Week 7-Psychological Therapy for Pain (incl. mindfulness) Flashcards

1
Q

Define mindfulness

A

Intentional, non-judgmental focus on the present moment (Shapiro et al., 2006)

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2
Q

What is the history of mindfulness techniques?

A

Formal Meditation Practises:
1. Mindfulness Based Stress Reduction
(MBSR) (Kabat-Zinn, 1985): for those with chronic conditions

  1. Mindfulness Based Cognitive Therapy
    (MBCT) (Segal, Williams, & Teasdale, 2002): evolved from the technique above, aimed to prevent the relapse of depression by building psychological resilience

Other exercises that promote mindfulness:
1. Acceptance and Commitment Therapy (ACT) (Hayes, Luoma, Bond, Masuda, & Lillis, 2006): Like CBT but with mindfulness as a core component. Does contain some formal meditation practises, but also contains other exercises such as visualisation or mental imagery type exercises which promotes mindfulness.

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3
Q

What are the Commonalities between MBSR and MBCT? (Day et al., 2014)

A

 Both group setting interventions consisting of 4 to 8 weekly sessions.

 Both provide guided mindfulness meditation audio files and are instructed to practice daily for 45 minutes.

 Both use practice progression (i.e., build on mindfulness): body scan, seated meditations, mindful movement/yoga/walking, sharing experiences.

 Both encouraged to infuse mindful practices into everyday tasks e.g., mindfulness in showering, eating, brushing teeth etc.,

-Almost no differences between the two

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4
Q

What are the Advantages of mindfulness meditation?

A

 Just as effective as CBT and hypnosis

 Additionally, suitable for delivery in large groups (in uncomplicated cases)

 Can be delivered via internet or apps

 Many opportunities for ongoing support (e.g., meditation retreats)

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5
Q

What are the Disadvantages of mindfulness meditation?

A

 Requires preparedness of the patient (needs awareness that their mental state impacts their life and must be willing to do something about it)

 “McMindfulness” (hype, over-marketing,
unrealistic expectation), need to set realistic expectations of the outcomes following mindfulness meditation

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6
Q

What’s the IAA model of mindfulness? (Shapiro et al., 2006)

A

-Intentional, non-judgmental [Attitude] focus [Attention] on the present moment

Intentions (i.e., reasons why one might want to practise mindfulness):
1. Self-regulation (behaviour/symptom change)
2. Self-exploration (curiosity)
3. Self-liberation (spiritual-i.e., overcoming self-concern at the expense of other people)

(non-judgemental) Attitude (qualities of attention/intention):
1. Open/accepting to experiences
2. Kindly
3. Curious

Attention:
1. Shifting attention away from mental processes and any occuring ruminations
2. Sustaining attention in the present moment

-All these components interrelate and interact with each other

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7
Q

IAA: What’s Decentring as a “meta-mechanism”? (Shapiro et al., 2006)

A
  • Decentring or as Shapiro terms Re-perceiving, is a core component of mindfulness (originating from MBCT)

“Subject” becomes “Object” of attention e.g., mental events such as sensations

  • ACT: Cognitive de-fusion (and “self-as-context”)

-These IAA components don’t necessarily drive therapeutic change

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8
Q

What’s Acceptance and Commitment Therapy (ACT)?

A

■ “ACT is a therapeutic approach that uses
acceptance and mindfulness processes (mindfulness components), and
commitment and behaviour change processes (CBT components), to produce greater psychological flexibility.” (Hayes, Wilson, Strosahl, 1999)

■ ACT is an evolution of Cognitive-Behavioural Therapy, with the key difference between the incorporation of mindfulness practices (McCracken and Vowles, 2014)

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9
Q

What’s The ACT Hexaflex? (Hayes, Strosahl & Wilson, 1999)

A

-It is a 6 component model of ACT

Psychological flexibility is linked with:
-Contact with the present moment
-Values
-Acceptance
-Cognitive Defusion
-Committed Action
-Self as Context

Acceptance and mindfulness approaches include:
-Contact with the present moment
-Acceptance (i.e., non-judgemental)

Commitment and behaviour change processes include:
-Values e.g., reduce pain, spend more time with family
-Committed action as a result of those values

Decentring includes:
-Defusion
-Self as Context

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10
Q

ACT Hexaflex: What is involved in the “Decentering” Process?

A

Bennett et al. (2021):
* “Allows individuals to experience distressing inner events as imperfect
models of the real-world rather than
precise reflections.”

  • Article provides up-to-date overview
    of different models and methods to
    measure decentring; takes developmental perspective as this ability tends to develop between 10-13 years of age (Example: McCracken, et al., 2014).

Decentring has a two-factor structure ( McCracken, et al., 2014):
(1) Self-as-context - intentionally
disengage/disidentify from the content
of inner events
(2) Cognitive defusion - reduced
emotional reactivity to those events

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11
Q

What are some Key learning points?

A

■ Mindfulness is a well-defined construct, but implemented differently in different therapeutic models, and with different terminology.

■ The IAA model captures both the definition and core qualities of mindfulness; Decentring is the core cognitive mechanism.

■ The ACT model: Mindfulness is core, but supplemented by values clarification and committed action and is therefore more focused on behaviour change.

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12
Q

What are Specific and non-specific therapeutic components of drug therapies and psychotherapies? (Enck and Zipfel, 2019)

A

-Non-specific components are part of psychotherapies which are common in the control condition and therapeutic clinical condition

-Control/Placebo conditions if proper, will control for things like the regression to the mean, natural course of disease and methodological biases

-There are specific components which move past the control condition such as common factors (factors you would expect to improve as a result of any psychological intervention). These components are common across various psychological interventions. It could include therapist relationship, trust, empathy etc., which would impact the factors like conditioning and expectations in placebo conditions (the better the relationship the more likely the patient expects it to be positive)

-There are also effects specific to the therapy which are things that differ between therapeutic models e.g.,, the difference between IAA and ACT

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13
Q

How does mindfulness and placebo have theoretically distinct cognitive mechanisms?

A

■ Expectation:
– Placebo relies on the cognition fusion of expectations with reality (internal model of the world-dominating over the senses) i.e., getting in your head
– Mindfulness aims for cognitive de-fusion (“coming to your senses”) i.e., getting out of your head

■ Conditioning:
– Placebo relies on conditioning mechanisms to induce pain relief
– Mindfulness aims to recognise / bring awareness to the person’s conditioning history to undermine conditioned responses (e.g. acceptance of pain undermines threat-related conditioning)

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14
Q

What is the Specific effectiveness of mindfulness on pain above a simple placebo effect: study designs

A
  • Active control conditions are crucial for filtering out non-specific effects, notably the placebo effect (expectation of benefit, not the treatment itself)
  • Most active controls in mindfulness studies were not other established treatments, but rather minimally effective interventions (“shams”) i.e., teaching them something else, getting everything apart from the specific components

Study types:
Acute pain:
Short-term effects
* Randomised clinical trials
* Sham controlled studies available
Long-term effects
* Between-subject designs available
* Longitudinal designs not available
* Sham control impossible (not ethical)

Chronic pain:
Short-term effects
* Randomised clinical trials
* Few studies using sham controls
Long-term effects
* Lack of published data

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15
Q

What are the short-term effects of
mindfulness on acute pain beyond simple placebo effects?

A

■ Effect on pain unpleasantness and
importance of sham control condition(s)

■ Do placebo effects contribute to
mindfulness-based analgesia?

■ Physiological correlates (brain imaging,
pharmacological studies) may distinguish
mindfulness from sham or placebo

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16
Q

Mindfulness is placebo based: Do placebo effects contribute to mindfulness-based analgesia? (Davies et al., 2022)

A

■ Acute experimental pain study outcome variables:
– pain intensity and unpleasantness
– pain threshold and tolerance
– psychological and physiological mediators

■ Sham control conditions are needed to identify specific effects vs. placebo effects
– Most trials on mindfulness for acute pain lack these controls!
– Both mindfulness and sham interventions reduce pain intensity and unpleasantness
– But mindfulness might be superior in reducing pain unpleasantness

■ Psychological mediators indicate mindfulness effects are mainly placebo-related:
– Expectancy of receiving a mindfulness intervention mediated changes in pain unpleasantness and tolerance in both interventions.
– Mindfulness-related processes (increases in nonjudging and nonreactivity), did not mediate effects on pain unpleasantness.
-This evidence indicates that placebo effects may play a more dominant role for acute pain and changes are driven by expectation.

17
Q

Mindfulness is not Placebo based: What’s the difference between Mindfulness Versus Placebo Analgesia in terms of brain activations? (Zeidan et al., 2015)

A

■ fMRI study; 4 day mindfulness intervention compared to sham meditation and placebo analgesia.

■ Mindfulness meditation reduced pain intensity and unpleasantness ratings more than sham mindfulness or placebo

■ Mindfulness meditation produced distinct patterns of pain-related brain activation from sham mindfulness and placebo analgesia

– vs. placebo: greater activation in brain regions associated with the cognitive
modulation of pain (orbitofrontal, subgenual anterior cingulate, and anterior
insular cortex).

– vs. sham: greater activation in the right
putamen/globus pallidus and the posterior cingulate cortex; less activation in the
thalamus, PAG, bilateral DLPFC compared to the sham.

-Therefore the effects of mindfulness are unique and different to placebo analgesia (although brain scans are difficult to interpret)

18
Q

Mindfulness is not placebo based: What evidence is there supporting the idea that Mindfulness analgesia is not opioid-mediated? (Zeidan et al., 2016)

A

Double-blind, randomized psychophysical study

■ Noxious heat stimulation

■ Short-term mindfulness meditation (after 4 separate days (20 m/d) of practice) during naloxone or saline administration

-Paper concludes that mindfulness analgesia is NOT opioid-mediated

-Combined with the brain imaging data, the physiology of mindfulness suggest a different mechanism of mindfulness vs. placebo

-Mindfulness had a 40% reduction in pain intensity

-Naloxone was administered following mindfulness. This is an opioid antagonist meaning if mindfulness was opioid-mediated, it would have increased back to the original pain intensity as mindfulness would no longer be effective if opioid receptors are blocked. However no effect was seen highlighting that mindfulness is not opioid-mediated.

19
Q

What are the short-term effects on Chronic Pain?

A

Mindfulness / acceptance-based therapies
improve emotional functioning more than pain and physical functioning.

20
Q

What did a meta-analysis on mindfulness-
based interventions (MBIs) find in chronic pain conditions? (Sharpe et al., 2023)

A

■ Generally, MBIs show efficacy compared to passive controls, especially in certain chronic pain conditions: fibromyalgia, low back pain, headache/migraine pain.

■ MBIs are equal to other treatments like CBT, but not superior.

■ Large effect on pain severity and small effect on anxiety, but not enough evidence on reducing pain-related disability.

Research Gaps & Recommendations:
■ Need more well-controlled studies with larger samples and active control conditions.
■ Insufficient evidence to recommend MBIs as a “first-line” treatment for chronic pain.

21
Q

Chronic pain meta-analysis: What was found regarding Mindfulness and acceptance interventions? (Veehof et al., 2016)

A

■ 25 RCTs totalling 1285 patients with chronic pain

■ Mixture of designs, comparing intervention to waiting list, treatment-as-
usual, and education or support control groups

■ Improvements in pain, pain interference, quality of life, anxiety and depression

Outcomes at follow-up (2 to 6 months):
* Pain interference (n=2): 1.05
* Quality of life (n=7): 0.66
* Anxiety (n=4): 0.59
* Depression (n=10): 0.53
* Pain intensity (n=10): 0.41
* Disability (n=5): 0.39

22
Q

Chronic pain meta-analysis: What was found regarding Mindfulness meditation (no ACT)? (Hilton et al., 2017)

A

■ 30 RCTs totalling 3536 patients with
chronic pain (migraine, headache, back
pain, osteoarthritis, or neuralgic pain)

■ Mixture of designs, comparing intervention to treatment as usual, waitlists, no treatment, or other active treatments

■ Improves pain, but more greatly improves mental and physical health-related quality of life

Outcomes at follow-up:
* Mental health QoL (n=16): 0.49
* Physical health QoL (n=16): 0.34
* Pain (n= 30): 0.32
* Disability (n=4): 0.30
* Depression (n=12): 0.15

23
Q

Chronic pain meta-analysis: What was found regarding MBSR/MBCT? (Bawa et al., 2015)

A

11 studies Chronic pain conditions
included:
– fibromyalgia
– rheumatoid arthritis
– chronic musculoskeletal pain
– failed back surgery syndrome
– mixed aetiology

Outcomes:
* Pain acceptance (n=2): 1.58
* Sleep quality (n=2): 1.32
* Perceived pain control (n=2): 0.58
* QOL: mental health (n=4): 0.37
* Physical functioning (n=5): 0.22
* QOL: physical health (n=4): 0.16
* Pain intensity (n=8): 0.16
* Depression (n=6): 0.12
* Anxiety (n=2): 0.10
* Mindfulness (n=4): 0.03

24
Q

Chronic pain meta-analysis: What was found regarding pain management programmes (holistic)? (Elbers et al., 2022)

A

■ Treatment of choice for chronic pain

■ Combine cognitive-behavioural approaches (incl. mindfulness) with
exercise, medical treatment and education based on a biopsychosocial model.

■ 58 RCTs totalling 3536 patients with
chronic primary musculoskeletal pain

■ Improvements in pain and pain
interference in daily activity, but more
so for quality of life outcome such as
emotional and social functioning, and also self-efficacy

Outcomes at follow-up
* Self-efficacy (n=11): ES=0.85
* Social functioning (n=8): ES=0.71
* Emotional functioning (n=11): ES=0.62
* Pain interference (n=53): ES=0.53
* Pain intensity (n=55): ES=0.45
* Physical function (n=20): ES=0.43
* Depression (n=41): ES=0.42
* Anxiety (n=19): ES=0.32
* Anger (n=1): ES=0.49

25
Q

Mindfulness and chronic pain: What is the pain physiology? (Brown & Jones, 2013)

A

 Increases in the anticipation of pain in the dorsolateral PFC (dlPFC) predict greater perceived control over pain – Improvements in executive control / descending inhibition? Distinct from mindfulness effects on acute pain

 Decreased anticipation in the ventromedial prefrontal cortex (vmPFC) and
supplementary motor area (SMA).

26
Q

What are the Long-term effects of mindfulness on acute pain?

A

■ Limited to observational studies (not randomised designs)

■ “Expert” mindfulness practitioners experience less pain unpleasantness

■ Distinct brain activation patterns in “expert” practitioners
– Decreased anticipation, increased pain
processing
– Engagement of brain regions associated with placebo analgesia and endogenous opioid release

27
Q

What are the typical study designs used for mindfulness?

A

■ Existing studies are observational (non-randomised) between-subjects designs involving “expert” meditators (years of practice)

■ Control group might be either:
– Entirely naïve to mindfulness practice
– “Novice” mindfulness practitioners

■ Lack of longitudinal studies (e.g. cohort studies, randomised studies) that follow-up participants after many years.
– Designing a convincing sham mindfulness intervention that remains believable and ethical over the long term would be challenging
– Cost and resource-intensive
– High attrition rates

28
Q

What is acute pain like in experienced meditators? (Brown & Jones, 2010) *

A

 Pain unpleasantness is reduced, but only in the most experienced meditation practitioners (> 6 years), otherwise no effect seen when looking at all meditators.

 We hypothesised this was because they anticipated pain less (due to greater focus on the present moment)

 Mid-cingulate cortex decreased during
anticipation of pain in meditators

 Decrease related to less unpleasantness

Physiology of mindfulness:
 Greater perigenual anterior cingulate cortex (pACC) / medial prefrontal cortex (mPFC) activity during anticipation of pain

 Greater activity correlated with less
unpleasantness in meditation group

 Opposite correlation in control group!

29
Q

What is acute pain like in experienced mediators? (Lutz et al., 2013)

A

 Findings confirmed in fMRI study: reduced activation of MCC and insula during anticipation of pain

 But, MCC and insula increased during pain experience

-It’s not that these people who practise mindfulness are suppressing the pain itself rather they aren’t anticipating it as much.

30
Q

What was found during the investigation of Acute pain anticipation during “insight” meditation? (Gard et al., 2011)

A

 Greater pACC/mPFC activity during anticipation of pain while participants were meditating (fMRI study)

31
Q

What was found when investigating Brain activation during focused attention meditation? (Hölzel et al., 2007)

A

 Greater pACC/mPFC activity in experienced vs. novice meditators

 In this study, no pain was administered.

 Hence, greater activation can occur voluntarily and without a stimulus in experience meditators

32
Q

Physiology of placebo: Is mindfulness
just a placebo effect? (Petrovic et al., 2002)

A

 Greater pACC/mPFC activity in both placebo analgesia and opioid analgesia

 Placebo analgesia is opioid-mediated

 If mindfulness analgesia is activating pACC/mPFC then it may share opioid mechanisms with placebo, however…

 We lack convincing evidence of opioid-mediated effects of mindfulness

33
Q

What is the prevalence of Chronic Pain? (BBC News, 2022)

A

-1 in 4 adults live with chronic pain

-24% of these people take opioid painkillers

-23% of these people are on a waiting list for surgery or pain management programmes

 Accounting for 15% to 20% of physician
visits.

 12% have severe, disabling symptoms.

 One of the largest costs to the NHS.

 Average of 7-9 years of pain before they
present in pain services.

34
Q

What is the Treatment Journey?

A
  1. Looks for treatment
  2. Hopes are up
  3. Treatment doesn’t work entirely or has long-term effects
  4. Difficult relationship with doctors = disappointment

-Life is continually on hold

35
Q

What are key points to consider when managing the impact of pain?

A
  1. Medication
  2. Goal setting towards things that matter
  3. Friends and family day, relationships and communication
  4. Sleep
  5. Doing activities differently
  6. Approaching barriers differently using mindfulness skills to change your relationship with difficult stuff
36
Q

What are the key models of psychological therapy for pain?

A
  1. ACT
  2. Biopsychosocial model
  3. CBT
  4. Pain Avoidance Model (aims to decondition)
37
Q

What’s the evidence for the evaluation of pain management programmes?

A

 Pain management promotes behaviour change and improves wellbeing in people with pain and is traditionally delivered to groups of individuals

 There is high-level evidence for the efficacy of both outpatient and residential
PMPs (Williams 1999, 2012, Guzman 2001, Van Tulder 2000)

 A number of systematic reviews have shown that PMPs significantly reduce
distress and disability, enhance coping and improve various measures of physical functioning (Guzman 2001, Van Tulder 2000, Watson 2004).

 Cost-effective (Gatchel 2006, Turk 2002, 1998)

 Most programmes are grounded within the biopsychosocial model of chronic pain and use principles of Cognitive Behavioural Therapy and Acceptance and Commitment Therapy

38
Q

How can pain management programmes not be suitable for everyone? (especially group-based ones)

A

 Entrenched anger/ hostility/ irritability to others (Eccleston, 2001)

 Active, untreated PTSD

 Poor locus of control and high expectations that others will/ should fix them (Meredith et al., 2007)

 Poor psychological flexibility

 Extremely avoidant/ high levels of fear re: thinking about emotions (opening the box)

 Functioning relatively well: validation, 1:1 support (extended assessment, MDT therapy).

 Options: preparation, onward recommendations, re-referral

39
Q

What were the PMP Outcomes (2021 Audit)?

A

 Significant change between assessment, reassessment and at follow up for all measures. Pain intensity = smallest shift.

 All measures surpassed expected benchmark (Fenton & Morley, 2013)

 Significance is great but how much do patients improve (Clinically Significant Change, CSC).
- Mood 43%
- Pain Related Catastrophising 48%
- Self-Efficacy 59%
- Meaningful activity 76-91%
- GP visits 46 %
- Sit to Stand 42%

 Satisfaction 81% extremely likely to recommend. 94% would recommend to family and friends.