Week 2; Neural communication Flashcards
2 different types of channels
- leakage channels (always open)
- gated channels (can be opened)
2 different types of gated channels
- chemically gated channels (neurotransmitter attaches to receptor)
- Voltage gated channels (change in membrane potential promotes the opening and closing of the gate
2 types of signals
- Graded potentials, short-term localised changes in membrane potential
- Action potential, long distance signals of axons
Depolarisation
- decrease in membrane potential (moves toward 0 and above)
- Na+ travels into cell through voltage gated channels, depolarising adjacent active sites
- Inside of the membrane being more positive than the resting membrane potential
- higher possibility of an action potential being created
Hyperpolarisation
- increase in membrane potential (away from 0)
- movement of K+ down their concentration gradient and to the outside of the cell
- makes the inside of the cell more negative
- lowers the possibility of producing an action potential
4 steps in an action potential
- resting state
- depolarisation
- repolarisation
- hyperpolarisation
stages in voltage gated Na+ channels
- closed at resting membrane potential
- open by depolarisation
- close by inactivation gate
stages in voltage gated K+ channels
- closed at resting state
- open by depolarisation
2 types of refractory periods
Absolute refractory period; Time taken between start and reset of Na+ channels
Relative refractory period; includes absolute time period, but AP can be produced during this time, only, more stimulus is needed
what is conduction velocity?
the speed at which an action potential moves down an axon
What is myelination?
What are the nodes of ranvier?
Why does myelin speed up conduction velocity?
- Myelin sheath is the plasma membrane of Schwann cells (PNS) and oligodendrocytes (CNS).
- Gaps in myelin are called nodes of ranvier, in these gaps are voltage-gated sodium and potassium channels
- Myelin provides insulin and stops any leakages, it ensures the electrical current stays in the cell and it does not need to be regenerated over time
2 types of conduction
- continuous conduction
- non myelinated, slow
- needs to be regenerated along the length of the axon - salatory conduction
- myelinated, fast
- does not decay and does not need to be regenerated
Synapse definition
a junction that allows electrical signals to be transported from one cell to another. This occurs between a presynaptic and a post synaptic cell, where there is a neuron and an ‘effector’ cell.
two different types of synaptic connections
- axodendritic - between an axon and dendrites
- axosomatic - between axons and soma
6 steps in a chemical synapse
- action potential arrives at the action potential
- voltage gated calcium channels open and Ca enters axon terminal
- Ca entry causes synaptic vesicles to release neurotransmitters via exocytosis
- neurotransmitter diffuses across the synaptic cleft and binds to specific receptors on the post synaptic membrane
- binding of neurotransmitters cause chemically gated channels to open, resulting in graded potentials
- neurotransmitter effects are terminated by uptake through transport proteins, and diffusion away from synapse