Week 2 Flashcards
Urbach-Wiethe disease
entirely lesions both amygdalae
no fear experience
cant recognise fear in others’ faces
put self in dangerous sityations
assymetry of possible outcomes
real vs no danger
strong vs weak fear reaction
factors that increase general risk for anxiety disorders
behavioural conditioning
genetic vulnerability
disturbances in the activity in the fear circuit of the brain
decreased GABA and serotonin, increased norepinephrine
behavioural inhibition
neuroticism
cognitive factors- sustained negative beliefs; perceived lack of control and attention to cues of threat
prefrontal-amygdala connectivity
medial PFC fails to down regulate an overexcitable amygdala
personality risk factors
neuroticism
behavioural inhibition
intolerance of uncertainty
perfectionism
behavioural inhibition
tendency to experience anxiety responses in response to uncertain or unfamiliar stimuli
intolerance of uncertainty
tendency to treat uncertain situations as inherently aversive and act to avoid them
Barlow’s triple vulnerability model
Diathesis: generalised biological vulnerability; generalised psychological vulnerability; specific psychological vulnerability
stress: stressful life event
Barlow’s triple vulnerability model: generalised biological vulnerability
prefrontal-amygdala connectivity
neuroticism
tendency to panic
Barlow’s triple vulnerability model: generalised psychological vulnerability
ease of fear conditioning
lack of control
attention to threat
Barlow’s triple vulnerability model: specific psychological vulnerability
focus of anxiety (for phobias mainly)
DSM-5 TR diagnostic criteria for GAD
- apprehensive expectation; more days than not for at least 6MO, about many events
- difficult to control worry
- 3+ of these symptoms (some present more days than not for past 6MO): restlessness; easily fatigues; difficulty concentrating; irritability; muscle tension; sleep disturbance
- clinically significant distress or function impairment
- not attributed to substance effects or other medical condition
- not explained by another mental disorder
Benzodiazepines for GAD
increase GABA
ACT GAD
focuses on letting go of attempt to rid oneself of unpleasant thoughts
MCT GAD
focuses on our thought about thinking, emphasising positive metacognition rather than negative