Week 1: Introduction Flashcards

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1
Q

Biological Psychology

A

The study of genes, nerves, neurotransmitters, brain circuitry and basic biological processes that underlie behavior.

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2
Q

Aristotle (382-322 BC)

A

Cardiocentric View
- Localization of function is in the heart
- The heart initiates thought and behavior.
- It is the root of intelligence and source of nerves in the body

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3
Q

Hippocrates (430-350 BC)

A

Cephalocentric (Brain) View
Heredity: The child “is healthy when it comes from healthy parts, diseased when it comes from diseased parts”
Homeostasis: Health is primarily that state in which these humors are in the correct proportion to each other, both in strength and quantity, and are well mixed. Pain occurs when one of the substances presents either a deficiency or an excess, or is separated in the body and not mixed with others”

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4
Q

Galen (130 - 200 AD)

A
  • Father of Experimental Physiology
  • First to study the structure of the nervous system through dissection and observation
  • Arteries carry blood, not water, to parts of the body
    -Described valves of the heart
  • Observations around bones, muscles, and nerves
  • Physician to gladiators –prevention through hygiene and nutrition
  • Advanced Hippocrates’ bodily humors theory –Typology of Human Temperament
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5
Q

Rene Descartes (1596 - 1650)

A

Father of Modern Philosophy
- Concept of the Reflex –likened to hydraulics of machines
- The mind affects the body through a brain structure called the pineal gland
- The pineal gland (seat of the soul) is full of animal spirits
- Nerves are hollow tubes allowing flow of “animal spirits” which inflates muscles causing the withdraw movement.
- First systematic account of Mind-Body relationship
Monism: Universe is made up of one substance. Dualism: Mind and body are different kinds of substance that exist independently.
▪Cartesian Dualism: The mind and body are two fundamental, independent substances
▪The mind is invisible –consciousness
▪The body has a physical size that occupies space
▪Non-material soul and a material body
▪The pineal gland is point of contact

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6
Q

Thomas Willis (1621-1675)

A

Founder of Neurology
Comparative anatomist
Assigned behavioral and physiologic functions to the brain
Discovered the Circle of Willis –circle of arteries at base of the brain

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7
Q

Johannes Peter Muller(1801-1858)

A

Physiologist and comparative anatomist
First to experimentally isolate components of the nervous system to see how they function; e.g., distinguishing afferent from efferent fibers Doctrine of Nerve Energies: The nature of perception is defined by the pathway over which the sensory information is carried. The origin of the sensation (i.e., the stimulus) is not important
E.g., optic nerve for seeing versus auditory nerve for hearing

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8
Q

Charles Darwin (1809-1882)

A

Principle of Natural Selection: A process in nature by which only the organisms best adapted to their environment tend to survive and transmit their genetic characters in increasing numbers to succeeding generations while those less adapted tend to be eliminated
➢Principle of functionalism: In order to understand a biological phenomenon, you must understand how it functionally serves the organism

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9
Q

Santiago Ramon Cajal (1852-1934)

A

▪Father of modern Neuroscience
▪Used Golgi stain to demonstrate that cells are separate and do not merely merge into one another ▪Neuron Theory: the relationship between nerve cells is not one of continuity, but rather contiguity ▪Provided detailed description of cell types in the CNS associated with neuronal structures
(Golgi Stain = Silver staining method by Camillo Golgi)

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10
Q

Biological Explanations of Behavior: Evolutionary

A

explains behavior via evolutionary history of the structure/behavior (A evolved from B)

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11
Q

Biological Explanations of Behavior: Functional

A

why a structure or behavior evolved (natural selection).

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12
Q

Biological Explanations of Behavior: Physiological

A

relates behavior to activity of the brain/organs.

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13
Q

Biological Explanations of Behavior: Ontogenetic

A

describes how behavior developed via gene X environment.

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14
Q

How do we correlate brain with behavior?

A

Postmortem dissection
*Examine effects of brain ablation/lesion on behavior
*Correlate brain anatomy with behavior
*Record brain activity during behavior
*Examine effects of brain stimulation on behavior

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15
Q

Postmortem

A

*Importance for confirming disease:
*Probable vs. Definite Alzheimer’s disease: histopathological evidence via autopsy or biopsy
*Evidence for lateralization of behaviour (i.e., language)
*Evidence for sexual dimorphism and behavior (e.g. reproductive behavior)

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16
Q

Ablation/Lesion Studies

A

removing or destroying part of the brain and observing behavior
*Cortical surface technique: suction device
*Subcortical technique using stereotaxic instrument:
*electrical current (radio frequency)
*excitotoxic lesions (compound injected)
*Importance of Sham Lesions
*More precise than lobotomies
*Case Study: HM

17
Q

Imaging to Examine Brain Structure

A

1.) Computerized Axial Tomography (CT/CAT) Scan
*Injection of contrast agent
*3D image created by rotating X-ray scans
*Series of slices that are put together to form a 3-D image

2.) Magnetic Resonance Imaging (MRI)
*Use of static Magnetic field (1.5 Telsa-11T)
*Water molecules (hydrogen atoms) align with the magnetic field
*Add radiofrequency pulse (coils) to perturb oscillation
*Turn pulse off and atoms create ENERGY (radio wave)

18
Q

Imaging to Examine Brain Function

A

Record brain activity during behavior:
1.) Positron emission tomography (PET)
*Injection of radioactive tracer
*Metabolic activity

2.) Electroencephalograph (EEG)
*Record from scalp, low resolution
*Voltage fluctuations –Event Related Potential (ERP)

3.) Functional MRI (fMRI)
*Change in blood flow to activated areas
*Blood oxygenated level dependent (BOLD) response

19
Q

Phrenology

A

Observing and/or feeling the skull to determine an individual’s psychological attributes
*Franz Joseph Gall (18th/19thc)