Week 3 Chapter 34 Rheumatic Disorders Flashcards
Encompass autoimmune, degenerative, inflammatory, and systemic conditions
Rheumatic Diseases
Affect the joints, muscles, and soft tissues of the body
More than 100 types of rheumatic diseases
Rheumatic Diseases
Problems caused by rheumatic diseases include:
-Limitations in mobility and activities of daily living
- Pain and fatigue
- Altered self-image
-Sleep disturbances
- Systemic effects that can lead to organ failure and death
How many different arthritis disorders are there?
More than 100
Rheumatic diseases affect the primary joints but also what?
Muscles, bone, ligament, tendons, and cartilage
Remission and exacerbation
Classification of Rheumatic diseases can be
Monoarticular or polyarticular
Inflammatory or noninflammatory
3 distinct characteristics of pathophysiology include
- Inflammation
- Autoimmunity
- Degeneration
Most commonly manifest the clinical features of arthritis (inflammation of a joint) and pain
Marked by periods of remission and exacerbation
Rheumatic Diseases
Classifications of Rheumatic diseases include
Monoarticular or polyarticular
Inflammatory or non inflammatory
What are the 3 distinct characteristics of rheumatologic diseases?
- Inflammation
- Autoimmunity
- Degeneration
What is the pathophysiology physical signs of RA?
-Presentation of antigen to T cells
- T and B cell proliferation in synovial lining
- Neutrophil accumulation in synovial fluid
Cell proliferation
No cartilage invasion
- Synovitis
Early pannus invasion
Chondrocyte activation
Degradation of cartilage by proteinase
–Subchondral bone erosion
Pannus invasion of cartilage
Chondrocyte proliferation
Laxity of ligaments
Name the common symptoms of Rheumatic Disease
Pain
Joint swelling
Limited movement
Stiffness
Weakness
Fatigue
Rheumatic Diseases onset may be what?
Acute or Insidious
Periods of remission or exacerbation
Tx of Rheumatic Diseases can be
Simple
Complex
Patho- Some degree of inflammation caused by immune system and degeneration -secondary process or both
Manifestations of RA
Symmetric joint pain and stiffness lasting for more than a hr
Disease progression of RA includes
Swelling
Warmth
Erythema
Lack of function
Palpated joint feels spongy or boggy
Fluid can be aspirated from inflamed joint
RA have deformities of ?
Hand - Ulnar deviation and swan neck deformity . Thumb boutonniere
Cause: misalignment, progressive joint destruction, subluxation
Differs from OA’s Heberden’s and Bouchard’s
Characteristic patterns of RA
Joint pain in
- Shoulders
- Elbows
- Hands/ wrists
- Hips
- Knee joints
- Foot pain on joints
INFLAMED SYNOVIUM
Manifestations of RA Systemic
Fever
Weight loss
Fatigue
Anemia
Lymph node enlargement
Raynaud’s phenomenon
Rheumatoid nodules