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Pharmacology Block 2 > Week 2 Drugs > Flashcards

Week 2 Drugs Flashcards

1
Q

Lysergic Acid Diethylamide

A

Serotonin Agonist
Full/partial agonist of 5-HT.2 R
LSD= hallucinogen

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2
Q

Buspirone

A

Serotonin Agonist
Partial agonist of 5-HT.1A R
(X) antianxiety

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3
Q

Sumatriptan

A 
Serotonin Agonist 
Agonist of 5HT.1D-R
-inhibit release of vasoactive peptides
-promote vasoCONSTRICTION
(X) migraine headaches
(-) nausea, vomiting, dizziness, angina, flushing 
(O) Recent MI
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4
Q

Fluoxetine

A

Indirect Serotonin Agonist
SSRI–/ reuptake of serotonin
(X) affective disorders: OCD and panic attacks
(-) sexual dysfunction, nausea

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5
Q

Phenelzine

A

MAOI—/ metab of serotonin, NE, and DA

X) depression
narcolepsy
(-) food induced hypertensive crisis (pyridines

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6
Q

Cyproheptadine

A

5HT.2-R Antagonist
(X) allergic skin reactions (pruritis, uticaria)
-Carcinoid

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7
Q

Ondansetron

A

5HT.3 R Antagonist

X) chemotherapy-induced nausea/vomit (GI and brain R

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8
Q

Alosetron

A

Selective 5HT.3 Antagonist
(X) women with diarrhea-predominant IBS
(-) severe GI side effects

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9
Q

Nitroglycerin

A

VasoDILATOR
^ cGMP>relax arterial/venous sm
(X) heart failure
(-) hypotension

venous dominant- reduced preload

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10
Q

Nitroprusside

A

VasoDILATOR
>*NO–> ^ cGMP> relax arterial/venous sm
(X) hypertensive emergency
(-) hypotension

arterial/venous; ^ SV (reduced pre and after load)

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11
Q

Hydralazine

A

VasoDILATOR_ direct (^cGMP)
(X) heart failure
(-) hypotension

arterial

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12
Q

Minoxidil

A

VasoDILATOR_direct “rogaine”(K+channel opener)
(X) Heart failure
HTN
(-) fluid retention

Arterial

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13
Q

Diazoxide

A

VasoDILATOR_ membrane channel dilator
K+ channel activator
(X) HTN emergency, hypoglycemia

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14
Q

Ca++Channel blockers

A

VasoDILATORs

  1. verapamil
  2. diltiazem
  3. nifedipine

-increase heart cntxn
- reduced sm cntxn
Arterial

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15
Q

Verapamil

A

VasoDILATOR_ Ca++ blocker

Phenylalkylamine

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16
Q

Diltiazem

A

VasoDILATOR_ Ca++ blocker

Benzothiazapine

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17
Q

Milrinone

A

VasoDILATOR_ PDE 3 inhib
^ cAMP^ heart cntxn, rlxn bv
(X) Heart failure

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18
Q

Inamrinone

A

VasoDILATOR_PDE 3 inhib
^cAMP^ heart cntxn, rlxn bv
(X) heart failure

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19
Q

Cilostazol

A

VasoDILATOR_PDE 3 inhib
^cAMP–> ^ heart cntxn, rlxn bv
(X) heart failure

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20
Q

Sildenafil

A

VasoDILATOR_ PDE 5 inhibitor
^cGMP–> rlxn bv
(X) erectile dysfunction

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21
Q

Tadalafil

A

VasoDILATOR_ PDE 5 inhibitor
^cGMP–> rlxn bv
(X) erectile dysfunction

22
Q

ACE Inhibitors

A

VasoDILATOR_ Angiotensin Converting Enzyme inhib

23
Q

Fenoldopam

A

VasoDILATOR_ D.A1 R agonist

(X) hypertensive crisis

24
Q

Prazosin

A

VasoDILATOR_ a-adrenergic blocker

(X) HTN

25
Q

Albuterol

A

BronchoDILATOR_ B2 agonist

26
Q

Pirbuterol

A

BronchoDILATOR_ B2 agonist

27
Q

Terbutaline

A

BronchoDILATOR_ B2 agonist

28
Q

Salmeterol

A

BronchoDILATOR_ B2 agonist

29
Q

Formoterol

A

BronchoDILATOR_ B2 agonist

30
Q

Ipratropium

A

BronchoDILATOR_ Anti-cholinergic

31
Q

Tiotropium

A

BronchoDILATOR_ Anti-cholinergic

32
Q

Theophylline

A

BronchoDILATOR_ methylxanthine

33
Q

Aminophylline

A

BronchoDILATOR_ methylxanthine

34
Q

Aliskiren

A

Renin inhibitor
(blocks angiotensinogen> angiotensin I)
(X) HTN
(-) minimal side effects ~ placebo

35
Q

Losartan

A 
Angiotensin AT.1-R blocker
(X) essential HTN 
Heart failure 
(-) dizziness, cough, angioedema
(O) pregnancy
36
Q

Captopril

A 
ACE inhibitor
(X) essential HTN
Heart failure
(-) rash, proteinuria, neutropenia, cough, angioedema
hyperkalemia
37
Q

Enalapril

A 
ACE inhibitor_ prodrug
(X) essential HTN
Heart failure
(-) rash, proteinuria, neutropenia, cough, angioedema
hyperkalemia
38
Q

Lisinopril

A 
ACE inhibitor_ prodrug
(X) essential HTN
Heart failure
(-) rash, proteinuria, neutropenia, cough, angioedema
hyperkalemia
39
Q

Spironolactone

A

Aldosterone inhibitor_ MC-R antagonist

(X) diuretic, HTN

40
Q

Eplerenone

A

Aldosterone inhibitor_ MC-R antagonist

(X) diuretic, HTN

41
Q

Propranolol

A

B- adrenergic blocker (1st gen)

—/ renin release

42
Q

Metoprolol

A

B-adrenergic blocker (1st gen)

—/ renin release

43
Q

Desmopressin

A

ANTI-diuretic
intranasal
(X) NEUROgenic diabetes insipidus
(X) pre-op prophylactic for hemophilia (^ vonW factor and VIII)

44
Q

Phenylalkylamines

A

Calcium Channel Blocker (CCB)

Verapamil

45
Q

Benzothiazepines

A

Calcium Channel Blocker (CCB)

Diltiazem

46
Q

1,4- Dihydropyridines

A

Calcium Channel Blocker (CCB)

Nifedipine, Amlodipine

47
Q

Verapamil

A

Phenylalkylamine_ myocardial CCBs
(-) heart block
(O) hypotension, bradycardia, conduction defect, cardiac failure

48
Q

Diltiazem

A

Benzothiazepines_myocardial CCBs
(-) heart block
(O) hypotension, bradycardia, conduction defects, cardiac failure

49
Q

Nifedipine

A

1,4 dihydropyridine_ CCB

50
Q

Amlodipine

A

1,4 dihydropyridine_ CCB

Pharmacology Block 2 (7 decks)

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