Week 5-8 Flashcards

1
Q

Name the 7 threats to Internal Validity

A
Bias from the assessor
Recall bias
Placebo effect
Hawthorne effect
Natural recovery/maturation
Regression to the mean
Process of treatment
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2
Q

How do researchers manage threats to validity?

A

Control group

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3
Q

Define: Blinding

A

means not knowing who is receiving the true intervention, and who is receiving the control

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4
Q

Which level of evidence reduces the potential for bias, increases internal validity and has better strength of evidence

A

The evidence further up the hierarchy of evidence

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5
Q

What type of evidence is the lowest level of evidence?

A

Expert Opinion

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6
Q

If the Exposure is ‘known’ and the outcome is ‘unknown’ what type of evidence is this?

A

Cohort

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7
Q

If the Exposure is ‘unknown’ and the Outcome is ‘Known’ what type of evidence is this?

A

Case control

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8
Q

Name the Levels of Evidence in order of best evidence to lowest level of evidence

A
  • Clinical guidelines/summaries
  • Systematic reviews
  • RCT’s
  • Non-RCT’s
  • Cohort studies
  • Case control studies
  • Case series/time series
  • Case reports
  • Expert opinions
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9
Q

Explain: Case series

A
  • same as a case study but more than one person

- group of people usually measured before and after intervention but has no control group

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10
Q

Explain: Case-control study

A
  • used to evaluate relationships, treatments and cause of disease
  • Is retrospective (looks back in time)
  • Compares history & exposure of people who have a condition with those that don’t
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11
Q

Explain: Cohort study

A
  • Is prospective (looks forward in time)
  • compares the progress of people who are exposed and/or receive a particular treatment and a control group
  • epidemiological research design
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12
Q

Explain: RCT

A
  • most rigorous design of health research to determine whether a cause-effect relationship exists
  • not always ethical/feasible (so cohort or case control might be necessary)
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13
Q

Explain: Systematic Review

A
  • combines more than one primary study for any research question
  • bias is minimised here
  • critically appraises studies
  • combines studies statistically (if possible) which is called a meta-analysis
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14
Q

Explain: Summaries or Guidelines

A
  • asks clinical questions
  • summarises evidence for a topic
  • provides evidence-based guidelines for practice
  • are reviews of systematic reviews
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15
Q

What is an intervention?

A

Anything that can have a cause and effect but usually means a treatment

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16
Q

Define: Ethics

A

‘how we ought to live’

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17
Q

What are the Universal Principles of Ethics

A

Autonomy
Non-maleficence
Beneficence
Justice

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18
Q

Name the 2 types of Ethical Theory

A

Deontology

Teleology

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19
Q

Define: Deontology

A

Intrinsic ethical absolutes

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20
Q

Define: Teleology

A

Relative consequentialism

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21
Q

Give an example: Deontology

A

Taking a life is always wrong

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22
Q

Give an example: Teleology

A

taking a life might be right or wrong depending on the circumstances

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23
Q

What are the 3 main applications of Ethical Theory

A

Altruism- best consequences for others

Egoism- best consequences for an individual

Utilitarianism- best consequences for the greatest number

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24
Q

When ethical issues present in health it is refer to as…

A

Bioethics

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25
Q

What are the principles included in the Nuremberg Code

A
  • voluntary informed consent
  • absence of coercion
  • properly formulated experimentation
  • beneficence towards experiment participants
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26
Q

When was the International Ethical Guidelines for Biomedical Research Involving Human Subjects developed?

A

1982

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27
Q

Who developed the ‘International Ethical Guidelines for Biomedical Research Involving Human Subjects’

A

CIOMS- Council for International Organisations of Medical Science
and WHO

28
Q

In Australia, when did ethics guidelines development begin?

A

1960’s

29
Q

Define: HREC

A

Human Research Ethics Committee

30
Q

Define: Protocol

A

The research plan- how the research will be conducted in detail

31
Q

Define: Representative Sample

A

means that all those who should be represented, are reflected in the sample

32
Q

Define: Parameter

A

is the measure or descriptor that applies to the Population or target group

33
Q

Define: Statistic

A

is a measure or descriptor that applies to the Sample group

34
Q

Define: Random Sampling

A

is when all members of the population have an equal chance of selection

35
Q

Define: Reliability

A

is the reproducibility of the results of a procedure or tool

36
Q

Define: Variable

A

the item of interest or thing we are measuring

37
Q

Define: Measurement

A

is the process of quantifying this variable (item being measured)

38
Q

What are the 3 Error Types in measurement

A

Sources of error
Types of error
Types of reliability

39
Q

Give an example: Sources of error

A
  • Equipment
  • Patient/participant
  • Measurer/researcher
40
Q

Name the 2 Types of Measurement Error

A
  • Systematic errors

- Random errors

41
Q

Give an example: Types of reliability errors

A
  • test-retest reliability
  • Intra-rater reliability
  • Inter-rater reliability
42
Q

Define: Test-retest reliability

A

to establish that a measurement instrument is capable of obtaining the same results with consistency

43
Q

Define: Intra-rater reliability

A

the stability of data recorded by one individual across two or more trials

44
Q

Define: Inter-rater reliability

A

the stability of data recorded by more than one individual in one trial

45
Q

Define: Correlation

A

measures the strength of association between two variables

Is a common measure of association

46
Q

Name the 3 types of validity

A

Measurement validity
Internal Validity
External Validity

47
Q

Define: Measurement validity

A

the degree to which a test actually measures what it is meant to measure

48
Q

(Measurement Validity)

Name the 3 reasons we measure things

A
  • Discriminate between individuals
  • Evaluate change in the magnitude or quality
  • Predict make useful and accurate predictions or diagnoses about a patient/client/group
49
Q

Define: Validation

A

the degree of confidence we have in the inferences (results) we draw from test measurements

50
Q

(Measurement Validity)

Name the 4 ways you determine the type of validity

A
  • Face validity
  • Content validity
  • Construct validity
  • Criterion validty
51
Q

(Measurement Validity)

Define: Face validity

A

People think that it measures what it is supposed to measure
- lowest form of validity

(a subjective assessment based on personal opinions of people giving or taking the measurement)

52
Q

(Measurement Validity)

Define: Content validity

A

the ability of an instrument to represent all content areas of importance in a test
- usually assessed by a panel of experts

53
Q

(Measurement Validity)

Define: Construct validity

A

The test correlate with other tests that measure the same thing

(Does the measurement correlate well with other measures of the same thing and not correlate with measures of other things)

54
Q

(Measurement Validity)

Define: Criterion validity

A

Definition: the measurement can be used as a substitute measure for an established, or ‘gold standard’ measure of the same thing

Easier Definition: is when we measure using our scale against a “gold standard” scale (this is a proven scale for measuring a specific condition)

55
Q

Describe the difference between the 4 types of validity

A

Face, Construct and Content validity: determined by logical argument

Criterion validity: determined by direct testing

56
Q

Explain Reliability and Validity

A
  • A measure can be reliable but not valid

- A measure cannot be valid if it is not reliable

57
Q

What types of research uses Measurement Validity

A

Aetiology studies
Intervention studies
Prognosis studies
Diagnostic test studies

58
Q

Define: Internal Validity

A

measures how much we can trust that research conclusions are correct and true

59
Q

Define: External validity

A

is the extent to which the results of research can be generalised to other samples or situations (generalisability)

60
Q

What does it mean when there is strong internal validity?

A

we can trust the conclusions are true

61
Q

Threats to Internal Validity

Explain: Placebo effect

A

is the improvement due to only experiencing an intervention or event, whether real or not

62
Q

Threats to Internal Validity

Explain: Hawthorne effect

A

an improvement due to participants being studied, not the intervention

63
Q

Threats to Internal Validity

Explain: Natural Maturation/Recovery

A

the condition improves irrespective of the treatment

64
Q

Threats to Internal Validity

Explain: Regression to the mean

A

patients with episodic disease present for intervention when condition is severe, but from here fluctuations are likely to be less severe

65
Q

Threats to Internal Validity

Explain: Process of treatment

A
  • politeness and positivity

- psychological effects between healer and patient