Week 2 - Organisation of the Cell Flashcards

1
Q

Cells

A
  • Cells are the building blocks for all tissues in our body
  • 37 trillion cells
  • Shape of the cell determines role
  • Work individually and together
  • Two types are; sex cells and somatic cells
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2
Q

Cell structure

A
Cell membrane
Lysosome
Nucleus
Nucleolus
Nuclear membrane
Vacuole
Mitochondria
Golgi body
Ribosomes
Smooth ER
Rough ER
Cytoplasm
Centrosome
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3
Q

Cell membrane

A
  • Lipid bilayer (2 layers of phospholipids)
  • Physically isolates the intracellular environment from the extracellular environment
  • It is semipermeable and allows substances to pass through the membrane
  • It is highly sensitive to environmental changes (pH or chemical composition) and is the first line of defence
  • Helps maintain the shape of the cell
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4
Q

Cytoplasm

A
  • The fluid containing organelles between cell membrane and nucleus
  • Cytosol contains dissolved nutrients, proteins, ions and wastes
  • Cytosol has high concentration of sodium ions
  • Has a high concentration of proteins (enzymes) to help organelles complete specific functions
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5
Q

Nucleus

A
  • Processor of the cell
  • Holds DNA code for all proteins
  • Has a nuclear envelope to separate it from the cytosol
  • Contains nuclear pores allowing chemicals to travel
  • Fluid in nucleus is called nucleoplasm, which has filaments for structure
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6
Q

DNA

A
  • Genetic material of living organisms
  • Organised into chromosomes
  • Somatic cells have 23 pairs of chromosomes
  • Coiled
  • Instructs the cell on the proteins to make to achieve specific functions
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7
Q

Endoplasmic reticulum

A
  • Many proteins need help forming subsequent structures
  • Membrane surrounded organelle that forms a tubular network that begins at nuclear envelope and extends into the cytosol
  • Modifies proteins and helps produce carbohydrates/lipids
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8
Q

Rough ER

A
  • The protein that requires modification is fed directly from ribosome into here
  • Has ribosomes attached to it
  • Modifies proteins using an oxidative environment
  • This environment allows proteins to fold properly and stabilises structure by forming intermolecular bonds
  • Contains enzymes for production of lipid/carbohydrate products
  • Helps detoxify using degradative enzymes. Sending basic constituents back to the cell or into the body for excretion
  • An area of storage for cytoplasmic molecules
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9
Q

Smooth ER

A
  • Makes lipids and carbohydrates

- Has no ribosomes attached

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10
Q

Lysosomes

A
  • Functions to remove wastes
  • Enclosed in a membrane
  • They digest excess or worn out organelles, food particles, and engulfed viruses or bacteria
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11
Q

Peroxisomes

A
  • Present in cytoplasm
  • Contains reducing enzyme catalase
  • Absorb the nutrients that the cell has acquired
  • Digests fatty acids and alcohols
  • More present in the liver cells
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12
Q

Mitochondria

A
  • Site of major ATP production
  • 2 membranes
  • Inner membrane is heavily folded full of hydrogen ions that are critical to producing ATP. Also provides a large surface area when electrons of citric acid cycle and electron transport chain are fixed
  • Contains enzymes to catabolise carbohydrates, proteins and lipids
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13
Q

Golgi body

A
  • Modifies and packages hormones and enzymes for secretion
  • Packaging enzymes in vesicles for use in cytosol
  • Maintains cell membrane
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14
Q

Secretory vesicles

A
  • Vesicles fuse with lipid bilayer to pass contents outside the cell
  • Highly concentrated products to cell membrane
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15
Q

Membrane renewal vesicles

A
  • Can be shipped from golgi apparatus to the lipid bilayer to fuse with cell membrane
  • This helps repair cell membrane from constant damage
  • It helps assist change fluidity of cell membrane to allow certain materials to enter cell
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16
Q

Lysosomes

A
  • Vesicles that contain digestive enzymes to clean the inside of the cell
  • Lysosome membrane enzymes envelop the debris
  • The contents after digestion can be reused or secreted out of the cell
17
Q

Cytoskeleton

A
  • Provides framework to give shape and strength

- Made up of microtubules, intermediate filaments and microfilaments

18
Q

Microtubules

A
  • Microtubules are hollow tubules made of the protein tubulin. They provide the primary structure of the cytoskeleton
  • Microtubules form a dynamic structure that can disassemble and re assemble to change shape of a cell. Allow organelles to move from one place to the other
  • Microtubules assist in the cell division process
19
Q

Microfilaments

A
  • Small protein strands made up by actin
  • Found in outer regions of cells
  • Allows cells to change shape
  • Interact with myosin to produce movement or change its shape
  • Attaches cell membrane to cytoplasm
  • Hydrogen bonding and charge based bonding to engage with proteins in cell membrane
  • Increased microfilaments = thicker consistency
20
Q

Intermediate filaments

A
  • Thicker than microfilaments but not as thick as microtubules
  • Maintains and strengthen shape of cell
  • Stabilises organelles
21
Q

Cilia

A
  • Movement specific organelles of the cells

- Cilia is rigid due to microtubules

22
Q

Ribosomes

A
  • Are a collection of protein and RNA. These subunits come together when protein production is required
  • Role of the ribosomes is to read and translate RNA code to collect and join appropriate amino acid with the ever extending protein chain. Amino acids are joined via peptide bond representing protein primary structure
23
Q

Cardiac muscle

A

High density of mitochondria to produce the high amount of energy for the muscle which is constantly contracting

24
Q

Macrophage

A

Many vesicles which assists in the breakdown of debris in the cell

25
Q

Pancreatic cells

A

Well developed ER, golgi and secretory granules which help produce insulin for the body

26
Q

Squamos epithelial cells

A

Thin and flat appearance for easy diffusion

27
Q

Red blood cells

A

No nucleus because they have a shape to carry haemoglobin through the blood

28
Q

Megakaryocyte

A

Large with a large nucleus as it produces platelets

29
Q

Skeletal muscle

A

Many nuclei as they are large in size

30
Q

Metabolism definition

A

Is the sum of all the chemical reactions that occur in the body

31
Q

Anabolism

A
  • Synthesis of organic molecules
  • Requires energy
  • Maintenance and repair
  • Growth as cells are constantly dividing and increasing in size
  • Secretions
  • Storage for times when nutrients are required in extremes
32
Q

Catabolism

A
  • Breakdown of organic molecules
  • Releases energy
  • Starts in cytosol and finishes in mitochondria, where ATP is produced
  • The ATP is used in the anabolism stage
  • Produces heat energy
33
Q

ATP

A
  • Adenosine triphosphate
  • Organic compound with 3 phosphate groups attached
  • Storage or transfer of energy
  • Energy currency for biological systems
  • Made from ADP and inorganic phosphate constantly replenish ATP stores
34
Q

Cellular metabolism (respiration)

A
  • Produces ATP and high energy compounds
  • Carbohydrates are a large source of ATP and HEC
  • Uses oxygen
  • C6H12O6 + 6O2 <> 6CO2 + 6H2O + ATP
  • Releases 2800KJ/mol or energy
  • Produces 29-38 ATP molecules in ideal circumstances
35
Q

Glycolysis

A
  • Breaking up the glucose molecule, breaking carbon ring into 2 pyruvic acid.
  • Needs 2 ATP molecules but produces 4 ATP
  • Anaerobic process
  • Occurs in the cytosol of the cell
36
Q

Krebs cycle

A
  • The pyruvic acid enters the Krebs cycle which generates another 2 ATP molecules
  • Aerobic process
  • Occurs in mitochondrial matrix
  • Pyruvate is converted to 2 x 2 carbon molecules 2 is breathed out and the other molecule is Acetyl-CoA
  • Acetyl CoA id fed to the first enzyme of the Krebs cycle
  • Also called citric acid cycle
  • NADH and FADH2 are 2 electrons carriers to safely carry electrons from the enzymes in Krebs cycle to Electron transport chain as the electrons are extremely reactive
37
Q

Electron transport chain

A
  • Electron transport chain produces 34 ATPs aerobically
  • Also called oxidative phosphorylation
  • Is a set of enzymes that transfer electrons from one to the other
  • If there is a lack of oxygen in the cycle the glucose becomes lactic acid through fermentation