Week 3 Flashcards
Life Course Health Development
- Approach to the cause of disease
- Is now focusing on biological psychological and social factors that contribute to disease
- Disease development is multifactorial and there is no “magic bullet” in treatment cure or cause
- Drugs were good for bacteria but not so much for complex chronic disease
Atherosclerosis
A disease that develops in middle age but has its origins in physiology, development social and psychological history
How is resilience Derived
- Multi-factorial
- Early environment, social support, genetics, epigenetics, and coping strategies,
- Also pharmacological and other therapeutic interventions
- Social workers and therapists are key to developing wholistic resilience
Brain at the nexus of stress
- Principle organ involved in identifying stress and managing it
- Can adapt own structure and function and genetics in response to stress or the environment
- This is done with Hormones and Trophic Factors
Trophic Factors
- Any molecule that supports the survival of cells
- Nerve growth factors are polypeptides that regulate the proliferation, survival, migration, and differentiation of cells in the nervous system.
Brain Derived Neurotrophic Factor (BDNF)
- Provides instructions for making a protein in brain and spinal cord
- Promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells.
Depression, PTSD Recovery and Brain Structure
Chronic Stress and Mental Illness causes changes in brain structure and function
These can recover to a certain extent using therapy and relief of stress
Recovery of Structural Markers
- Gene Expression and Epigenetics can rebuild structural makers of positive healing
Epigenetics
Changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself
What Builds Resilience
- Epigenetics and Gene Expression
- Actively engaging in a positive response to stress and trauma is needed to recover structural markers
- Remaining rigid or lacking vulnerability does not allow for neural adaptation
Resilience
The ability to adapt and come to a successful outcome in the face of difficulty or adversity
Eustress
Stressful situations that produce positive outcomes
e.g. Military Boot Camp that pushes participants limits in order to make them more resilient in a combat situation
Allostasis
Returning to a neutral state after experiencing a stressful event
Neuroplastic Adaptation
- Recovery of stress induced changes in the brain’s architecture
- Not a reversal of traumatic damage
- An adaptation towards resilience that requires external intervention
- Impaired by mood disorder and ageing
Characteristics of Resilience
- Making positives out of adverse situations
- Ability to self regulate
- Moderated Locus of Control
Locus of Control
- Accurate perception about the underlying main causes of events in life.
- Accurately decide whether an outcome is contingent on our actions
Rapid activation and rapid, appropriate termination of the stress response are associated with resilience,
Blunted or exaggerated responses are associated with disease states
Neurotransmitters Associated with Resilience
- Neuropeptide Y
- Norepinephrine
- Corticotropin Releasing Hormone
- Endocannabinoid
- Oxytocin
- Glutamate - Most Significant
Resilience in children
- Increased by positive relations to caregivers
- Strong social support
- Community that provides meaningful response to adversity (faith based)
Actions to promote Resilience
- Faith Based engagement like prayer
- Meditation
- Active Coping Engagement
- Exercise
- Actions to develop mastery and self esteem
Absence of Adversity
- Does not necessarily contribute to resilience
- Exposure to controllable adverse events helps
- sheilding and not challenging children does not protect children or build resilience
Environmental Programming
How epigenetics are expressed during development
Two Methods of Inheritance
Slow: many changes across multiple generations
Fast: changes in genetic expression from mother to child