Week 3 (Test 1) Flashcards
Anemia by Etiology
1) BLOOD LOSS
- Acute
- Chronic
2) DECREASED PRODUCTION
- B12, Folic Acid, Fe Deficiency!!!!
- Infiltration of marrow by NEOPLASIA!!!!
- APLASTIC ANEMIA
3) INCREASED DESTRUCTION
- Hemolytic Anemia!!!!!
Lab Value Classifiation
1) MICROCYTIC:
A) Fe Deficiency
B) Thalassemia
C) Lead Poisoning
2) NORMOCYTIC:
A) Chronic Disease
B) Renal Disease
C) Infections
D) Acute Blood Loss
3) MACROCYTIC
A) B12, Folic Acid Deficiency
B) Abnormal DNA Synthesis
Microcytic Anemia
- Deficiency of Vitamin B12
- Deficiency of Folic Acid
- Drugs affecting DEOXYRIBONUCLEIC ACID (DNA) Synthesis
- Inherited DISORDER of DNA Synthesis
- LIVER DISEASE
- Hypothyroidism and Hypopituitarism
- Accelerated Erythropoiesis (Reticulocytes)
- Hypoplastic and Aplastic Anemia
- Acute Leukemia
****SMALL RBC that appear Hypochromic (Less Hb in the Cell) and expressed by a lower than normal MCHC
Normocytic Anemia
- Anemia of Chronic Dx
- Endocrine Etiology
- Acute Blood Loss
- RENAL FAILURE
- Hypersplenism
- NEONATAL ANEMIA
- HEMOLYSIS
*****HEMATOCRIT (Packed Cell Volume) and HEMOGLOBIN is DECREASED but NORMAL RBC size!!!!!!!!
Anemia and Iron
IIRON DEFICIENCY:
1) Ferritin (Stores Iron in Cells):
- Low
2) Iron:
- Low
3) TIBC (Total Iron Binding Capacity):
- High
4) Transferrin (Carries Iron in Blood):
- High
CHRONIC Dx:
1) Ferritin:
- High
2) Iron:
- Normal/ High
3) TIBC:
- Low
4) Transferrin:
- Low
THALASSEMIA:
1) Ferritin:
- Normal or High
2) Iron:
- Normal or High
3) TIBC:
- Normal
4) Transferrin:
- Normal
Decreased Production of RBCs
1) Infiltration of Marrow
- Neoplasia, Myelofibrosis
2) Hyperplastic Marrow (Response to decrease in RBC)
- B12, Foalte, Fe Deficiency
3) Aplastic/ Hypoplastic Marrow- Pure RBC Aplasia (Bone Marrow Damaged)
- Acquired ACUTE RBS Hypoplasia
4) Aplastic/ Hypoplastic Marrow- Familial (Bone Marrow Damaged)
- Diamond/ Backfan
- Falcon
- Congenital Pancytipenia
5) Aplastic/ Hypoplastic Marrow (Drugs/ Idiopathic)
- Antibiotics, Dilatin, Viral Hepatitis
6) Aplastic/ Hypoplastic Marrow- Dose Related
- Heavy Metals, Benzene, Antimetabolites
Some Hemolytic Causes
1) Sickle Cell (Hemoglobin S)
2) Hereditary Spherocytosis ( Autosomal Dominant, mutation in genes that allow RBC to change shape)
3) G6PD
4) Pyruvate Kinase Deficiency (RBC break down too easily)
5) Microangiopathic Disorders (RBC Destruction caused by factors in Small Vessels)
A) DIC
B) Hemolytic Uremic Syndrome
C) TTP
6) Mechanical Hemolysis
7) Paroxysmal Nocturnal Hemoglobinuria (Destruction fo RBC by Complement System)
Intracorpuscular Defect
HEREDITARY:
- Hereditary Spherocytosis
- Hereditary Elliptocytosis
- Hemoglobinopathies
- Thalassemias
- Congenital Dyserythropoietic Anemias
- Hereditary RBC Enzymatic Deficiencies
- Rarer Hereditary Abnormalities
ACQUIED:
- Vitamin B12 and Folic Acid Deficiency
- Paroxysmal Nocturnal Hemoglobinuria
- Sever Iron Deficiency
Extra corpuscular Defects
- Physical Agents: Burns, Cold Expose
- Traumatic: Prothetic Heart Valves, March Hemoglobinuria
- Chemicals: Drugs and Venom
- Hepatic and Renal Disease
- Malignancies: Particualrly Hematologic Neoplasia
- Transfusion of Incompatible Blood
- Hemolytic disease of Newborn
- Cold Hemagglutinin Disease
Nutritional Etiologies
- Iron Deficiency
- Vitamin B12 Deficiency
- Folate Deficiency
- Starvation and Generalized Malnutrition
Physical Etiologies
- Trauma
- Burns
- Frostbite
- Prosthetic Valves and surfaces
Elements of Social History
- Demographics and Occupational History
- Nutrition and diet
- Daily activities and exercise
- Alcohol, Tobacco, and recreational drug use
- Spirituality and beliefs
- Relationships
- Sometimes: Sexual History
Demographics
- Age
- Gender
- Race or Ethnic Background
- Religion/ Spirituality
- Residence
Occupational History
- Do you work outside your home?
- What kind of work do you do?
- Tell me what your job is like for you?
- Ever been exposed to fumes, chemical, dust, loud noise or radiation?
The BIGGIE!!!
- Do you think anything at work or home is AFFECTING your SYMPTOMS!!!