WEEK 3: Epithelial Tissues (Lecture) Flashcards
composed of closely aggregated polyhedral cells adhering strongly to one another and to a thin layer (small amount) of ECM, forming cellular sheets that line the cavities of organs and cover the body surface.
Epithelial Tissues
The principal functions of the epithelial tissues include the following: CAS
Covering, lining and protecting surfaces
Absorption
Secretion
All epithelial cells don’t have veins or also called ______
avascular
All epithelial cells undergo _____. Under certain abnormal conditions, one type of epithelial tissue may undergo transformation into another type in another reversible process called _____.
metaplasia
Epithelial Cell Junction.
Function: Seals adjacent cells to one another, controlling passage of molecules between them; separates apical and basolateral membrane domains.
Junctional protein: Occludins, claudins and ZO proteins
Tight Junction (Zonula Occludens)
Epithelial Cell Junction.
Function: Provides points linking the cytoskeletons of adjacent cells; strengthens and stabilizes nearby tight junctions.
Junctional Proteins: E-cadherin, catenin complexes
Adherens Junction (Zonula Adherens)
Epithelial Cell Junction.
Function: Provides points of strong intermediate filament coupling between adjacent cells, strengthening the tissue
Junctional Protein: Desmogleins and Desmocollin
Desmosomes
Epithelial Cell Junction.
Function: Anchors cytoskeleton to the basal lamina
Junctional Proteins: Integrins
Hemidesmosomes
Epithelial Cell Junction.
Function: Allow direct transfer of small molecules and ions from one cell to another.
Junctional Protein: Connexins (1 connexons: 6 connexins)
Gap Junctions or Communicating Junction (Nexus)
Morphology. Thin and flat cells
Squamous
Morphology. Cell width and thickness roughly similar. Square
Cuboidal
Morphology. Cells taller than they are wide. Rectangular
Columnar
One cell layer
Simple epithelia
Two or more cell layers
Stratified epithelia
Surface Modifications. Are long, highly motile apical structures, larger than microvilli, and containing internal arrays of microtubules not microfilaments.
Cilia