Week 5-8 Flashcards
Name the 7 threats to Internal Validity
Bias from the assessor Recall bias Placebo effect Hawthorne effect Natural recovery/maturation Regression to the mean Process of treatment
How do researchers manage threats to validity?
Control group
Define: Blinding
means not knowing who is receiving the true intervention, and who is receiving the control
Which level of evidence reduces the potential for bias, increases internal validity and has better strength of evidence
The evidence further up the hierarchy of evidence
What type of evidence is the lowest level of evidence?
Expert Opinion
If the Exposure is ‘known’ and the outcome is ‘unknown’ what type of evidence is this?
Cohort
If the Exposure is ‘unknown’ and the Outcome is ‘Known’ what type of evidence is this?
Case control
Name the Levels of Evidence in order of best evidence to lowest level of evidence
- Clinical guidelines/summaries
- Systematic reviews
- RCT’s
- Non-RCT’s
- Cohort studies
- Case control studies
- Case series/time series
- Case reports
- Expert opinions
Explain: Case series
- same as a case study but more than one person
- group of people usually measured before and after intervention but has no control group
Explain: Case-control study
- used to evaluate relationships, treatments and cause of disease
- Is retrospective (looks back in time)
- Compares history & exposure of people who have a condition with those that don’t
Explain: Cohort study
- Is prospective (looks forward in time)
- compares the progress of people who are exposed and/or receive a particular treatment and a control group
- epidemiological research design
Explain: RCT
- most rigorous design of health research to determine whether a cause-effect relationship exists
- not always ethical/feasible (so cohort or case control might be necessary)
Explain: Systematic Review
- combines more than one primary study for any research question
- bias is minimised here
- critically appraises studies
- combines studies statistically (if possible) which is called a meta-analysis
Explain: Summaries or Guidelines
- asks clinical questions
- summarises evidence for a topic
- provides evidence-based guidelines for practice
- are reviews of systematic reviews
What is an intervention?
Anything that can have a cause and effect but usually means a treatment
Define: Ethics
‘how we ought to live’
What are the Universal Principles of Ethics
Autonomy
Non-maleficence
Beneficence
Justice
Name the 2 types of Ethical Theory
Deontology
Teleology
Define: Deontology
Intrinsic ethical absolutes
Define: Teleology
Relative consequentialism
Give an example: Deontology
Taking a life is always wrong
Give an example: Teleology
taking a life might be right or wrong depending on the circumstances
What are the 3 main applications of Ethical Theory
Altruism- best consequences for others
Egoism- best consequences for an individual
Utilitarianism- best consequences for the greatest number
When ethical issues present in health it is refer to as…
Bioethics
What are the principles included in the Nuremberg Code
- voluntary informed consent
- absence of coercion
- properly formulated experimentation
- beneficence towards experiment participants
When was the International Ethical Guidelines for Biomedical Research Involving Human Subjects developed?
1982