles and dendrimers are also proposed to promote transdermal drug delivery
T
Why are macromolecules not suitable for oral administration?
- Their large molecular sizes and high degrees of polarity make them impermeable
via the intestinal epithelium. - They are highly susceptible to inactivation in the gastrointestinal tract by several degradation enzymes
T or F
The human skin is positive charged under normal physiological conditions
F
Negatively charged
T or F
Iontophoresis typically uses a current of an amplitude which doesn’t induce adverse effects
T
T or F
Iontophoresis can’t be used to promote permeation of drugs difficult to get across the SC such as charged and hydrophilic molecules
F
It can
T or F
Aspirin is equivalent in effectiveness to anticoagulants in preventing venous thrombosis in patients who have had a total knee or hip replacement.
T
What does NOACS stand for?
novel oral anticoagulants
