Week 7 Flashcards
Etiology: COPD
smoking (primary), air pollution, second-hand smoke, Hx of childhood resp infxs, occupational pollutant exposure, autoimmunity, genetic (alpha-1-antitrypsin deficiency), ashthma
SSx (from history): COPD
dyspnea (exercise first, then rest), chronic productive cough (morning to all-day), wheezing, hemoptysis, lower extremity edema, small amount of clear sputum
PE: COPD
barrel chest, Hoover’s sign, pursed-lip breathing, cyanosis, yellowing of fingertips, nail clubbing, weight loss, tripod position
Findings (auscultation): COPD
decreased breath sounds, crackles at lung bases, distant heart sounds
Findings (percussion): COPD
hyperresonant, decreased diaphragmatic excursion
Dx: COPD
PFT, Pulse ox, arterial blood gases, chest CT, alpha-1-antitrypsin level, CXR
Findings (PFT): COPD
decreased FEV1 (decreased flow rate), TLC normal
When FEV1 falls below ___, the lungs are no longer normal.
85% of predicted values
Pathophysiology: emphysema
permanent enlargement of alveolar ducts and air spaces distal to terminal bronchioles; destruction of alveolar walls, elastic recoil, fibrosis, scarring
Etiology: emphysema
smoking, genetic (alpha-1-antitrypsin deficiency)
SSx: emphysema
dyspnea, cyanosis, exercise intolerance, cough (hard, spasmodic, tiring)
PE: emphysema
“pink puffers,” barrel chest, decreased breath sounds, hyperresonance, use of accessory resp. muscles, expiratory crackles/wheezing, PMI deviated toward sternum
SSx: chronic bronchitis
productive cough (worse in mornings, small amount colorless sputum), dyspnea (6th decade), wheezing, tachypnea, “blue bloaters,” anorexia
“Blue bloaters”
cyanosis and fluid retention, right CHF (seen in chronic bronchitis)
PE: chronic bronchitis
increased resp. rate (prop. to severity), use of accessory muscles; advanced dz (cyanosis, elevated JVP, peripheral edema); FET > 6 secs, barrel chest, wheezing, decreased breath sounds, hyperresonance, prolonged expiration, inspiratory crackles
Pathophysiology: chronic bronchitis
hyper-secretion of mucus secondary to hypertrophy of bronchial glands, leading to thickening of bronchial tubes
Primary difference between asthma and COPD
degree of reversibility
pathophysiology (3 main features): asthma
airway obstruction (reversible), inflammation, airway irritability (increased reactivity); manifests as episodes of wide-spread broncho-constriction
Etiology (infants): asthma
foods, emotional upset, atopy, bottle feeding, early weaning, parental smoking
Classifications: asthma
extrinsic (allergic) - d/t allergy to external factors, intrinsic (non-allergic) - d/t infx of upper/lower resp tract, irritants, emotions, exercise, cold weather
SSx: asthma
no sxs between asthmatic episodes, cough (worse at night, w/ exercise), wheezing, dyspnea, chest tightness, sputum
Common triggers: asthma
URIs, inhalant allergens, medications, food, exercise, irritants, weather, emotions, GERD
PE: asthma
tachypnea, tachycardia, diaphoresis, use of accessory muscles, anxiousness
In a patient with asthma, marked weight loss could be indicative of ____
development of severe emphysema
Pulsus paradoxus
exaggerated fall in systolic bp/slowing of pulse rate during inspiration; may occur during acute asthma exacerbation
Findings (auscultation): asthma
end-expiratory high-pitched/polyphonic wheezing, prolonged expiratory phase, diminished breath sounds/chest hyperinflation during acute exacerbation
In a patient with asthma, the presence of inspiratory wheezing (usu expiratory) or stridor may prompt an evaluation of ___
upper airway obstruction (vocal cord dysfunction, vocal cord paralysis, thyroid enlargement, soft tissue mass)
RED FLAG symptoms: asthma
confusion, drowsiness, absent lung sounds, cannot speak, cyanosis, status asthmaticus
Status asthmaticus
unresponsive to routine therapy; severe, prolonged attack that can be suddenly fatal; unremitting attacks
PE (upper airway): asthma
signs of nasal obstruction (polyps, swollen mucosa) which can worsen asthma
PE (skin): asthma
atopic derm, eczema, or other signs of skin conditions (extrinsic asthma)
DDx: COPD
central airway stenosis, bronchiectasis, heart failure, TB, constrictive bronchiolitis
Pathophysiology: bronchiectasis
infx followed by airway obstruction and impaired drainage; permanent damage/dilation of bronchi
Etiology: bronchiectasis
infx (bac/virus/fungal), congenital obstruction, immunodeficiency (IgA, IgG, HIV), abnormal secretion clearance (CF), genetic (alpha-1-antitrypsin deficiency), extrapulmonary cause (RA, Crohn’s, Sjogren’s)
SSx: bronchiectasis
chronic daily cough, daily sputum (mucupurulent, thick), hemoptysis, dyspnea, rhinosinusitis, wheezing, pleuritic chest pain, fatigue
Age of presentation: bronchiectasis, COPD, asthma
bronchiectasis (45 - 60 yo)
COPD (> 60 yo)
asthma (2-20 yo; > 40 yo)
Sex bias: bronchiectasis, COPD, asthma
bronchiectasis (F)
COPD (M)
asthma (none)
Etiology: bronchiectasis, COPD, asthma
bronchiectasis (infx, genetic, immune defect) COPD (cigarette smoking)
asthma (FHx of allergies, following URI)
Role of infx: bronchiectasis, COPD, asthma
bronchiectasis (primary)
COPD (secondary)
asthma (exacerbations)
Predominant organism: bronchiectasis, COPD, asthma
bronchiectasis (H. influenzae, p aeruginosa)
COPD (S. pneumoniae, H. influenzae)
asthma (resp. syncytial virus, parainfluenza virus, rhinovirus, influenza virus)
Airflow obstruction and hyper-responsiveness: bronchiectasis, COPD, asthma
present in all
Quality of sputum: bronchiectasis, COPD, asthma
bronchiectasis (purulent)
COPD (mucoid, clear)
asthma (rare)
Pathophysiology: cystic fibrosis
gene defect (CFTR protein mutation) leading to abnormal production of thick mucus, primarily affecting respiratory and digestive systems
Sex bias: cystic fibrosis
M=F
Dx: cystic fibrosis
stool analysis (steatorrhea), trypsinogen blood test in newborns, sweat chloride test, chest x-rays, PFTs, genetic screen (CFTR mutation)
PE (nose): cystic fibrosis
rhinitis, nasal polyps
Sx (sinuses): cystic fibrosis
panopacification, polyps, chronic rhinosinusitis
Sx (kidney): cystic fibrosis
nephrolithiasis
Sx (musculoskeletal): cystic fibrosis
reduced bone density, clubbing of fingers/toes
Sx (reproductive tract): cystic fibrosis
spermatogenesis defects, amenorrhea, cervical mucus
Sx (liver): cystic fibrosis
cirrhosis, portal hypertension, cholelithiasis
Subtypes of COPD
emphysema, chronic bronchitis, obstructive asthma
COPD is the ___ leading cause of death in America.
3rd
Hoover’s sign
costal margins move inwards w/ inspiration; seen in COPD
Chronic bronchitis cough
occurs most days of the month, 3 mos / year, for 2 years w/o other explanation
Etiology (10-30 yo): asthma
inhalants
Etiology (> 45 yo): asthma
infx
Dx: bronchiectasis
CBC (anemia), sputum culture, PFT (low FEV1), CXR, sweat test
Etiology: laryngotracheobronchitis
parainfluenza type I (60%) infx of upper/lower resp tracts; also parainfluenza II/III/IV, influenza A/B, adenovirus, coxsackie A/B, rhinovirus, measles, HSV, resp syncytial virus
Pathophysiology: laryngotracheobronchitis
resp distress caused by inflammatory response to infx, not infx itself