Week 3 - Anti-infective Agents And Cancer Treatment

Question 1

antimicrobial vs. antibiotic

Answer 1

antimicrobial = all microbes
antibiotic = against bacteria

Question 2

gram + vs. gram -

Answer 2

gram + = thick wall / 20-30 strands

gram - = thin / 5-7 strands

Question 3

Selective toxicity

Answer 3

low selective toxicity = kill everything

Question 4

bacteriostatic vs bactericidal

Answer 4

bacteriostatic = inhibit bacterial growth / need host
bactericidal = ill bacteria / no host

Question 5

Tubercolisis (TB)

Answer 5

airborne

tx= isolate

Question 6

MRSA

Answer 6

linezolid

Question 7

C diff

Answer 7

treated by glycopeptides
AE of lincosamide

use chlorine not alcohol
oral, fecal

Question 8

Hepatitis

Answer 8

A = fecal, oral  --> tx:  immunoglobulin
B= blood ---> tx: interferon, (flu symptoms) nucleoside (better tolerated)
C= blood --> DAA

Question 9

influenze

Answer 9

tamiful, xofluza

Question 10

HIV

Answer 10

tx : HAART
adherence
First line tx: Triumeg, Biktarvy

Question 11

Types of vaccination

Answer 11

inactivated (killed pathogen) - multi dose - Hep A, influenza
conjugated or subunit (piece of pathogen) - booster - Hep B
live attenuated (weak pathogen) - lifelong - NMR, varicella
toxoid (pathogen toxin, not actual pathogen) - booster - tetanus
mRNA = vaccin

Question 12

what type of vaccine should be avoid if immunocompromised

Answer 12

live attenuated

Question 13

Antifungal tx

Answer 13

Azole - athlete foot - common CYP interaction and cardiac aeehytmias
Polyene - nystatin - Po or topical - oral thrush
alter cell membrane permeability

Question 14

cancer tx

Answer 14

radiation
surgery
pharmacotherapy

Question 15

cancer tx - type of pharmacotherapy

Answer 15

chemotherapy
targeted therapy
immunotherapy

Question 16

AE of cancer tx

Answer 16

anemia, appetite loss, increased bleeding risk, fatigue, fall, increased risk for infection, decreased cognition