Week 4: Pathology of the testes

Question 1

elevated markers in testicular tumros

Answer 1

• AFP elevated in yolk sac tumor

- hCG in choriocarcinoma

Question 2

Germ cell tumors

Answer 2

Seminomatous
1. seminoma (50%): can be large mass, tunica albuginea intact, white, tan, usually no necrosis/hemorrhage. Sheets of uniform cells separated by fibrous tissue. lymphocytes seen
Non seminomatous
2. embryonic carcinoma: invades tunica albuginea early. Cut surface has necrosis/hemorrhage
3. yolk sac tumor: common in children under 3yo. Microcytic. Schiller duval bodies. (like a target)
4. choriocarcinoma: hemorrhage, necrosis. See syncytiotrophoblast and cytotrophoblast
5. teratoma: mature teratomas second most common testicular tumor in young children.

Question 3

Non germ cell tumors

Answer 3

1. Leydig cell tumor
   - crystalloids of Reinke
2. stroll cell tumor
   - rare