WEEK 2: Manufacture and Dissolution

Question 1

A well made tablet has what 4 characteristics?

Answer 1

Free from defects
Able to withstand handling
Chemically, physically and microbiologically stable
Able to release the active pharmaceutical ingredient (API) predictably and reliably

Question 2

T or F
When an excipient is used in a tablet formulation its sole purpose is to aid the manufacturing process

Answer 2

F
excipients are
required for both the manufacturing process as well as the therapeutic performance of the tablet.

Question 3

What might excipients be used for in the manufacturing process of drugs?

Answer 3

Binder, filler, disintegrant, glidant, lubricant, preservatives, colours and flavours

Question 4

What types of medication dosage forms are usually high in binder excipients?

Answer 4

Lozenges and implantable tablets

Question 5

Why might a lubricant excipient be added to a tablet formulation?

Answer 5

Lubricants may be required for reducing friction immediately after compression so the tablet can be easily ejected from the die cavity without sticking to the cavity wall

Question 6

API’s that are sensitive to … or … might have to be processed through dry granulation.

Answer 6

moisture or heating

Question 7

T or F
Only immediate release medications undergo dissolution

Answer 7

F
All dosage forms undergo this process regardless of whether they are immediate release, extended release or delayed release in nature.

Question 8

The process of dissolution can be mathematically described by the … equation.

Answer 8

Noyes-Whitney