Week 4 Terms

Question 1

What are some Properties of LTP?

Answer 1

1) Input Specific
2) Cooperativity
3) Long Lasting
4) Associativity
5) It is reversible

Question 2

What are the 2 Main Receptors for Glutamate?

Answer 2

1) AMPA

2) NMDA

Question 3

What are the 3 Types of Synapses?

Answer 3

1) Axiodendritic/ Axiospino synapses - axon synapses on dendrite or dendritic spine. These account for most synapses in the brain and can be excitatory, inhibitory, or neuromodulatory
2) Axosomatic - axon synapses on the cell body and is typically inhibitory or neuromodulatory
3) Axoaxonic - axon synapes to axon

Question 4

What are Purkinje Cells? What neurotransmitter do they use & what are their 2 types of spines?

Answer 4

• an inhibitory neuron in the cerebellum
• uses GABA as their neurotransmitter
• Spines: 1) parallel fibre, 2) climbing

Question 5

What are th 3 Models of Spinogenesis?

Answer 5

1) Sotelo Model – spine formation is intrinsic and independent of the presynaptic terminal
2) Miller/ Peters – predicts sequential growth of spines from dendritic shafts, triggered by axon terminal
3) Vaughn’s (Filopodial) – Dendritic filopodia establish synaptic contacts, then reel in axon terminals toward dendritic shaft where terminal produces a spine