Week 6

Question 1

What substances of abuse can cause substance induced anxiety?

Answer 1

All substances of abuse

Question 2

Although helpful for anxiety, what drugs have abuse potential when treating anxiety?

Answer 2

Benzo’s

Question 3

What drugs can be used to treat anxiety disorders

Answer 3

SSRI’s, TCA’s, MAO-I’s, SNRI’s (Antidepressants)

Question 4

What are positive symptoms of schizophrenia?

Answer 4

Hallucinations, delusions, agitation behaviors

Question 5

What are negative symptoms of schizophrenia?

Answer 5

Anhedonia, apathy, blunted/flat affect, poverty of thought, emptiness, a motivational

Question 6

What region of the brain is responsible for mesolimbic overactivity and what type of symptoms does it produce?

Answer 6

positive symptoms. Dopamine goes from the VTA to Nucleus Accumbens and amygdala.

Question 7

What region of the brain is responsible for mesocortical underactivity and what type of symptoms does it produce?

Answer 7

Prefrontal cortex. Negative symptoms. Dopamine

Question 8

What is the mechanism of action of benzos

Answer 8

the bind to the GABA receptor and will enhance the conductance of chloride ions. This results in neurons being LESS likely to fire and thus “quiets or inhibits” the central nervous system.

Question 9

What is the mechanism of action for busbar

Answer 9

This is a partial agonist at the serotonin-1a receptor (5HT1a). It will enhance the effects of SSRI’s and can itself help with GAD.

Question 10

What is the mechanism of action for abilify

Answer 10

Aripiprazole is a partial agonist at the Dopamine-2 receptor. In a patient with schizophrenia, by being a partial agonist, it will increase frontal lobe dopamine activity (because the baseline dopamine is low = negative symptoms of schizophrenia). It will also decrease the dopamine activity in the midbrain (limbic) dopamine (because there the dopamine is very high in schizophrenia = positive symptoms)

Question 11

What neurotransmitters are impacted by PTSD?

Answer 11

Serotonin, GABA, Dopamine & Norepinephrine

Question 12

What neurotransmitters are impacted by OCD?

Answer 12

Serotonin, Dopamine,

Question 13

What neurotransmitters are impacted by Social anxiety disorder?

Answer 13

norepinephrine, serotonin, GABA

Question 14

What neurotransmitters are impacted by Panic Disorder

Answer 14

norepinephrine, serotonin, GABA

Question 15

What were the mechanism of action for typical antipsychotics?

Answer 15

Dopamine D2 receptor antagonists. They were intended to block the dopamine receptor sites.

Question 16

What are the mechanisms of action for A typical antipsychotics?

Answer 16

?

Question 17

Do A-Typical antipsychotics help positive or negative symptoms?

Answer 17

Both

Question 18

What are some common side effects with antipsychotics?

Answer 18

weight gain, movement issues, heart disease, dizziness, hypersalivation.

Question 19

Schizophrenia is not treatable - True or False

Answer 19

false

Question 20

residual symptoms and impairment often persist after treatment of schizophrenia, T or F?

Answer 20

True

Question 21

what % of patients with schizophrenia stop their medication?

Answer 21

70-100%. It is terrible.