week 5 psychotic disorders Flashcards
Types of Psychotic Disorders
- Schizophrenia
- Schizoaffective disorder
- Delusional disorder
- Brief psychotic disorder
- Substance/medication induced psychotic disorder
- Schizophreniform disorder
PSYCHOTIC SYMPTOMS
positive symptoms
-hallucinations
-delusions
-disorganized behaviour
-disorganized speech
PSYCHOTIC SYMPTOMS
negative symptoms
-affective flattening
-anhedonia
-alogia
-avoliition
-asociality
schizophrenia -neurobiology
-genes
-psychosocial adversity in childhood
-ongoing or recent psychological stress
-dopamine
-serotonin
hallucinations
Perceptual Disturbances- anything that alters the 5 senses
- Perceptual experiences that occur in the absence of actual external sensory stimuli and
may be auditory, visual, tactile, gustatory, or olfactory
-auditory is the most common
delusions
○ A false, fixed belief, based on an incorrect inference about reality, not shared by others,
inconsistent with the individual’s intelligence or cultural background and which cannot be corrected by reasoning
Persecutory/Paranoid
delusions
Think being watched, ridiculed, harmed or plotted against ● Someone spying on me..they will hurt me
magical thinking delusions
If I do ___, there will be an earthquake
grandiose delusions
exceptional powers, wealth, skill, influence or destiny
● I am prime minister, I am(/will be) famous
Somatic delusions
Think they have abnormality in body or medical problem
● My hand doesn’t belong to me,
● infested w/ parasites
Affective Flattening or blunting:
restriction or flattening in the
range and intensity of emotion, (little or no emotion shown- they understand the emotion, they cannot express it
Alogia:
Reduced fluency and productivity of thought and speech
■ reduction in quantity of words spoken
poverty of speech- difficulty getting words out
Anhedonia
inability to experience pleasure.
Avolition
withdrawal and inability to initiate and persist in goal-directed activity (may not do ADLs..ex:dressing)
■ decreased motivation
-loss of ability to do anything
Asociality
no desire to be social or to be around people
difference between amotivation and avolition
-amotivation- loss of motivation towards anything, can be social, work, etc.
-avolition is loss of motivation towards a goal oriented activity- ex. work, school
Neurotransmitter Influence on Psychotic Symptoms-
dopamine
-influences decision making –> disorganized behaviour –> disorganized thinking
-influence motivation –> amotivation- avolition
-influence arousal- asociality
-signals pleasure and reward -anhedonia
Neurotransmitter Influence on Psychotic Symptoms
-seratonin
-feeling –> affective flattening -mood
-energy level–> avolition
-social behaviour –> ascoiality -anhedonia
-sexual desires –> amotivation- anhedonia
-perception -hallucinations -delusions
-Sensorium & cognitive functions –> memory -attention
-somatic functions –> appetite -sleep
Schizophrenia: Diagnostic Criteria (DSM-5, 2013)
Diagnostic Criteria: Schizophrenia
Two or more of the following symptoms each present for a significant length of time over 1 month
-Delusions
-Hallucinations
-Disorganized speech
-Grossly disorganized or catatonic behavior
-Negative symptoms -avolition, anhedonia, affective flatting, asociality, amotivation
-Social or occupational dysfunction
- Symptoms cause clinically significant distress or impairment in social, occupational or other important areas of functioning
- Episode not attributable to physiological effects of a substance or another medical condition
- Episode not better explained by schizoaffective disorder, schizophreniform disorder, delusional disorder, or other psychotic disorder
Schizoaffective Disorder: Diagnostic Criteria (DSM-5, 2013)
Diagnostic Criteria: Schizoaffective Disorder
At least 2 symptoms of a psychotic disorder for 2 or more weeks
-Delusions
- Hallucinations
- Disorganized speech
- Grossly disorganized or catatonic behavior
- Negative symptoms-flat affect, anhedonia, avolition, amotivation, asociality
+
-A major mood episode that lasts for an uninterrupted period of time
- Mood symptoms present for the majority of the illness
- The mood disturbance is sufficiently severe to cause marked impairment in social or occupational functioning or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features
- The episode is not attributable to the physiological effects of a substance
Psychotic Disorders: Pharmacotherapeutic Interventions: Antipsychotics
-First generation or atypical antipsychotics increase dopamine in the brain to help reduce or relieve the symptoms of schizophrenia
-Second generation or atypical antipsychotics increase both dopamine and serotonin
-Antipsychotics are always offered with adjunctive non-pharmacological interventions to improve clinical outcomes
Psychotic Disorders: Pharmacological Interventions: Antipsychotics
FIRST GENERATION
“TYPICAL”
Haloperidol (Haldol) - commonly used in the ED but should not be repeated doses
Thorazine (Chlorpromazine)
Fluphenazine (Moditen, Modecate)
Trilafon (Perphenazine) Loxapine (Loxitane)
Thioridazine (Mellaril)
Psychotic Disorders: Pharmacological Interventions: Antipsychotics
SECOND GENERATION “ATYPICAL”
Olanzapine (Zyprexa) - causes the MOST weight gain, also the most common drug and can be used orally or a long-acting injection
Quetiapine (Seroquel) Ziprasidone (Zeldox) Paliperadone (Invega) Aripripazolole (Abilify) Risperidone (Risperdal) - oral and long-acting injection
Clozapine (Clozaril)-lowers WBC count = risk of infection so constantly needs blood work, stop taking if reaction occurs but there are less side effects and a better response
Possible Side Effects of Antipsychotic Medications
Anticcholinergic effects
Dry mouth (can use a life saver or butter scotch candy to counter this), constipation, urinary retention, bowel obstruction, dilated pupils, blurred vision, increased heart rate, decreased sweating