Week 2 Content Flashcards
- Intrauterine development ⚬ 3 Stages:
■ Ovum/preembryonic
* Conception to day 14
* Cellular replication, blastocyst formation, initial development of embryonic membranes, primary germ layers
■ Embryo
* Day ___ to 8 weeks after conception
* Development of orang systems (organogenesis) and external features
* Most susceptible to environmental teratogens
■ Fetus
15
Membranes
⚬ Chorion - covering of fetal side of placenta
⚬ Amnion - amniotic cavity
⚬ Chorion - covering of fetal side of placenta
⚬ Amnion - amniotic cavity
- _________ fluid
⚬ Initially diffusion from maternal blood
⚬ Fluid secreted by fetal respiratory and GI tract
⚬ 700-1,000 mL at term
⚬ < 300 mL oligohydramnios
⚬ > 2,000 mL (poly)hydramnios
Amniotic
- Umbilical cord
⚬ Supplies the embryo with maternal ___________ & __________
⚬ vessels : ________
⚬ Wharton’s jelly
⚬ Nuchal cord
⚬ Supplies the embryo with maternal nutrients and oxygen
⚬ 2 arteries, 1 vein
⚬ Wharton’s jelly
⚬ Nuchal cord
Placenta
Function
⚬ Endocrine gland
■ Produces ____________ to maintain pregnancy
⚬ Metabolic function
■ ____________, nutrition, excretion, and storage
* Has a finite life - the placenta ages
⚬ Endocrine gland
■ Produces hormones to maintain pregnancy
⚬ Metabolic function
■ Respiration, nutrition, excretion, and storage
* Has a finite life - the placenta ages
Non-genetic Factors Influencing Development
- ______________
⚬ Drugs
⚬ Chemicals
⚬ Infection
⚬ Exposure to radiation
⚬ Maternal conditions - Maternal nutrition
⚬ ____________
- Teratogens
⚬ Drugs
⚬ Chemicals
⚬ Infection
⚬ Exposure to radiation
⚬ Maternal conditions - Maternal nutrition
⚬ Malnutrition
Reproductive System Changes - Uterus
⚬ Palpation
■ Palpated at level of the umbilicus at 20 weeks gestation
■ Reaches the level of the xiphoid process by 36 weeks
⚬ Helps to confirm ____________________________
- Uteroplacental blood flow
- Changes related to presence of fetus
⚬ Ballottement
⚬ Quickening
the estimated date of delivery (EDD or EDB)
Reproductive System Changes - Cervix
signs of pregnanct
- _________ sign - softening of cervix
- ___________ sign - blue vagina/cervix
- _________ fills the cervical canal and protects the fetus from infection - operculum
- Goodell sign - softening of cervix
- Chadwick’s sign - blue vagina/cervix
- Mucous fills the cervical canal and protects the fetus from infection - operculum
Reproductive System Changes - Breasts
- Breasts change in size and appearance.
- _________ stimulates growth of mammary tissue.
- ____________ stimulates growth of lobes, lobules, and alveoli.
- __________ present at 12-16 weeks
- Breasts change in size and appearance.
- Estrogen stimulates growth of mammary tissue.
- Progesterone stimulates growth of lobes, lobules, and alveoli.
- Colostrum present at 12-16 weeks
Cardiovascular System
- Blood volume
⚬ _________
■ Plasma volume expansion results in physiologic anemia. - Cardiac output
- Blood pressure
⚬ Expanded blood volume increases _____________ but not blood pressure
⚬ Venous pressure
⚬ Supine hypotensive syndrome
■ Gravid uterus partially occludes the vena cava and aorta when mother is supine. - Structural adaptations
⚬ Changes related to ___________ workload of the heart and size of the uterus
⚬ S1, S2, and potential S3 present - Increase in ________ factors and fibrinogen
- Blood volume
⚬ Increases
■ Plasma volume expansion results in physiologic anemia. - Cardiac output
- Blood pressure
⚬ Expanded blood volume increases cardiac output but not blood pressure
⚬ Venous pressure
⚬ Supine hypotensive syndrome
■ Gravid uterus partially occludes the vena cava and aorta when mother is supine. - Structural adaptations
⚬ Changes related to increased workload of the heart and size of the uterus
⚬ S1, S2, and potential S3 present - Increase in clotting factors and fibrinogen
Respiratory System
- Diaphragm changes
- Slight hyperventilation and decreased airway resistance allow oxygen needs to be met.
- Oxygen consumption increases by about ____%
⚬ ______ of this oxygen is used by the uterus, fetus, and placenta.
⚬ The remainder is consumed by breast tissue and increased cardiac, renal, and respiratory
maternal demands. - Maternal symptoms
⚬ _______ congestion - Rhinitis of pregnancy
■ Cause of pregnancy-induced nasal symptoms is not entirely understood
■ Thought to be caused by changing hormone levels: estrogen and progesterone.
- Diaphragm changes
- Slight hyperventilation and decreased airway resistance allow oxygen needs to be met.
- Oxygen consumption increases by about 20%
⚬ Half of this oxygen is used by the uterus, fetus, and placenta.
⚬ The remainder is consumed by breast tissue and increased cardiac, renal, and respiratory
maternal demands. - Maternal symptoms
⚬ Nasal congestion - Rhinitis of pregnancy
■ Cause of pregnancy-induced nasal symptoms is not entirely understood
■ Thought to be caused by changing hormone levels: estrogen and progesterone.
GI System
- Mouth - hyperemia of ______
- Effects of prenangy hormones
⚬ _________
⚬ Relaxation of esophageal sphincter
⚬ Nausea/vomiting - Stomach displacement
- Hypotonic gallbladder
- Mouth - hyperemia of gums
- Effects of prenangy hormones
⚬ Pyrosis
⚬ Relaxation of esophageal sphincter
⚬ Nausea/vomiting - Stomach displacement
- Hypotonic gallbladder
Urinary System
- ________ workload
- Physical changes
⚬ __________ on the ureters and bladder due to the growing fetus - Risk factors
⚬ Increased risk for ________________
■ UTI and kidney infections are one of the most common reasons for non-OB hospitalizations - Increased glomerular filtration rate may result in spilling of glucose and other nutrients into the urine.
- Heavier workload
- Physical changes
⚬ Pressure on the ureters and bladder due to the growing fetus - Risk factors
⚬ Increased risk for urinary tract infections
■ UTI and kidney infections are one of the most common reasons for non-OB hospitalizations - Increased glomerular filtration rate may result in spilling of glucose and other nutrients into the urine.
Integumentary, Musculoskeletal, & Neurologic System
- ______________ during pregnancy - melasma, striae gravidarum, and linea nigra.
- Ribs flare, substernal angle widens, and chest circumference increases.
- Muscle strain and __________ may occur during the last trimester.
- Changes in the maternal body may result in a negative body image.
- Maternal symptoms
⚬ Increased sense of ________
⚬ ________ in hands and feet
- Hyperpigmentation during pregnancy - melasma, striae gravidarum, and linea nigra.
- Ribs flare, substernal angle widens, and chest circumference increases.
- Muscle strain and backache may occur during the last trimester.
- Changes in the maternal body may result in a negative body image.
- Maternal symptoms
⚬ Increased sense of smell
⚬ Edema in hands and feet
Endocrine System
- Thyroid
- Pituitary
⚬ Anterior
■ Prolactin - prepares breasts for ___________
⚬ Posterior
■ Oxytocin - Stimulates uterine __________
- Stimulates ______ ________ from breasts after birth
- Stimulates let-down reflex
- Pancreas
- Thyroid
- Pituitary
⚬ Anterior
■ Prolactin - prepares breasts for lactation
⚬ Posterior
■ Oxytocin - Stimulates uterine contractions
- Stimulates milk ejection from breasts after birth
- Stimulates let-down reflex
- Pancreas
- 4 hormones necessary to maintain pregnancy & support embryo/fetus
⚬ Human chorionic gonadotropin (hCG)
■ Preserves the function of the ovarian corpus luteum
■ Ensures a continued supply of estrogen and progesterone needed to maintain pregnancy
- up to 8th week.
■ Hormone identified in pregnancy tests
⚬ Human chorionic somatomammotropin (hCS) or human placental lactogen (hPL)
■ Stimulates maternal metabolism to supply needed nutrients for fetal growth.
■ Increases the resistance to insulin
* Facilitates glucose transport across the placental membrane
■ Stimulates breast development
* Prepares for lactation - 2nd trimester
⚬ Progesterone
■ Maintains the endometrium, decreases the contractility of the uterus, and stimulates
maternal metabolism and development of breast alveoli
⚬ Estrogen
■ Stimulates uterine growth and uteroplacental blood flow, causes proliferation of the breast
glandular tissue, stimulates myometrial contractility.
______________________
■ Preserves the function of the ovarian corpus luteum
■ Ensures a continued supply of estrogen and progesterone needed to maintain pregnancy
- up to 8th week.
■ Hormone identified in pregnancy tests
______________________
■ Stimulates maternal metabolism to supply needed nutrients for fetal growth.
■ Increases the resistance to insulin
* Facilitates glucose transport across the placental membrane
■ Stimulates breast development
* Prepares for lactation - 2nd trimester
______________________
■ Maintains the endometrium, decreases the contractility of the uterus, and stimulates
maternal metabolism and development of breast alveoli
______________________
■ Stimulates uterine growth and uteroplacental blood flow, causes proliferation of the breast
glandular tissue, stimulates myometrial contractility.
- Increased human chorionic gonadotropin (hCG) and estrogen levels may cause nausea in early pregnancy.
- Increased progesterone causes relaxation of smooth muscle, resulting in stasis of urine and constipation.
- ___________ maintains the uterine lining, prevents contractions, and helps prepare breasts for lactation.
Progesterone
- Diagnosis of Pregnancy
⚬ ___________________________ - earliest biochemical marker of pregnancy
■ Pregnancy tests based on recognition of hCG or β subunit of hCG
■ Can be detected in serum or urine as early as 7 to 8 days after ovulation
Human chorionic gonadotropin (hCG)
Estimating date of birth (EDB)
⚬ Formulas for calculating EDB but none infallible
⚬ _________ rule
■ Determine first day of last menstrual period (LMP), subtract 3 months, add 7 days plus 1 year
■ Alternatively add 7 days to LMP and count forward 9 months
⚬ Formulas for calculating EDB but none infallible
⚬ Nägele’s rule
■ Determine first day of last menstrual period (LMP), subtract 3 months, add 7 days plus 1 year
■ Alternatively add 7 days to LMP and count forward 9 months
Patient 1: LMP is reported to be February 14, 2024.
What is the EDB?
Patient 2: LMP is reported to be October 1, 2023.
What is the EDB?
Patient 3: LMP is reported to be June 28, 2024.
What is the EDB?
________
G = Gravida: the number of pregnancies, including this one
T = Term: the number of pregnancies that ended in term births (37 weeks 0 days and beyond; including early, full, late term, or postterm births)
P = Preterm: the number of pregnancies that ended in preterm birth (between 20 weeks 0 days and 36 weeks 6 days gestation)
A = Abortion: the number of pregnancies that ended in miscarriage (spontaneous abortion), elective termination (therapeutic abortion) before 20 weeks or less than 500 g at birth
L = Living: the number of children currently living
GTPAL
- ___________ – may be pregnant
⚬ Subjective changes felt by the woman (patient)
⚬ Amenorrhea
⚬ Nausea and vomiting
⚬ Fatigue
⚬ Urinary frequency
⚬ Breast and skin changes
⚬ Vaginal and cervical color changes
⚬ Fetal movement/Quickening
Presumptive
- ________ - very likely pregnant
⚬ Changes observed by an __________ (MD, Midwife, Nurse)
⚬ Goodell/Chackwick/Hegar’s sign
⚬ Positive pregnancy tests
⚬ Braxton Hicks
⚬ Ballottement
Probable - very likely pregnant
⚬ Changes observed by an examiner (MD, Midwife, Nurse)
⚬ Goodell/Chackwick/Hegar’s sign
⚬ Positive pregnancy tests
⚬ Braxton Hicks
⚬ Ballottement
- ________ - surely pregnant
⚬ Attributed to presence of the _______
⚬ Auscultation of fetal ______ sounds
⚬ Fetal ___________ felt by examiner
⚬ Visualization of fetus (__________)
- Positive - surely pregnant
⚬ Attributed to presence of the fetus
⚬ Auscultation of fetal heart sounds
⚬ Fetal movements felt by examiner
⚬ Visualization of fetus (ultrasound)