Week 6 Cholesterol Medications Flashcards
Atorvastatin
Lipitor
Cardiovascular
Cholesterol Lowering
Statin
Hyperlipidemia, Prevention of cardiovascular disease, familial hypercholesterolemia
myalgias, rhabdomyolysis, elevated LFTs, elevated blood glucose
No BBW, CI in pregnancy, caution in liver disease, diabetes, geriatric patients
Ezetimibe
Zetia
Cardiovascular
Cholesterol Absorption Inhibitor
Hyperlipidemia, familial hypercholesterolemia, homozygous sitosterolemia
GI (diarrhea, bloating), upper respiratory tract infection
Fibrates, bile acid sequestrants
Moderate-severe liver impairment
Ezetimibe/Simvastatin
Vytorin
Cardiovascular
Cholesterol Lowering
Cholesterol Absorption Inhibitor/Statin
Fenofibrate
Lipofen
Tricor
Cardiovascular
Cholesterol Lowering
Fibrate
hypertriglyceridemia GI (indigestion, diarrhea, constipation nausea), elevated LFTs, myopthy
Statins, cholesterol absorption inhibitors, warfarin
Caution in kidney dysfunction
Lovastatin
Mevacor
Altoprev
Cardiovascular
Cholesterol Lowering
Statin
Hyperlipidemia, Prevention of cardiovascular disease, familial hypercholesterolemia
myalgias, rhabdomyolysis, elevated LFTs, elevated blood glucose
macrolides, CCBs, warfarin, gemfibrozil
No BBW, CI in pregnancy, caution in liver disease, diabetes, geriatric patients
Niacin
RX and OTC
Niaspan Slo-Niacin
Cardiovascular
Cholesterol Lowering
Water-soluble vitamin
dyslipidemias, extreme triglyceride elevation
Flushing, edema, elevated BG, elevated uric acid, GI
bile acid seuestrants
Warning in liver disease, peptic ulcer disease, diabetes
Pravastatin
Pravachol
Cholesterol Lowering
Statin
Hyperlipidemia, Prevention of cardiovascular disease, familial
hypercholesterolemia
myalgias, rhabdomyolysis, elevated LFTs, elevated blood glucose
gemfibrozil
No BBW, CI in pregnancy, caution in liver disease, diabetes, geriatric patients
Rosuvastatin
Crestor
Cardiovascular
Cholesterol Lowering
Statin
Hyperlipidemia, Prevention of cardiovascular disease, familial hypercholesterolemia
myalgias, rhabdomyolysis, elevated LFTs, elevated blood glucose
warfarin
No BBW, CI in pregnancy, caution in liver disease, diabetes, geriatric patients
Simvastatin
Zocor
Cardiovascular
Cholesterol Lowering
Statin
Hyperlipidemia, Prevention of cardiovascular disease, familial hypercholesterolemia
myalgias, rhabdomyolysis, elevated LFTs, elevated blood glucose
gemfibrozil, CCBs, macrolides
No BBW, CI in pregnancy, caution in liver disease, diabetes, geriatric patients
Omega 3 Fatty Acids
RX and OTC
Lovaza Vascepa Cardiovascular Supplement/Cholesterol Lowering Dietary Supplement Dietary Supplement; Hypertriglyceridemia Eructaton; fishy aftertaste/burb; GI irritation Antiplatelets; Warfarin Hepatic effects; Lipid elevaton; Fish allergy; Prolonged bleeding time
Which of the following medications is a statin? A. Atorvastatin B. Fenofibrate C. Ezetimibe D. Niacin
A. Atorvastatin
Muscle pain due to a statin medication will present…
A. In one calf only
B. In both calve
B. In both calve
Could occur in only one calf, but
most likely CK will be elevated from
muscle breakdown universally, causing muscle pain in both calves. Unilateral calf pain may be a sign of overexertion
Statins should be used cautiously in which patient population? A. Pregnant females B. Cognitive decline C. Physically inactive D. Heart failure
B. Cognitive decline
Which of the following branded medications contains a cholesterol absorption inhibitor? A. Crestor® B. Tricor® C. Lipofen® D. Zetia®
D. Zetia®
Which of the following branded medications is a fibrate?
A. Lipofen®
B. Lipitor®
C. Mevacor®
D. Vytorin®
A. Lipofen®
Niacin should be avoided in which disease state?
A. High blood pressure
B. Gout
C. Kidney disease
B. Gout
Which cholesterol medication should be selected in patients with primarily elevated triglycerides? A. Fenofibrate B. Niacin C. Atorvastatin D. Ezetimibe
A. Fenofibrate
Simvastatin should not be administered with which of the following medications? A. Lisinopril B. Ezetimibe C. Fenofibrate D. Hydrochlorothiazide
C. Fenofibrate
Which supplement causes a fishy taste or smell? A. VitaminC B. VitaminD C. Ferrous Sulfate D. Omega 3 Fatty Acids
D. Omega 3 Fatty Acids
Patient counseling for statins
Patients should be educated about risk for muscle aches- stress this is usually bilateral in the calves
DO NOT use red yeast rice for cholesterol control especially while taking statins- contains lovastatin
Discuss the importance of contraception in women of child bearing age
Clinical pearls for statins
Drug interactions and side are least likely with hydrophilic- pravastatin, rosuvastatin
Patients can try out statins when experiencing muscle pain
Statins target LDL cholesterol- first line therapy in dylipidemia
Patient counseling for cholesterol absorbing inhibitors
Report any signs of vomiting, nausea, abnormal pain or change in appetite- gall stones
Take it with same time daily- consider with a meal
Patient counseling for fibrates
Take 30mins before meals
Avoid alcohol
Patient counseling for water soluble vitamins
Swollen tablets whole
Pretreat with Aspirin or ibuprofen
Flushing may be worsen by hot baths showers hot beverages and spicy foods
Clinical pearls for water soluble vitamins
ER dosing is not equal to IR dosing
Patient counseling for omega 3 fatty acids
Fishy burb can be minimized by freezing caplets
Review EPA AND DHA
Hyperlipidemia
High cholesterol
LDL
bad cholesterol
HDL
Good cholesterol
Dylipidemia
Abnormal cholesterol
Myalgia
Muscle pain
Rhabdomyolysis
Muscle breakdown
Eructation
Burp
