Week 11 Surgery Anaesthetics Flashcards
The three main anatomical/ structural divisions of the brain?
Cerebrum
Brainstem
Cerebellum
The brain stem is composed of the?
Midbrain
Pons
Medulla Oblongata
The cerebellum, which consists mainly of…………….controls………………?
Neurons and controls muscle coordination, maintenance of muscle tone and posture
Functions of the hypothalamus?
Major controller of homeostasis, controller of Autonomic Nervous System (ANS); smooth muscle tone, temperature, cardiovascular and gut functions
Pituitary Gland, thereby controlling endocrine functions; growth, reproductive and sexual functions
A general anaesthetic produces a reversible state of?
Unconsciousness with absence of pain sensation over the entire body
Which of the following statements relating to the blood-brain barrier (BBB) are TRUE? (Select all that apply)
a) is a selective permeability barrier
b) is characterised by astrocyte foot processes and tight junctions between endothelial cells of the cerebral capillary vessels
c) is fully developed at birth
d) contains transporters for the uptake of essential nutrients
e) excludes lipophilic drugs
f) contains drug efflux transporters such as P-glycoprotein
a) b) d) f)
Which of the statements relating to CNS neurotransmitters is TRUE? (Select all that apply)
a) are synthesised in the periphery and taken up into the CNS by transporters in the blood-brain-barrier
b) are stored in vesicle located in nerve terminals
c) Are continuously released into the synapse when the neuron is stimulated electrically
d) Propagate an action potential in the postsynaptic neuron
e) Rely solely on metabolism within the synapse for termination of their response
c) d)
Acetylcholine receptor type or descriptor?
Muscarinic receptors
Adenosine receptor type/ descriptor?
GABAa and GABAb receptors
Noradrenaline receptor?
a2 receptors (auto inhibitory)
Enkephalins, endorphins receptor?
Opioid receptors
Endocannabonoid receptors?
CB1 receptor
Indolamine (serotonin) receptors?
5-HT receptors
