Week 5 - Exercise is Medicine Flashcards
we are in a Global epidemic of Inactivity
responsible for cancer and heart disease
5 leading causes of death:
1) High BP
2) Tobacco use
3) High blood glucose
4) Physical inactivity
5) overweight/obesity
Physical activity is FOURTH leading cause of premature death
plan calls for 10% reduction by physical inactivity by 2025
Contributors to Overall Health Status
Environment contains social supports, employment, education, etc.
50% Health Behaviours (Exercise, Smoking, Diet)
20% Genetics
20% Environment
10% Access to Medical Care
Physical Activity
“in view of the prevalence, global reach and health effect of physical inactivity, the issue should be appropriately described as pandemic, with far-reaching health, economic, environmental, and social consequences” - the lancet
*This is the problem*
Exercise is Medicine Canada
Originally from US
Movement to encourage a healthy lifestyle among Canadians
Programs are based on abundant evidence the physical activity and exercise reduce the risk of chronic disease and the belief that:
Exercise is Medicine Belief
- most canadians can find simple ways to incorporate physical activity and exercise into their daily routines;
- more should be done to address physical activity and exercise in the healthcare setting; physical activity and exercise should be incorporated as a key health indicator and standard of medical care as a ‘vital sign’
- certified exercise professionals serve as important resources for Canadians and their healthcare providers
EIM Exercise Prescription & Referral Tool
- Reduce sedentary behaviour and physical inactivity recommendations
- Recommending how much exercise
- More likely to comply/adopt behaviour change if doctor tells it
- If exercise was a drug, it would be the most effective
Exercise Prescription and Referral Sheet
- reduce sedentary behaviour options
- physical activity recommendations
exercise is effective. if exercise was a drug, it would be one of the most effective and safe ways to prevent and treat many chronic diseases such as heart disease, hypertension, diabetes, osteoporosis, anxiety disorders and depression
Secondary Prevention Outcomes
- Delayed birth
- Lower disease recurrence
- Lower disease severity
- Fewer hospitalizations (‘events’)
- Fewer procedures
- Fewer medications/lower doses
- Higher HR-QoL
- Improved biomarkers/clinical risk factors
- Faster return to work/life
- System cost-savings
Best Way to increase PA
start slow and low
- Do it more often, eat better, and do more
Exercises Immunity & COVID-19
Exercise instantaneously mobilizes immune cells
Exercise & Immunity
- Having higher age and sex-adjusted scored for cardiorespiratory fitness (CRF) and performing regular exercise of moderate- to vigorous-intensity exercise (within ACSM guidelines)
- improves immune responses to vaccination
- lowers chronic low-grade inflammation
- improves immune markers in several disease states including cancer, HIV, cardiovascular disease, diabetes, cognitive impairment and obesity.
Exercise, Immunity, & COVID-19
- PA has positive effects on normal functioning of immune system, especially for older adults (>65years).
- Contracting skeletal muscle releases cytokines that promote T-cell and NK-cell maintenance and trafficking.
— Can help sore need by having more resources readily available (not having to fight other shit)
Beneficial effects of exercise likely offer protection against SARS CoV2 and may help boost immune responses to a future vaccine, protecting vulnerable populations from COVID-19.
Exercise training and CRF
- Exercise training and CRF: promote maintenance of the peripheral T-cell pool—
- lower infection risk
Based on what we know…
- 30-60 minutes of moderate-intensity exercise 3-5 days per week can help boost/ maintain immune function
- Even a 30-minute brisk walk provides immediate immune benefits that can last for several hours afterwards.
- Up to 72 hour layover
-
Caution: Unaccustomed high volume, high-intensity exercise training that far exceed recommended guidelines may stress the immune system.
– Extreme either way negatively affects you
Comparative Effectiveness of Exercise and Drug Interventions on Mortality Outcomes: Meta-epidemiological Study
- Meta-analysis of 16 studies (4 exercise, 12 drug) that compared the effectiveness of exercise interventions vs. drug therapy
- Exercise and drug interventions did NOT differ in terms of mortality benefits or in:
– secondary prevention of coronary heart disease
– rehabilitation after stroke,
– treatment of heart failure, and
– prevention of diabetes
– In some cases, like stroke rehabilitation, exercise intervention was more effective!
Meta-epidemiological Study CONCLUSIONS
- Exercise and many drugs are similar in terms of their benefits
- Exercise interventions SHOULD be considered as a viable alternative to, or alongside, drug therapy
- PHYSICAL ACTIVITY needs to become the prescribed “PILL” of the future!
Regular Exercise on Low Back Pain Reduction
- Early data suggests 40% reduction in self-reported pain aerobic exercise;
- but little evidence
Cancer: Increases in HR-QoL
Physical Activity and Depression & Anxiety
- 1 in 5 adults will experience anxiety or depression in their life
- Significantly higher for university students — we also have better statistics for this population
- Unless you report mental health as primary reason for visit, will not be reported
– Anxiety: reduces symptoms as much as drugs
— Stubbs et al., 2017
— An examination of the anxiolytic effects of exercise for people with anxiety and stress-related disorders: A meta-analysis
— Fewer anxiety symptoms for exercise group
— Even walking can alleviate symptoms
Reduction in Depressive Symptoms
- Schuch et al., 2016 Meta-analysis
- _Aerobic training MOST effective_ But all types beneficial
- Recommend first line monotherapy for mild to moderate depression
- Can be used alongside primary therapy for severe (drugs or CBT) — Combination for severe
- Need to monitor closer
- May take a few weeks — 4-6 weeks to start seeing effects
- Just as effective as drugs
Exercise for Anxiety/Depression: How does it work?
1) physiological mechanisms
2) psychological mechanisms
3) inflammatory mechanisms
Physiological Mechanisms
ie. action of endorphins, elevation of body temp, function of mitochondria and neuroplasticity, and changes in serotonin
Psychological Mechanisms
ie. distraction or mental time out, master and self-efficacy
Inflammatory Mechanisms
ie. evidence of a link between the immune system and the nervous system
Physical Activity & Depression
Article: Bushman (2019), American College of Sports Medicine Journal
- Q: Is physical activity of any benefit in preventing or treating depression?
1) >20% of adults 18-49yo experience major depressive episode (USA, ‘17)
2) Treatment is often delayed/absent (e.g., medication, CBT)
3) Aerobic exercise (and possibly resistance exercise) reduces symptoms as much as meds/CBT
4) In a few weeks, ≥30min x ≥3 days/week reduces odds of experiencing depression by 48% (and dose-response relationship)
Physical Activity & Type 2 Diabetes
- Patho-physiology — the PROBLEM for health care
– More individuals are entering the health care system who are sedentary, obese, becoming frail and requiring chronic disease prevention and management care. - Pre-diabetes — don’t have it yet but on your way
– Lifestyle adjustments very important here - Body does not like it when blood glucose rises
– Tries desperately to get it out
Diabetes: microvascular complications
- Leading cause of blindness, end-stage renal disease, non-traumatic amputations
- Cardiovascular disease leading cause of death for people with diabetes
– 2-4X more likely - 1 in 4 die with diabetes
UK Prospective Diabetes Study
- Reduce blood sugar, A1C levels reduce micro and macro complications
- Each 1 point (1%) reduction, very huge benefits
Robert E. Sallis, MD, FACSM - EIM Advisory Board Chair
“What if there was one prescription that could prevent and treat dozens of diseases, such as diabetes, hypertension and obesity? Would you prescribe it to your patients? Certainly!”
Step 1: Lifestyle Interventions
- 0.5 reduction with aerobic alone; resistance training alone
- Benefits additive combined = 1.0%!!!
- Not common knowledge
Immediate Benefits — lower your blood glucose within 1 hour
- improve your mood, sleep patterns and energy level
- increase the effectiveness of the insulin your body makes or the insulin your doctor prescribes for you
Long-term Benefits — improve your blood glucose control
- reduce your body fat
- help keep your pancreas, kidneys, eyes and nerve healthy
- reduce the risk of heart attack, stroke, and death
Reading Highlights
- PA reduces A1C and serious T2D complications
- Both aerobic and resistance type exercise; Yoga and Aquafit class work, too!
- Limiting sitting time is important (stand every 30mins)
- Make it stick! E.g., count steps
- Exercise prescription examples
Physical Activity & Heart Disease
- Perfusion (blood flow by mass) is not equal to blood flow
- Ischemic = limitation of blood flow to heart
– Plaque buildup
– Lack of exercise and poor diet
Strict Bed Rest Policy
NOT GOOD
Cardiac Rehabilitation
“the enhancement and maintenance of cardiovascular health through individualized programs designed to optimize physical, psychological, social, vocational, and emotional status
“the facilitation and delivery of secondary prevention through risk factor identification and modification in an effort to prevent disease progression and recurrence of cardiac events”
Cardiac Rehabilitation
up to 45-60 min/day
- 2-3 RT
- 2-3 flexibility
Quit smoking, eat healthier, add a little exercise; more likely to take medication
Exercising a little bit, more likely to adopt healthier behaviours
PERIPHERAL benefits
FASTER than central benefits
- improve skeletal muscle
CENTRAL benefits
take longer, need more commitment
- greater ejection fraction — takes 6 MONTHS