Week 2 Drugs Flashcards
Lysergic Acid Diethylamide
Serotonin Agonist
Full/partial agonist of 5-HT.2 R
LSD= hallucinogen
Buspirone
Serotonin Agonist
Partial agonist of 5-HT.1A R
(X) antianxiety
Sumatriptan
Serotonin Agonist Agonist of 5HT.1D-R -inhibit release of vasoactive peptides -promote vasoCONSTRICTION (X) migraine headaches (-) nausea, vomiting, dizziness, angina, flushing (O) Recent MI
Fluoxetine
Indirect Serotonin Agonist
SSRI–/ reuptake of serotonin
(X) affective disorders: OCD and panic attacks
(-) sexual dysfunction, nausea
Phenelzine
MAOI—/ metab of serotonin, NE, and DA
X) depression
narcolepsy
(-) food induced hypertensive crisis (pyridines
Cyproheptadine
5HT.2-R Antagonist
(X) allergic skin reactions (pruritis, uticaria)
-Carcinoid
Ondansetron
5HT.3 R Antagonist
X) chemotherapy-induced nausea/vomit (GI and brain R
Alosetron
Selective 5HT.3 Antagonist
(X) women with diarrhea-predominant IBS
(-) severe GI side effects
Nitroglycerin
VasoDILATOR
^ cGMP>relax arterial/venous sm
(X) heart failure
(-) hypotension
venous dominant- reduced preload
Nitroprusside
VasoDILATOR
>*NO–> ^ cGMP> relax arterial/venous sm
(X) hypertensive emergency
(-) hypotension
arterial/venous; ^ SV (reduced pre and after load)
Hydralazine
VasoDILATOR_ direct (^cGMP)
(X) heart failure
(-) hypotension
arterial
Minoxidil
VasoDILATOR_direct “rogaine”(K+channel opener)
(X) Heart failure
HTN
(-) fluid retention
Arterial
Diazoxide
VasoDILATOR_ membrane channel dilator
K+ channel activator
(X) HTN emergency, hypoglycemia
Ca++Channel blockers
VasoDILATORs
- verapamil
- diltiazem
- nifedipine
-increase heart cntxn
- reduced sm cntxn
Arterial
Verapamil
VasoDILATOR_ Ca++ blocker
Phenylalkylamine
Diltiazem
VasoDILATOR_ Ca++ blocker
Benzothiazapine
Milrinone
VasoDILATOR_ PDE 3 inhib
^ cAMP^ heart cntxn, rlxn bv
(X) Heart failure
Inamrinone
VasoDILATOR_PDE 3 inhib
^cAMP^ heart cntxn, rlxn bv
(X) heart failure
Cilostazol
VasoDILATOR_PDE 3 inhib
^cAMP–> ^ heart cntxn, rlxn bv
(X) heart failure
Sildenafil
VasoDILATOR_ PDE 5 inhibitor
^cGMP–> rlxn bv
(X) erectile dysfunction