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Block 3 > Week 5 Pharm - DMARDs > Flashcards

Week 5 Pharm - DMARDs Flashcards

1
Q

Describe the function of tacrolimus

A

Tacrolimus inhibits calcineurin and inhibits production of cytokines

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2
Q

Describe the function of sirolimus and everolimus

A

They inhibit mTOR and inhibit T cell response to cytokines

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3
Q

What are the side effects of tacrolimus?

A

Nephrotoxicity, neurotoxicity, hypertension

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4
Q

What are the side effects of sirolimus and everolimus?

A

Hepatotoxicity (liver), myelosuppression (thrombocytopenia)

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5
Q

Describe the function of leflunomide

A

Inhibits pyrimidine synthesis; very teratogenic

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6
Q

Describe the function of mycophenolate mofetil

A

Inhibits IMPDH (de novo purine synthesis)

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7
Q

What are the side effects of TNF-alpha inhibitors?

A

Reactivation TB

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8
Q

What is the preferred combination of medication for maintenance immunosuppression?

A

antiproliferative agent, corticosteroid, calcineurin inhibitor

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