Week 1 Neuroanatomy 3 of 4 (6/2 Mo) Flashcards
How to tell an Amide from an Ester?
Esters have one “i” and Amides have two “i”
Patient with atypical pseudocholinesterase have ?
Prolonged duration of action.
If someone has Chronic therapy with acetylcholinesterase inhibitors ( edrophonium, physostigmine, echothiophate) what does it then prolong?
prolongs the action of ester LA.
What is the metabolic end product of ester metabolism that may cause hypersensitivity reation?
Para-aminobenzoic acid (PABA)
Which LA depresses the activity of pseudocholinesterase by 80%?
Dibucaine
Which LA can cause methemoglobinemia?
Prilocaine
If you are giving a patient epinephrine and lidocaine, then the toxic dose of lidocaine becomes?
6mg/kg
sympathetic blockade causes what?
hypotension
tell me the process that causes hypotension due to sympathetic blockade?
vasodilation leads to decreased preload which leads to hypotention.
How do you know when to use phenylephrine over epinephrine?
if beta adrenergic affects are not required add phenylephrine instead of epinephrine.
Tell me six adverse reactions to neuraxial anesthesia?
Urinary retention High block Total spinal anesthesia Cardiac arrest Anterior spinal artery syndrome Horner’s syndrome
Tell me 11 complications related to needle placement of neuraxial anesthesia.
Backache Dural puncture/leak Diplopia Tinnitus Nerve root damage Cauda equina syndrome Bleeding leading to hematoma Inadvertent spinal block Inadvertent intravascular injection Inflammation Infection
Is drug toxicity considered a complication of neuraxial anesthesia?
Yes, drug toxicity is a stand alone complication of neuraxial anesthesia
Explain to me what a high neural block is?
Spinal anesthesia spread towards head causing hypotension, bradycardia and respiratory complications (decreased FRC, dyspnea, inability to cough, apnea)
A high neural block can cause phrenic nerve paralysis, tell me what are your phrenic nerves?
C3, 4, 5
What is the treatment for a high neural block?
Intubation and ventilation Supplemental oxygen Fluid (avoid glucose) Ephedrine for bradycardia Phenylephrine for hypotension
What causes cardiac arrest during spinal anesthesia?
due to increased vagal response and decreased preload
what should you avoid during spinal anesthesia to not have cardiac arrest in your patient?
avoid hypovolemia and do not allow the HR to drop below 50.
hypotension during neuraxial anesthesia is due to what two types of devervation?
sympathetic denervation and pharmacological denervation.
If the LA blocks what levels you are more likely to have urinary retention?
S2,3,4 - leads to loss of micturition reflex.
If you lose micturition reflex you have blocked what level? and what will you do to treat this?
you have blocked the level of S2, 3, 4 and you will need to place a urinary catheter.
what is a fail block and is it considered a complication of neuraxial anesthesia?
yes, it is considered a complication of neuraxial anesthesia. It is when a block was performed but intended effect does not occur, or only partially occurs.
If you accidentally intravenously inject LA, what may occur (S/S)? What type of neuraxial anesthesia is this most often seen with?
Can affect CNS/CVS leading to seizure, unconsciousness, hypotension, arrhythmia and cardiac depression Seen after epidural and caudal block
If you accidentally inject LA into the subdural space what occurs?
rapid CNS depression
Backache associated with neuraxial anesthesia, is it a big deal and how do you treat it?
Mild and self-limiting, treat with NSAIDS.
PDPH: what positioning is it associated with, and what position decreases the likelihood.
increased occurrence while standing or sitting, decreased with lying down.
PDPH: what causes it?
due to leakage of CSF and decreased ICP.
PDPH: Causes what due to traction on CN VI?
diplopia