Week 5: Microbiology P.II Flashcards

1
Q

first line of defense that we are born with

A

innate system

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2
Q

immune system that develops throughout life, immunological memory

A

adaptive system

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3
Q

nonspecific immune system

A

innate system

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4
Q

antigen-specific system

A

adaptive system

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5
Q

function of the immune system

A
  • defends host

- recognizes invaders and responds by sending cells to site and producing biochemical substances

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6
Q

HIV/AIDS destroy

A

CD4 cells

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7
Q

WBC that phagocytize, short-lived, 1st line of defense, hallmark of acute inflammation

A

PMNs (neutrophils)

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8
Q

leukocyte that is a large phagocyte, slower at responding, long-lived, in chronic inflammation, t-cells

A

monocytes/macrophages

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9
Q

two types of lymphocytes

A

b-lymphocytes

t-lymphocytes

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10
Q

b-lymphocyte function

A

make antibodies

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11
Q

t-lymphocyte function

A

intensifies response of others, produce cytokines (interleukins)

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12
Q

two types of b-lymphocytes

A

plasma B-cells, memory B-cells

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13
Q

classes of immunoglobulins

A

IgM, IgD, IgG, IgA, IgE

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14
Q

antibodies are _____ and have these 3 functions

A

Y-shaped

  1. neutralize bacteria/toxins
  2. coat bacteria
  3. activate complement system
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15
Q

complement system

A
  1. destroy pathogens via membrane attack
  2. opsonization of pathogens
  3. recruitment of phagocytes
  4. immune clearance
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16
Q

timeline of events in inflammation

A

inflammatory response, acute inflammation, chronic inflammation, exaggerate host inflammatory response

17
Q

even healthy gingival CT contains at least ___________

A

some inflammatory cells (neutrophils)

18
Q

cytokines are ____ that are ____ or ____

A

proteins, pro-inflammatory/anti-inflammatory

19
Q

inflammatory mediators released by leukocytes

A

IL-1, IL-6, IL-8, TNF-alpha, PGE-2, MMP enzymes, prostaglandins

20
Q

when does acute inflammation turn to chronic inflammation?

A

2 weeks

21
Q

functions of IL-1

A
  • stimulates osteoclast activity

- induces breakdown of collagen matrix

22
Q

functions of IL-6

A
  • stimulates osteoclast activity

- inhibit bone formation

23
Q

functions of IL-8

A
  • stimulates osteoclast activity

- stimulates CT destruction

24
Q

PGE initiates _____

A

most of alveolar bone destruction in periodontitis

25
Q

main sources of PGE

A

macrophages, fibroblasts

26
Q

_____ and ____ are major sources in periodontitis

A

PMNs, gingival fibroblasts

27
Q

function of MMP enzyme in health

A

facilitate turnover

28
Q

function of MMP enzymes in disease

A

overproduction results in collagen/connective tissue

breakdown

29
Q

pro-inflammatory mediators

A
IL-1B
TNFa
IFN
PGE2
MMPs
30
Q

anti-inflammatory mediators

A

IL1ra, IL-10, TGFb, TMIPs