Week 5 part 2 Flashcards
What was opioid receptor discovery in 1970 for?
Targets for morphine and heroin
What did targets for morphine and heroin lead to?
Discovery of neuropeptide (enkephalins and endorphins) as endogenous ligands for these receptors
What did discovery of cannabinoid receptors in the late 1980’s suggest
endogenous ligands for these receptors may be produced in the brain
What may endogenous cannabinoid receptor ligands be?
neuropeptides
What were neuropeptides shown to be?
Ligand for opioid receptors
Where was the first endogenous cannabinoid receptor isolated from?
Brain
Identified as a derivative of fatty acid arachnoid acid
What was endogenous cannabinoid receptor ligand purified from?
brain extract as a compound that binds to cannabinoid receptors
What is the first endogenous cannabinoid receptor ligand named chemically
- arachidonoylethanolamide
2. Known as anandamide
in 1995, what was the secind endogenous cannabinoid receptor ligand identified as?
2-arachidonoylglycerol
Named as arachidonoylglycerol
Why is anandamide and 2AG structurally similar?
They are derivatives of arachnoid acid
What do anandamide and 2AG act as?
endogenous ligands for cannabinoid receptors CB1 and CB2
What can anandamide and 2AG be traced back to?
common ancestor of caudate which will take u back ½ a billion years
What is the evolutionary origin of the cannabis plant?
50 million years
What is cannabinoid receptors in the brain?
At least 10 times older than THC is
Where is 2AG synthesised ?
In the brain via a specific pathway