Week 1-Human Digestive & Absorption, Anatomical Structures and Physiological Structures Flashcards
GIT
The gastrointestinal tract - mouth, esophagus, stomach, small intestine, large intestine, rectum anus
accessory organs - liver, pancreas and gall bladder
Oral Cavity (mouth)
- chewing increases surface area
- when mixed with saliva food becomes bolus
- saliva
Saliva
– Lysozymes: Break down bacteria
– Mucus: Lubricates and holds bolus together
– Salivary amylase: starts breaking down starch
– Lingual lipase: starts breaking down triglycerides
Sphincters
– Lower esophageal sphincter
– Pyloric sphincter
– Sphincter of Oddi
– Ileocecal sphincter (or “valve”) – Anal sphincter
Lower esophageal sphincter
Prevent backflow (reflux) of stomach contents into esophagus
Pyloric sphincter
Control the flow of stomach contents into the small intestine
Sphincter of Oddi
Control the flow of bile from the common bile duct into the small intestine
Ileocecal sphincter
Prevent the contents of the large intestine from reentering the small intestine
Anal sphincters
Prevents defecation until person desires to do so
GIT Motility
- Peristalsis
- Segmentation
- Mass movements
- Elimination via sphincters
Peristalsis
Contractions of the GIT wall muscle for movement of bolus and chyme
• Peristalsis is triggered by the autonomous nervous
system. Hydration and bulk of feces play a role:
stretching of intestinal wall promotes peristalsis
Segmentation
Back and forth movement to allow breaking down
of bolus and chyme into smaller particles so enzymes can access
Mass Movement
Peristalsis over widespread area
Digestion
Process of breaking down foods into molecules that can be absorbed by erythrocytes and delivered into blood and lymphatic system
Absorption
uptake of monomers and micro-nutrients from the lumen of the GIT through absorption cells (enterocytes) into blood or lymph for transport to organs/cells
Ageing= decreased HCL, therefore decreased absorption and digestion
Pathway of food
• Food mixed in the bolus goes through lower
eosophageal sphincter into stomach
• Mixed with stomach secretions becomes chyme
• Pyloric sphincter allows chyme into the small intestine
• Gastric inhibitory peptide (GIP) slows the release of
the chyme from the stomach into the small intestine
Gastrin:
Hormone that controls release of HCl and
pepsinogen
Parietal cells
produce hydrochloric acid (HCl)
HCL
• Denatures proteins
• Destroys bacteria and viruses
• Converts pepsinogen into the active form pepsin:
enzyme for protein digestion
• Aids in minerals absorption
• Chief cells: produce and release gastric lipase
Mucus:
Protects the stomach from “being digested” by HCL
Chief cells
produce and release gastric lipase
Small intestine
• Site of most of the digestive and absorptive processes
• Three sections: duodenum, jejunum and ileum: a total
of 6m in length
• Villi and microvilli on the intestinal wall: increase the
surface area of the lumen by 600 times to optimise the
absorption capacity
Goblet cells:
produce mucus
Endocrine cells
produce hormones
Enterocytes
absorb nutrients and produce
metabolism enzymes