Week 10: Learning & Memory Flashcards

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1
Q

Learning

A

Process by which experiences change our nervous system and hence our behaviour

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2
Q

Theories of learning

A

Classical Conditioning*
Operant Conditioning*
Perceptual Learning
Relational Learning

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3
Q

classical conditioning

A

all behaviours are acquired through conditioning that occurs through interactions with the environment

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4
Q

operant conditioning

A

the effects of a particular behaviour (i.e., the reinforcers) in a particular situation increase or decrease the probability of the behaviour in the
future
* Modification of voluntary (or “operant”)
behaviours
* Use of punishment (to decrease future behavior) or reinforcement (to increase future behavior)

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5
Q

reinforcement

A

a consequence that causes a behaviour to occur with greater frequency

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6
Q

punishment

A

a consequence that causes a behaviour to occur with decreased frequency

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7
Q

continuous reinforcement

A

The desired behavior is reinforced every
single time it occurs.
● Best used when first learning to create a strong association between the behavior and response.
●E.g., training your dog to sit with biscuits

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8
Q

Intermittent reinforcement

A

Once the response is established. The response is reinforced only part of the time.
●Learned behaviors are acquired more slowly, but the response is more resistant to extinction.

●Fixed-ratio or Variable ratio (# responses)
●Fixed interval or Variable interval (amount of time)

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9
Q

perceptual learning

A
  • Perceptual Learning involves learning to recognize things;
  • It involves perceptual changes from practice or experience.
  • Differentiation; unitization; stimulus imprinting; attentional weighting
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10
Q

relational learning

A
  • Most learning is more complex than simple Stimulus-Response associations
  • Involves learning the temporal and spatial relationships among objects and events
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11
Q

STM VS. LTM

A

●Short-term memory has a limited capacity; long-term memory does not
●Short-term memory fades quickly without rehearsal; long-term memories persist
●Long-term memory can be stimulated with a cue/ hint; retrieval of memories lost from STM do not benefit from the presence of a cue
●STM usually described in more contextual detail than LTM

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12
Q

Long-term memory (LTM)

A
  • LTM: Theoretically unlimited capacity for
    indefinite period of time
  • Physiologically, it is thought that long term
    memories are formed through long-term
    potentiation (LTP)
  • The hippocampus plays a role in converting
    memories from STM to LTM
  • Emotionally significant information is more
    likely to be stored in LTM
  • Locus coeruleus (NE) and DA projection to
    the HC.
  • Flashbulb memories
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13
Q

Engram

A

physical representation of what has been learned

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14
Q

Karl Lashley (1890-1958)

A
  • Reasoned that if memories were connections
    between brain areas, they could be severed
    with a knife
  • Trained rats on mazes and tasks, then made
    cuts to the cortex to try to disrupt performance
  • Findings?
  • Knife cuts did not impair performance
  • Therefore, learning and memory did not depend on
    connections across the cortex
  • Also found that learning did not depend on a single area of the cortex – taking out a chunk of cortex impaired performance, but it was about the chunk taken, not the cortical area itself
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15
Q

Equipotentiality

A

all parts of the cortex contribute
equally to complex functioning behaviors (e.g., learning) and any part can substitute for any other

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16
Q

Mass action

A

the cortex works as a whole, and more cortex is better

17
Q

Brain areas of learning and memory

A

hippocampus
basal ganglia

18
Q

Hippocampus

A
  • Vital for declarative/episodic memory
  • Active during:
    ●Memory formation
    ●Memory recall
    ●Imagining future events
    ●Important for visual spatial memory
19
Q

Cells responsible for spatial memory

A

●Place and Time cells located in the HC = fire in response to spatial locations and temporal information
●Grid cells located in the ERC = hexagonal grid forming a coordinated system that allows for spatial navigation

20
Q

Basal ganglia

A
  • Basal ganglia involved in implicit learning of patterns and habits
  • Implicit learning
  • Striatum = caudate nucleus & putamen
21
Q

Retrograde amnesia

A

Cant remember life before the injury

22
Q

anterograde amnesia

A

Cant make new memories

23
Q

korsakoffs syndrome

A
  • Thiamine deficiency (common in alcoholism)
  • Loss of neural activity throughout the brain, esp. dorsomedial thalamus
  • Hallmark: confabulation (“honest lying”
24
Q

Hebb’s rule

A

“Any two cells or systems of cells that are repeatedly
active at the same time will tend to become ‘associated’, so that activity in one facilitates activity
in the other.”

A basic mechanism for synaptic plasticity wherein an
increase in synaptic efficacy arises from the presynaptic cell’s repeated and persistent
stimulation of the postsynaptic cell.

“Cells that fire together wire together!

25
Q

Long-term potentiation

A

⚫Repeated and persistent stimulation of a
particular synapse makes it more responsive to
new input of the same type = leaving the synapse
potentiated
⚫Potentiation can last minutes, days or weeks
⚫Potential cellular basis of learning and memory

26
Q

Properties of LTP

A
  1. Specificity
    ●Only active synapses onto a cell grow stronger
  2. Cooperativity
    ●2+ axons produce stronger LTP within a dendrite
    than 1 axon
  3. Associativity
    ●The effect of a weak input may be enhanced if
    repeatedly paired with a strong input
27
Q

How does LTP happen at the cellular level?

A
  • Step 1: Binding of Ionotropic receptors
  • Step 2: Chemical reactions in the cell
  • Step 3: Changes in the post-synaptic cell
  • Step 4: Changes in the pre-synaptic cell
28
Q

LTP Step 1: Ionic receptors

A

⚫Glutamate first activates AMPA
receptors, which control the influx of
sodium (Na+) ions into the postsynaptic
cell
⚫NMDA receptors do not respond until
enough AMPA receptors are stimulated
and the neuron is partially depolarized
⚫NMDA receptors at rest have a
magnesium ion (Mg2+) block on their
calcium (Ca2+) channels.
⚫After partial depolarization, the
block is removed and the NMDA
receptor allows Ca2+ to enter in
response to glutamate.
⚫After which both Na+ and Ca2+
enter through the NMDA receptor

29
Q

LTP Step 2: Chemical reactions

A
  • The large Ca2+ influx activates certain protein

CaMKII -> CREB –> Alters gene expression in nucleus
(Amplified by BDNF)
These chemicals are important for LTP to occur

CaMKII: calmodulin-dependent protein kinas
CREB: CAMP response element-binding

30
Q

LTP Step 3: Change in Post-synaptic cell

A
  • Changes in gene expression can create changes in postsynaptic neuron, including:
    1. Building more AMPA receptors on the dendrite, or moving existing AMPA receptors to better positions. Building more branches and spines, creating
    more synapses with the same axon
    2. Attaching phosphate groups to the AMPA receptors to make them more responsive
    3. Building more NMDA receptors

…overall product 🡪 AMPA receptors
stay potentiated

31
Q

LTP Step 4: Change in Pre-synaptic cell

A
  • Strong stimulation of a postsynaptic cell releases a retrograde transmitter that:
  • travels across the synapse
  • alters function in the presynaptic neuron.
  • Usually NO
  • Alterations can include:
    1. decreased threshold for action potential
    2. increased neurotransmitter release
    3. Expanded axon
    4. More transmitter release sites along the axon