Week 14

Question 1

What are designer drugs often developed as?

Answer 1

derivatives of other drugs of abuse or medications

Question 2

Where are designer drugs available?

Answer 2

on the street and over the internet

Question 3

What are designer drugs perceived as?

Answer 3

Safe, but can be lethal and are often not detected in urine drug screens

Question 4

What is MDMA also known as?

Answer 4

Ecstasy, Molly - increases serotonin levels (fever, seizure, coma & death)

Question 5

What is the primary mechanism of action for GHB?

Answer 5

activation of the GABA receptor, rapid onset, causing disinhibition, amnesia and sexual arousal

Question 6

What receptor does Phenibut act at?

Answer 6

GABA receptor

Question 7

Where can you get Dextromethorphan and what does it cause?

Answer 7

Over the counter in cough syrup and can cause hallucinations, mood lability and dissociation.

Question 8

What is the mechanism of action of PCP and ketamine?

Answer 8

glutamate antagonists and are dissociatives, and can cause paranoia.

Question 9

What are Cathinones derived from?

Answer 9

Stimulant derived from the khat plant.

Question 10

What is kratum when at low doses?

Answer 10

stimulant properties

Question 11

what is kratum at high doses?

Answer 11

mu-opioid agonist activity

Question 12

What are increases in fatal opioid overdoses being cause in large part by?

Answer 12

fully synthetic opioids (fentanyl, carfentanil)

Question 13

What 2 substances are hallucinogens that activate serotonin

Answer 13

LSD & 2C-analogue (NBOM)

Question 14

What does Acamprosate (Campral)balance?

Answer 14

GABA and Glutamate

Question 15

How would Campral help patients with alcohol use disorders?

Answer 15

????

Question 16

What is the method of action for naltrexone/vivitrol?

Answer 16

Antagonist - blocks the opioid receptor

Question 17

What is the method of action for suboxone?

Answer 17

Partial agonist - binds to the opioid receptor

Question 18

What is the method of action for methadone?

Answer 18

full agonist at the opioid receptor

Question 19

How does Antabuse work?

Answer 19

alters the metabolism of alcohol making ingestion of alcohol unpleasant

Question 20

Between Acamprosate and Naltrexone, which one is better for reducing heavy drinking?

Answer 20

Naltrexone

Question 21

Between Acamprosate and Naltrexone, which one is better for abstinence?

Answer 21

Acamprosate

Question 22

True or false - Acamprosate and Naltrexone work better if detoxed and can improves by 15%

Answer 22

True

Question 23

Benefits of methadone

Answer 23

reduced illicit opiate use, reduced mortality, reduced crime rates, reduced health care costs, increased employment, better outcome for pregnant women and their infants.

Question 24

Benefits of suboxone over methadone?

Answer 24

less risk of OD and death, fewer interactions with other med, even better outcome for pregnant women

Question 25

What is the method of action of naloxone (Narcan)?

Answer 25

Mu-opioid receptor antagonist. It is either used in spray or it is also in suboxone