week 3 Flashcards
give examples of depresents
Alcohol, opioids, Benzodiazepines
MOA of benzodiazipine?
GABA agonist
Examples of Stimulants?
Amphetamines, cocaine, MDMA, caffine
Examples of hallucinogens
Cannaboids, LSD, Psilocybin
what is the uk recommendation for alcohol?
14 units per week distributed over a 3 day period
MOA of alcohol
GABA/Benzodiazepine receptor agonist => inhibition of the CNS
NMDA glutamate receptor antagonist => impaired memory coding and retreival
what is the timeline of alcohol withdrawl symptoms?
day 1 = minor symptoms
- Anxiety, insomnia
Hallucinations
Day 2= seizures
Day 3 = Delerium tremens
Define delerium
An acute state of mental confusion
pathogenesis of delerium?
Inflamation impairs BBB, causing CNS inflamation => increased metabolic demand => delerium
Aetiology of delerium?
Infection
Neuro
Metabolic
Endocrine
Nutrition
medication
core clinical features of delerium?
Acute onset
Fluctuates
Cognitive impairment
Clouding of conciousnesss
Psychosis
Emotional dysregularion
managment of delerium
- treat underlying cause
- avoid offending drugs
- constant familiar environment
Define dementia
A Neurodegenerative process
What are the most common types of dementia?
Alzheimer’s dementia
Lewy body dementia
Fronto-temporal dementia
Vascualr dementia
Alcohol related brain injury
What is the dopamine hypothesis for antipsychotics
Psychosis is caused by increased dopamine, therefore antipsychotics work by decreasing dopamine
