lecture 10 - bleeding disorders Flashcards
what is the family history assessment for inherited bleeding disorder
family history - check family to see if anyone has it - often runs in the family
what is the symtpom assessment for inherited bleeding disorder
frequent nose bleeds
abnormal bruising
excessive periods women
what is the physical examination for inherited bleeding disorder
petechiae - small/red pruple spots on the skin
ecchymosis - bruising
joint swelling/pain - coagulating factor deficiency
what are inherited platelet disorders
congenital thrombocytopenia
congenital platelet function defect
what is used to diagnose platelet disorders
FBC
blood film
PFA 100
platelet aggregometry
flow
what are the treatments for inherited platelet disorders
desmopressin
platelet transfusions
contraceptive pill for periods
what is VWF disease
genetic bleeding disorder
deficiency of VWF - protein used for blood clotting
how do you catergorise VWD
type 1 - reduced VWF levels
type 2 - abnormal VWF function
type 3 - severe deficiency VWF
what are symtpoms of VWD
type 1 and 2: gum bleeding, brusing, bad periods
type 3: severe haemophilia, joint and muscle bleeds
what is the diagnosis iof VWD
when the VW antigen is low (<30%)
when the VW activity is low
(collagen binding)
when factor VIII is low
mainly O blood group
what are risk factors of VWD
stress
surgery
age
pregnancy
what is treatment for VWD
desmopressin
plasma with VWF
contraceptive pill
what is haemophilia
inherited bleeding disorder
deficiency for factor 8 - HA and factor 9 - HB
worse as it goes down
what is the diagnosis of haemophilia
prolonged coagulation - clotting
normal prothombin time
fibronogen is normal
platelet normal
genetic mutation analysis
treatment for haemophilia
concentrate of factor 8 or 9 if bleeding and before surgery/ head injury
desmopressin injections for mild HA
