Week 3 Chapter 36 MS Disorders Flashcards
Noninflammatory degenerative disorder of the joints
Osteoarthritis
Most common form of joint disease is sometimes called what?
Degenerative Joint disease
Osteoarthritis is classified as either what?
- Primary - idiopathic - no prior event or disease related to the OA
- Secondary- resulting from previous joint injury or inflammatory disease similar to RA
Primary OA does not involve what?
Autoimmunity or inflammation
- Can occur as an end result of an autoimmune disorder where joint destruction occurs
Limited to the affected joints and no systemic symptoms
OA
What is the pathophysiology of OA?
- Articular cartilage breaks down, leading to progressive damage to the underlying bone and eventual formation of osteophytes( Bone spurs) that protrude into the joint space
- Joint space is narrowed, leading to decreased joint movement and the potential for more damage
- Joint can progressively degenerate
- Previously thought of as simply “ wear and tear” r/t aging
Evolution of OA
- Bone
- Cartilage
- Thinning of cartilage
- Cartilage remnants
- Destruction of cartilage
What can illicit a chondrocyte response?
- Mechanical Injury
- Genetic and hormonal Factors
- Previous joint damage
- other
With a chondrocyte response what happens next?
Release of cytokines
What happens after the release of the cytokines?
-Stimulation production and release of proteolytic enzymes, metalloproteases, collagenase
Then resulting damage predisposes to further damage
Characteristic Degenerative Changes “Degradation”
- Cartilage Particles
- Joint space narrowing
- Osteophytes
Name the clinical manifestations of OA
- Pain, stiffness, and functional impairment
- Joint pain aggravated by movement or exercise and relieved by rest
- Morning stiffness is present; usually brief, lasting less than 30 min
- Onset is routinely insidious, progressing over multiple years
- Affected joint may be enlarged with decreased ROM
- Most often in weight bearing joints, ( hips, knees, cervical and lumbar spine)
In OA spine what occurs?
- Bone Spur
- Narrowed disc
Common sites of OA includes where?
- Spine
- Hip
- Hand
- Knee
- Foot
—-Damage to bone and cartilage
Name the causes of OA
- Endocrine- Diabetics prone to OA (acromegaly, hypothyroidism, hyperparathyroidism, obesity)
- Post- Traumatic- Traumatic - Macro/ micro
- Inflammatory Joint Dz: infected joints, gout, rheumatoid dz
- Metabolic: Paget’s or Wilson’s Disease
- Congenital: Abnormal anatomy
- Genetic: Breakdown protective architecture of cartilage
- Neuropathic : Diabetes - nerve problems
RF for OA include
- Older age, female gender, and obesity
- Certain occupations
- Engaging in sport activities
- Hx of previous injuries, muscle weakness, genetic predisposition and certain diseases
- Most prominent modifiable risk factor for OA is obesity
- Diet and exercise can help minimize symptoms of OA in pt with obesity
Name the S/S of OA
- Pain: aching, stiffness, difficulty moving join (Functional impairment)
- Morning stiffness
- Onset is insidious
- Fingers/ Hands : enlarge first joint
Most often in major wt bearing joints( knees, hips, cervical, and lumbar spine)
Heberden’s Node and Bouchard’s Node found in
OA
Herb- Distal -away body
Bouch- Proximal - closer to the body
Management of OA includes
- Decrease pain and stiffness
- Exercise, especially in the form of CV aerobic exercise and lower extremity strength training
- Wt loss
- Occupational and physical Therapy
- Pharmacological management directed toward symptom management and pain control
- Used in conjunction with nonpharm strategies
What kind of diet would one have with OA?
Mediterranean Diet or sometimes called anti-inflammatory diet
Mediterranean Diet Includes
- Fish- inflammation omega 3s
- Nuts and seeds- Inflammation fighting monosaturated fat
- Fruits and veggies –antioxidants
- Olive oil - Heart healthy fats
- Beans - antioxidant and anti inflammatory compounds
- Whole Grains - Fiber, help maintain healthy weight
Surgical management of OA includes ?
- Moderate to sever OA or loss of function
- Osteotomy
- Arthroplasty
Patient Assessment and Diagnostic Findings OA and RA
Hx- onset and evolution of symptoms, family hx, past health hx, and contributing factors