Week 2; changes in membrane potential Flashcards
graded potentials
short lived localized signals over short distances. starts at dendrites and soma. They can be depolarization or hyperpolarization. STARTS by a chemically gated ion channel
action potentials
long distance signals of axons, starts at the axon hillock. do not decay over distance, reversal of membrane potential, from negative to positive. principal way neurons send signals.
depolarisation- EXCITATORY
a decrease in membrane potential - closer to 0. Inside of membrane becomes less negative as Na+ channels open, and there is a higher chance of creating an AP
hyperpolarisation - INHIBITORY
an increase in membrane potential - away from one. Inside of membrane becomes more negative as K leaves, less chance of AP
Current
the flow of electrical charge carried by ions
4 stages of an action potential
- rest
- depolarisation
- repolarisation
- hyperpolarisation
3 steps in voltage gated sodium channels
- resting stage activation gate opens
- opened by depolarisation
- inactivation gate closes
propagation of an action potential
sodium channels in one membrane area cause local currents that cause opening of adjacent voltage gated channels
absolute refractory period
time from opening sodium channel until the resetting of the channels, why they dont travel backwards
relative refractory period
whilst hyperpolarising, needs a big stimulus for AP to be created