Week 4- inflammation and Repair

Question 1

Hyperaemia

Answer 1

Active increase in blood flow to the area (because it’s part of repair, our body’s response to injury.)

Question 2

Oedema (exudate vs transudate)

Answer 2

Oedema: fluid in the interstitial tissue. Increased fluid in the interstitial spaces (so fluid is coming out of the vessel and sitting between the cells and its swelling)

Exudate: if acute inflammatory fluid it is an exudate, a protein rich oedema. Inflammatory extravascular fluid with high protein concentration. High protein oedematous fluid caused by increased hydrostatic pressure from hyperaemia & increased vascular permeability

Transudate: low protein oedema. Extravascular fluid with low protein concentration.

Question 3

Effusion

Answer 3

Fluid in a body cavity

Question 4

Resolution

Answer 4

• Healing without scarring, restoration of structure & function.
• Possible following acute inflammation
• Depends on: Tissue type, Extent of the injury, Presence of factors that can impair repair (infection, nutrition, etc).

-Some tissues will never undergo resolution

Question 5

Ulcer and Abscess

Answer 5

Area of necrosis- on a lesion or ‘sore’ on a body surface like the skin or mucous membranes

Question 6

Organisation

Answer 6

Organization/scarring/fibrosis
* Healing by scarring/fibrosis.
* Possible following acute inflammation
– Depends upon…
* (Inevitable following chronic inflammation)
* Prior to maturation scar tissue is composed of granulation tissue
* Granulation tissue:
– Macrophages
– Fibroblasts/Myofibroblasts
– Angiogenesis
* Mature scar is made of collagen protein