Week 6: Control of Breathing Flashcards
What are the two types of respiratory centres in the medulla and what are they mainly used for?
Dorsal respiratory group (DRG) which is predominately concerned with inspiration and the ventral respiratory group (VRG) which is predominately concerned with active inspiration and expiration
How does DRG work?
- They produce an impulse from the medullar respiratory centre which sends a signal down the spinal cord
- This then goes to the phrenic and intercostal nerves
- Which innervate the diaphragm and intercostal muscles
- This causes an inspiration
- When the DRG then pauses (when it doesn’t fire), it will cause relaxation of the muscles causing a passive expiration
What are the DRG signals known as?
ramp signals
What are ramp signals
Firing of the signals from the DRG
- Their ability to be controlled and altered, that is you can increase the rate of the ramp signal (increasing lung volume more rapidly, controlling tidal volume [make the triangle taller]) and you can alter the termination point (used to control breathing frequency, [make the triangle longer])
- The combination of these two advantages means we only need 1 signal to control inspiration. Not one for tidal volume or one for frequency, the ramp signal allows us to control both with one signal
What controls the inherent respiratory rhythm of DRG?
Pre-Botzinger complex
What are the 3 areas of the VRG
- Caudal VRG
- peachy colour
- is home to expiratory neurons - Rostral VRG
- Blue area
- Mostly inspiratory neurons - Botzinger complex (not to be confused with the pre-botzinger complex)
- Pink area
- Mostly expiratory neurons
What is responsible for active inspiration and active expiration?
Ventral respiratory group (VRG)
What controls the ‘off’ switch for the DRG inspiratory ramp signal?
Pneumotaxic centre of the PONS
What prolongs the inspiratory ramp, increasing the tidal volume and decreasing breathing frequency?
Apneustic centre of the PONS
What is the function of the PONS
- Is concerned with the fine control of breathing and is known as the pontine respiratory group (PRG) which simply put, plays with the ramp signal put forward by the DRG
- Not essential for the generation of respiratory rhythm – fine control
What are the two groups that make up the PONS?
- Pneumotaxic centre
- Controls the ‘off’ switch for the DRG inspiratory ramp signal
- This will decrease tidal volume and increase breathing frequency
- ‘shortens the ramp’ - Apneustic centre
- This centre prolongs the inspiratory ramp, increasing the tidal volume and decreasing breathing frequency
- ‘The ramps get longer and higher’
What other 3 areas of the brain that the PONS acts as a relay station for?
- Cortical control (which provides you with voluntary control over breathing)
- Peripheral sensory information (temperature, odour etc.) which may affect breathing
- Visceral and cardiovascular inputs (pain, changes in blood pressure)
What provides you with voluntary control over breathing?
Cortical control
What happens when you hold your breath to the DRG and pre-botzinger complex
- When you want to hold your breath, you temporarily ignore the DRG and pre-botzinger group (you don’t turn it off) and instead act directly on the respiratory muscles motor neurons
What is odines curse?
- Now known as primary alveolar hypoventilation syndrome, this is a breathing disorder caused by a defect in the automatic respiratory control
have lost automic breathing but can breath on command easily