Week 12 - Behavioural Genetics Flashcards

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1
Q

It is no longer a question of “Nature or Nurture”. Now we want to know:

A

What is the relative contribution of nature and nurture (of genes and environment)? What are the mechanisms by which they interact to affect biology and behaviour?

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2
Q

DNA is a polymer of four types of nucleotides, what are they?

A

adenine (A), guanine (G), thymine (T) and cytosine (C)

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3
Q

How do nucleotides form bonds?

A

A with T and C with G.

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4
Q

what is most important for DNA coding?

A

The order in which nucleotides are found along the strand (the sequence).

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5
Q

How do mutations occur?

A

When a cell divides, the DNA helix is “unzipped” so that a new complementary strand can be made. Sometimes errors are made when the new strand is made so that the new strand is not exactly the same. Most of the time, a repair enzyme can fix this error, but sometimes the error is not caught which results in mutation.

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6
Q

The process of creating RNA from DNA is called what?

A

Transcription.

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7
Q

What is RNA?

A

a single strand chemical that can serve as a template for the synthesis of proteins.
It has the same bases, except thymine, instead, it has a nucleotide called uracil.

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8
Q

By the process of translation what happens?

A

the protein-building information in an mRNA is decoded (translated) into a sequence of amino acids.

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9
Q

What is a codon?

A

“the genetic words”, carries protein building information, is three bases long (e.g. A-C-G).

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10
Q

What is a base-pair substitution?

A

A mutation in which one nucleotide and its partner are replaced by a different pair.

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11
Q

What is an allele?

A

A variant of a gene.

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12
Q

Being homozygous for a gene means that…

A

a person has an identical pair of genes (or alleles) on the two chromosomes.

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13
Q

Being heterozygous for a gene means that…

A

a person has an unmatched pair of genes (or alleles) on the two chromosomes.

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14
Q

What do period genes do?

A

produce proteins called PER

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15
Q

What do timeless genes do?

A

produce proteins called TIM

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16
Q

PER and TIM proteins both promote what?

A

Inactivity and sleep.

17
Q

Increased levels of PER and TIM lead to decline in what?

A

mRNA.

18
Q

What is Familial advanced sleep phase disorder (FASD)?

A

Proband participated in time-isolation experiment for three weeks (environment with no time cues) and showed a ~1 hour shortening in her circadian period. A mutation in the Per2 gene was identified.

19
Q

What is Familial natural short sleepers (FNSS)?

A

A mutation in the DEC2 gene found. Carriers in a small family needed only ~6 hours of sleep per day.

20
Q

What did the Twin studies of sleep find?

A

Up to 54% of the variance in morningness-eveningness (night owl or morning lark) is heritable.

21
Q

What is Brain-Derived Neurotrophic Factor (BDNF)?

A

A neurotrophin important in neurogenesis and plasticity.