Week 10: OAEs and audiogram Flashcards

1
Q

discordance vs concordance of test batteries

A
  • discordance= the inconsistency between two or more test procedures
  • concordance= the consistency between two or more test procedures
  • –discordance between the PTA and WRS can help identify retrocochlear pathology
  • –discordance also underlies the differential diagnostic capability of objective tests like OAE measurement
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2
Q

strengths of OAEs in clinical practice

A
  • objective measure:
  • –require no behavioral response
  • –uninfluenced by patient motivation, cognitive status, state of arousal, pt’s native language, motor status
  • very sensitive to OHC dysfunction
  • valid test for infants and young children*brie test
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3
Q

weaknesses of OAEs and clinical practice

A
  • not a true measure of hearing
  • abnormal finding does not invariably indicate hearing loss
  • as a single measure generally provides limited info on hearing loss
  • no info on speech perception or understanding
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4
Q

TEOAEs for normal vs hearing impaired

A
  • optimize distinction between normal and impaired cochlear function
  • –80-82 dB peSPL for click stimuli
  • interpreting result
  • –overall hearing is better than 20 dB HL (TEs are present in 99% of ears)
  • –SNHL greater than 40 dB HL (TE are always present)
  • –SNHL 25-35 dB HL (maybe present, but mostly absent)
  • –SNR of less than 6 dB and reproducibility of less than 70%= detect 96% of patients with hearing threshold more than 20 dB HL
  • –sensitive to hearing loss at 1000-4000 Hz
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5
Q

DPOAES: normal vs hearing impaired

A
  • primary stimulus levels
  • –optimal level: L1 between 50-70 dB SPL, L2 10-15 dB softer
  • —–best to differentiate hearing and hearing loss: L1 of 65 and L2 of 55
  • —-other reports show lower levels are more sensitive to HL, but fewer responses
  • high level (70-75 dB) stimulation cause more response and more artifact
  • –not as accurate of eval of hair cell function
  • present with thresholds under 20
  • with SNHL over 50 they are always absent
  • SNHL 25-45 may be present
  • normative data (L1 of 65 and L2 of 55)
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6
Q

TEOAE vs DPOAE

A

*generally if one is present the other will be as well
*changes in either from baseline of 4 dB or more shows changes in cochlear or middle ear function
*choosing a test based one the purpose
*sensitivity to hearing loss:
—1000 Hz= TEs
2000-4000= DP and TE
4000-6000 DP

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7
Q

ecochg

A
  • helpful in differential dx because it allows to record potentials from the cochlea and auditory nerve
  • cochlear microphonic
  • summating potential
  • compound action potential
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8
Q

OAEs vs CM

A
  • both evaluate OHCs
  • CM
  • –not very frequency specific
  • —-moderate to loud stimuli result in increased basal-ward excitation of the traveling wave (making it harder to identify the site of lesion)
  • OAEs
  • –much easier to record
  • –more frequency specific
  • –however, OAEs are easily affected by hearing loss
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9
Q

middle ear pressure and OAEs

A
  • changes in middle ear pressure will change transmission characteristics (highest amplitude at 0 daPa)
  • ME pressure reduces emission amplitude
  • –TEOAEs are generally not detected in case of pressure worse than -200daPa
  • low freqs are affected more than high because you are adding stiffness to the system so low freqs suffer and highs travel easier
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10
Q

ventilation tubes and OAEs

A
  • presence of a response is related to time since surgery and tube type
  • –if TEs are tested immediately, less likely to be present (20%)
  • –if testing about a month after surgery, more likely to be present (80%)
  • –DP amplitude increases right after surgery and keeps increasing
  • –grommets dont affect response as much as t-tubes
  • with an open tube and no pathology, OAEs can be recorded, but the amplitude us likely to be reduced, especially at low freqs
  • normal OAEs indicate the tube is open and there is no middle ear pathology and functioning OAEs
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11
Q

TM perforation and OAEs

A

can be recorded if there is a small perf

  • amplitude may not be affected, but is likely reduced
  • if active otitis media exists, OAEs should not be recorded
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12
Q

OAEs with otitis media

A
  • DPs and TEs are usually absent with OM
  • –forward transmission can be compensated for by increasing stimulus levels
  • –can’t really compensate for loss in backward transmission, except to try to reduce noise floor
  • children with Downs often have absent OAEs, which may be due to poor ME function of SNHL
  • of OAEs are present, it would be reduced in amplitude depending on:
  • –Small A-B gap
  • –stimulus frequency frequency
  • –amount of effusion
  • DP absence is related to the thickness of the fluid
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13
Q

4 reasons ongoing screening is important

A

1) the inpact of hearing loss in children can adversely affect social development, language acquisition, emotional and psychosocial status, and early pre-academic skills
2) preschool screening allows detection of young children who were missed
3) detect progressive or delayed onset cochlear hearing loss
4) ongoing screening efforts help detecting recurrent conductive hearing loss

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14
Q

OAEs and preschool/school screenings

A
  • hearing screening for preK and school kids is generally pure tone audio with test freqs at 1,2,&4
  • using SNR criteria–too many false negative (misses) for preschool and school age children
  • –DPOAE screening (using a fixed SNR of 6 or greater) can miss up to 38% of children who failed puretone testing
  • using more rigorous criteria for pass outcome:
  • –greater than 6 dB SNR and DP amplitudes above 0 dB SPL
  • –higher false positives leading to more hearing testing, not as costly as infants
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15
Q

OAEs diagnostic value

A
  • offer site-specific info in genetic disorders
  • indicate subclinical dysfunction (risk for HL)
  • combined with other electrophys measures gives more info about where damage is
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16
Q

advantages of OAEs for monitoring

A
  • highly sensitive to cochlear dysfunction because OHCs are first to go
  • OAEs are objective and can be performed on both very young and very sick pts
  • –DPs permit earlier detection
  • –DP measurements yields a high degree of frequency specificity as much as 8-10 frequencies per octave
  • —–not TEs because they arent frequency specific and only go up to about 4kHZ
  • DP info can be obtained for high frequencies
17
Q

problems with OAES for ototoxicity monitoring

A
  • OAES and high freq audio have good agreement, but high freq audio tends to show evidence of ototoxicity earlier
  • OAES are much more affected by middle ear disorders than high freq audio
  • –high prevalence of otitis media in this population
  • therefore battery of OAES, tymps, and high freq audio are necessary for ototoxicity monitoring
18
Q

why monitor for ototoxicity

A
  • prevent permanent HL (DP change of 4-5 dB)
  • medication/dose can be changed when cochlear deficit is observed if possible
  • –also makes family and pt aware of HL
  • use antioxidants and protective agents (glutathione, D-methionine)
19
Q

using OAES for monitoring

A
  • effective and clinically feasible for all age groups
  • sufficient degree of frequency resolution for monitoring
  • for certain drugs (cisplatin) the vast majority of children show significant DP reduction
  • changes in OAES worsen and may persist with ongoing treatment using ototoxic drugs
20
Q

ototoxicity monitoring protocol for OAES

A
  • DPa are recorded and replicated
  • –5-8 frequencies per octave
  • –up to the highest frequency possible
  • –L1 and L2: 65/55, 55/45, 45/35
  • –F2/F1: 1.21
  • NEVER use present or absent only
  • all changes in OAE amplitude must be monitored so medical decisions are not delayed
  • baseline audiological assessment before 1st admin of drug (puretones and high freq, tymps, TE/DPs
  • monitor every week or 2 while drug is being given
  • monitor at 1 wk, 1 month, and 3 months after drug used is discontinued
  • threshold shift criteria (confirmed within 24 hours)
  • –15 dB at one freq or 10 dB at 2 freqs
  • –OAE amplitude reduction of 4-5 dB
21
Q

pseudohypacusis in children

A
  • OAES is an objective test for those who won’t/can’t give valid behavioral responses
  • if findings reveal normal OAEs in the presence of even mild HL
  • –technical issues
  • –subject factors (not understanding task)
  • –pathologic factors (ANSD)
  • –in case of discrepancy, the auditory nerve must be evaluated
  • sudden hearing loss if a re flag
22
Q

pseudohyoacusis in adults

A
  • OAES are an effective lie detector, and save time on invalid test results
  • in study 1 of 5 with pseudo was fit with HAs
  • you always need to deliver the OAE results to the pt for better cooperation
23
Q

autism and OAEs

A
  • an audiological assessment to rule out peripheral hearing loss
  • children with autism generally have normal hearing, but behavioral responses are often unreliable and can be outside the normal region
  • objective measures such as OAEs are particularly important
  • OAEs in combo with ABR or ASSR
24
Q

auditory processing disorder (APD)

A
  • in diagnosis APD, OAEs are particularly useful because they are objective and pre-neural (detect subclinical dysfunction)
  • abnormal peripheral auditory dysfunction may relate to poor response at:
  • –temporal integration and gap detection
  • –hearing in background noise
  • APD patients have abnormal/reduced suppression effect
25
Q

tinnitus and OAEs

A
  • tinnitus is a symptom, not a disease
  • –80% of tinnitus is not related to active disease
  • most tinnitus is related to cochlear dysfunction as a result of aging or NIHL
  • abnormal OAEs are often reported in connection with tinnitus (subclinical)
  • –normal OAEs with tinnitus are rare
  • perceived pitch and OAE test freqs with abnormal results correspond closely (usually tested with DPs not TEs
  • –several points per octave provide more details about OHC function
  • can also provide info about the laterality of tinnitus
  • –unilateral tinnitus with bilaterally abnormal OAEs means they probs have bilateral tinnitus but louder on one side
26
Q

idiopathic SSNHL and OAEs

A
  • permit quick differentiation of sudden SNHL (viral or vascular; site)
  • the presence of normal OAEs shortly after SSNHL can be an indicator for a good outcome, no OAES= poor recovery
  • in those cases where hearing returns, hearing does not seem to return to fully normal unless OAEs also return to normal
  • –if treatment (steroids) are stopped before OAEs return to normal, HL might return
  • –if OAEs are back to normal, the treatment can stop
27
Q

meniere’s disease and OAEs

A
  • conventional theories assume a disruption of the mechanical processes of the cochlea (dampened mobility of the basilar membrane or detachment of the OHCs from the tectorial membrane)
  • most pts have absent or abnormal OAES (TE and DP)
  • –20-30% have completely normal OAEs even in the presence of mild to moderate apparently sensorineural HL
  • –these two completely divergent findings suggests meniere’s disease is actually the result of two different pathological processes
  • some who have been dx with unilateral menieres have OAE abnormalities in both ears, suggesting a bilat pathology
  • glycerol is sometimes used to diagnose meniere’s
  • –1.5ml/kg of body weight is dissolved in equal amount of saline and given orally
  • –changes in OAEs with meniere’s pts include
  • —-increased amplitudes
  • —-decreases in DP thresholds extracted from I/O functions
  • —-increased reproducibility for TEs
28
Q

acoustic neuroma (vestibular schwannoma) and OAEs

A
  • in the internal auditory canal
  • OAEs enhance the detection of site of lesion
  • with small tumors, normal cochlear function and normal OAES are expected, but can be absent OAEs if the tumor is affecting blood flow to cochlea
  • preoperatively, OAES results can play an important role in predicting outcomes
  • –normal OAES= not just preserving hearing after surgery, but higher change for full recovers
  • –abnormal OAES=poor outcome
29
Q

diabetes and OAEs

A
  • some reports have described DP abnormalities in pts with diabetes
  • reduction of DPs even with otherwise normal hearing
  • possibly a metabolic complication of the disease causing this