Week 4 - Depression, Anxiety, OCD, PTSD, bipolar Flashcards
What is the diagnostic criteria for major depressive disorder?
Must be experiencing 5 or more symptoms during a 2-week period and at least one of the symptoms should be depressed mood or loss of interest/pleasure
Acronym = D - SIGECAPS
Depressed mood
Sleep - insomnia or hypersomnia (really tired during day)
Interest - loss of interest or pleasure
Guilt - inappropriate guilt or feeling worthless
Energy - fatigue
Concentration - decreased concentration
Appetite - can eat a lot or very little → weight gain or loss
Psychomotor retardation- slow movements or thinking
Suicidal ideation - thoughts of suicide
Additional required criteria (must have all 4, plus the 5 or more symptoms above)
* Symptoms cause clinically significant distress or impairment in social, occupational or other important areas of functioning
* Episode not attributable to physiological effects of a substance or another medical condition
* Episode not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder, or other psychotic disorder
* No history of manic or hypomanic episode
o Manic = abnormally elevated extreme changes in mood emotions, energy levels
o Hypomania = same thing but less severe form
Risk Factors of Depression:
- Prior episodes, family history, lack of social support, stressful life events
- Current substance use, medical comorbidity, economic difficulties
What is the action of antidepressants?
Increases activity of neurotransmitters in brain which lessens symptoms of depression. The neurotransmitters are dopamine, NE, and serotonin.
- Work best when combined with psychotherapy, social support, and self care
What are the functions of dopamine?
o Influences decision making
o Influences motivation
o Influences arousal
o Signals pleasure and reward
MDAP
What are the functions of NE?
o Influences alertness
o Influences motor function
o Regulates blood pressure
o Regulates HR
What is the function of serotonin?
o Regulates mood
o Appetite
o Sleep
o Social behavior
o Sexual desire
SMABS
What are the side effects of SSRIs?
HADSWISS
Headaches
Anxiety
Dry mouth
Stomach upset – N/V, diarrhea
Weight gain
Insomnia
Sedation
Sexual desire - decreased
Name the SSRIs.
- Sertraline (Zoloft)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Citalopram (Celexa)
-ine and -pram
What side effect can SNRIs have on BP?
Increase
SNRI examples:
SNRI (serotonin and norepinephrine reuptake inhibitors)
* Effexor (Venlafaxine)
* Cymbalta (duloxetine)
* Desvenlafaxine (Pristiq)
* Levomilnacipran (Fetzima)
Side Effects: Nausea, drowsiness, dizziness, nervousness, fatigue, loss of appetite, decrease in sexual desire and response, increase in blood pressure
NON-SELECTIVE CYCLICS / TCAs
- Amoxapine
- Amitriptyline (Elavin)
- Imipramine (Tofranil)
Side Effects: Dry mouth, tremors, constipation, sedation, blurred vision, difficulty urinating, weight gain, dizziness,
MAOI is in what class of medications?
Antidepressants
- Isocarboxazid (Marplan)
- Phenelzine (Nardil)
- Tranylcypromine (Parnate)
- Selegiline (Emsam)
Side Effects: Orthostatic hypotension, insomnia, swelling, weight gain
norepinephrine–dopamine reuptake inhibitor (NDRI) is in what class of medications?
Anti-depressants
NDRI
* Buproprion (Wellbutrin, Zyban)
* Mirtazapine (Remeron)
* Trazodone
* Nefazodone
Side Effects: Jitteriness, insomnia
Noradrenergic and specific serotonergic antidepressants (NaSSAs) are what class of meds?
Antidepressants
NaSSA
* Mirtazapine (Remeron)
Side Effects: Drowsiness, weight gain
Explain type 1 bipolar disorder.
Manic episode with increased energy or activity, abnormally elevated mood
Explain type 2 bipolar disorder
Hypomania and depressive episodes
What is mania?
Period of abnormally elevated mood and increased energy or activity
What is the diagnostic criteria for bipolar 1 disorder?
Diagnostic Criteria: Bipolar I
- Distinct period of abnormally and persistently elevated, expansive or irritable mood and abnormally and persistently increased goal-directed activity or energy, lasting at least 1 week and present most of the day, nearly every day
- 3 or more of the following symptoms present during the mania period: (DIGFAST)
Distractibility – gets distracted easily
Impulsivity – does thing without thinking of consequences
Grandiosity – inflated self-esteem
Flight of ideas – lots of thoughts running through mind
Activity - increase
Sleep – decreased need or deficit
Talkativeness – very talkative
Diagnostic Criteria: Bipolar I (additional required criteria)
* The mood disturbance is sufficiently severe to cause marked impairment in social or occupational functioning or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features
* The episode is not attributable to the physiological effects of a substance
What is the diagnostic criteria for bipolar 2 disorder?
- Criteria have been met for at least one hypomanic episode and at least one major depressive episode
–> Hypomanic episode is same as first two bipolar 1 criteria but lasting at least 4 DAYS instead of 1 week and LESS SEVERE - There has never been a manic episode
- The occurrence of the hypomanic episode(s) and major depressive episode(s) is not better explained by schizoaffective disorder, schizophrenia, schizophreniform disorder, delusional disorder or other specified or unspecified schizophrenia spectrum and other psychotic disorder
- The symptoms of depression or the unpredictability caused by frequent alternation between periods of depression and hypomanic cause clinically significant distress or impairment in social, occupational or other important areas of functioning
What class of medications are used to treat bipolar disorder?
Mood stabilizers
What is the most widely used mood stabilizer and gold standard for bipolar disorder?
Lithium - Increases NE uptake and serotonin receptor sensitivity
What are the common side effects of lithium?
TWUNT
Thirst
Weight gain
Urination
Nausea
Trembling of hands
and metallic taste
* Less common side effects can include tiredness, vomiting and diarrhea, blurred vision, impaired memory, difficulty concentrating, skin changes, slight muscle weakness, thyroid and kidney function changes
What is the relationship between lithium and sodium and fluid?
Lithium and sodium levels in body have inverse relationship
o High levels of sodium in body lower lithium levels less effect
o Low levels of sodium in body high levels of lithium and can increase side effects (danger)
Fluid applies too:
* If fluid loss from dehydration or hot climate or strenuous exercise lithium levels rising sharply
o Must assess electrolytes before lithium administration
What type of medication is DIVALPROEX/VALPROIC ACID/VALPROATE?
Mood stabilizer - anticonvulsant
What are the most common side effects of DIVALPROEX/VALPROIC ACID/VALPROATE?
Dizzy, drowsy, blurred vision, nausea
DDNB
What class of medications is carbamazepine?
Mood stabilizers - anticonvulsant
What are the common side effects of carbamazepine?
CARBA
- Confusion – dizziness, drowsiness
- Ataxia – lack of muscle coordination, tremors
- Rashes
- Blurred vision
- Anemia
- Common side effects include dizziness, drowsiness, blurred vision, confusion, muscle tremor, nausea, vomiting or mild cramps, increased sensitivity to sun, skin sensitivity and rashes and poor coordination
What is a rare and dangerous side effect of carbamazepine?
- A rare but dangerous side effect is reduced blood cell counts, soreness of the mouth, gums or throat, mouth ulcers or sores and fever or flu-like symptoms can be a side of this effect
What class of medications is lamotrigine?
Mood stabilizer - anticonvulsant