Week 2.5 - Animal Behaviour and Cognition Flashcards
What are Brodmann’s areas?
Parcelations (i.e. divisions) of the neocortex based on cytoarchitecture and lesion studies originally proposed by Korbinian Brodmann.
What is the function of the hippocampus?
It is the area of the brain normally associated with navigation and episodic memory.
What is transcription?
What is translation?
Transcription is the process that sequences RNA on the basis of DNA.
Translation is the creation of a protein from RNA.
What is a Golgi stain?
A method of staining entire neurons so that they can be visualized in a microscope.
Only 10% or so of the neurons are stained, it is a stochastic process.
What is fMRI?
A method of visualizing the activity of the brain using the BOLD (blood oxygenation level-dependent) signal.
What are place cells?
Cells in the hippocampus that are active when an animal occupies a particular place in space.
These cells are thought to act as cognitive representations (cognitive maps) of specific locations in space.
What are grid cells?
Cells in the entorhinal cortex (entry point to the hippocampus) that encode a ‘metric’ that is ‘distance’ in the world.
Below you see firing rate maps of a place cell (left) and grid cell (right). Maps correspond to an overhead view of the chambers. Dark pixels represent a high average firing rate; yellow pixels are 0 spike/sec firing rates.
Cylinder 3 ft diameter; rectangle 4ft x 5 ft. Grid Cell data courtesy of EunHye Park.
What is cognition?
The ability of an animal to meaningfully interact with their environment.
What is studied by the field of epigenetics?
The expression or inhibition of particular genes according to environmental and developmental influences.
What is the default network?
The network of brain regions that is active when a person is not focused on the outside world.
How can we measure default networks?
Using fMRI
What are some of the limitations of using animal models?
(1) It is difficult to assess mood changes in animals (if we are studying mood disorders)
(2) Behavioral tests are often not specific enough
(3) Rodents might react differently to medications compared to humans
(4) Mood disorders are polygenic and multifactorial, making it impossible to use the transgenic method to model them
Which cells are thought to produce the most EEG signals from the cerebral cortex?
Pyramidal cells
This is because they are well-aligned and fire together
What are some of the medical uses of EEG?
(1) It can be used to monitor patients with epilepsy
(2) It can be used to measure the state of consciousness (e.g., comatose state)
What is excitotoxicity?
Damage (and potentially death) of nerve cells as a function of pathologically high levels of neurotransmitters (e.g., glutamate)
In her lecture, professor Badura talked about a method called accumulating towers, where a mouse observes a virtual reality scenario with towers appearing to the left and right.
What is the dependent variable (variable under observation) in this experiment?
Working memory in mice
Indicate whether each of these sentences is true or false:
(1) The core of each neuromodulatory system has a lot of neurons
(2) Each neuron can influence many others
(3) Neurotransmitters are released into the extracellular space
(4) Neurons that produce modulatory neurotransmitters are mostly in the cortex
(1) False
(2) True
(3) True
(4) False
Where does the serotonin system project to?
(1) Cortex
(2) Spinal cord
What are the sites of origin of the dopamine system?
(1) substantia nigra
(2) ventral tegmental area
(image source: Wikipedia)
What are the main functions of the dopamine system?
(1) Motor function
(2) Reward/punishment
(3) Problem-solving
(4) Planning