week 1 content Flashcards
phenotype =
karyotype =
- female karyotype _ _ _ _
- male karyotype _ _ _ _
- male with down syndrome karyotype
karyotype – pictorial view of chromosomes; tells number,
structure and sex
- female karyotype – 46XX
- male karyotype – 46XY
- normal karyotype has 23 pairs of autosomes
- male with down syndrome
karyotype – 47 XY +21 (the +21 tells where the extra chromosome is)
phenotype – observable expressions of trait
autosomal dominant disorder -
what would each of these autosomes mean for this disorder
BB
Bb
bb
Has to have at least 1 big B for this disorder to happen
BB - disorder would happen
Bb - disorder would happen
bb - disorder would not happen
autosomal recessive disorder -
what would each of these autosomes mean for this disorder
BB
Bb
bb
Has to have bb for this disorder to happen
BB - disorder would not happen
Bb - would be an asymptomatic carrier
bb - disorder would happen
Umbilical cord
- Connects __ and __
- #__ arteries – carry ____
- # __ vein – carry ______
- Surrounded by _____
- sensory or motor innervation ?
- Twisted/spiral shape due ____
Umbilical cord
- Connects placenta and fetus
- 2 arteries – carry deoxygenated blood and waste from baby to placenta
- 1 vein – oxygenated blood from placenta to baby
- Surrounded by whartons jelly – connective tissue
- No sensory or motor innervation – no pain
- Twisted/spiral shape due to fetal movement
Decrease in normal vaginal flora (natural defense), bacteria overgrowth
Bacterial vaginosis
- Heart beat begins
- Arm and leg buds
- Vertebrae
- Lung buds
- Eyes and ears begin forming
week 4
- Trachea
- Nares
- Liver produces blood cells
- Heart begins circulation of blood
- Digits develop
- Tail recedes
week 6
skin changes
hyper/hypo pigmentation
striae?
chloasma - what and where?
vascular spider nevi?
hair growth i/d
sweat and sebaceous glands i/d
linea nigra - what and where?
- hyperpigmentation
- striae – stretch marks
- facial chloasma – hormonal changes cause darker skin on face, avoid sun
- vascular spider nevi – vascular lesions
- decreased hair growth
- hyperactive sweat and sebaceous glands
- linea nigra - It appears as a dark, vertical line running down the center of your belly, usually from your belly button (umbilicus) to your pubic area, hormonal and normal, resolves itself after pregnancy
positive signs of pregnancy
Signs that are attributed only to the presence of the fetus, can only be caused by pregnancy
- Auscultation of fetal heartbeat
- Fetal movement
- Visualization of the fetus
detected in pregnancy test
hCG –
Enlarged ovaries, many small cysts along outer edge of ovaries
Polycystic ovarian syndrome
uterus changes
uterus size i/d____
fibrous tissue i/d____
blood flow i/d___
what type of contractions?
which way does uterus tilt when pregnant?
- Hypertrophy
- Fibrous tissue increase
- Blood flow increase
- Braxton hicks contractions - also labor contractions, are a normal part of pregnancy that most women experience in the second or third trimester. They are the uterus’ way of preparing for childbirth by tightening and releasing the muscles.
- Not pregnant = posterior tilt
- Pregnant = anterior tilt
eye, cognitive, and metabolic changes
- intraocular pressure i/d
- cornea thickens/thins
- attention, concentration and memory i/d
- water, fat, and protein storage i/d
- fats absorbed i/d
eye, cognitive, and metabolic
- decreased intraocular pressure
- cornea thickens
- decreased attention, concentration and memory
- extra water, fat, and protein are stored
- fats and more completely absorbed
- increase in subq fat
- lanugo disappears
week 36
Cause –
s/s – chancre, wart like lesion on vulva, fever, weight loss, malaise, painless
treatment –
Syphilis
Chronic infection from contact with open wound or acquired congenitally
Cause – spirochete treponema pallidum
s/s – chancre, wart like lesion on vulva, fever, weight loss, malaise, painless
treatment – penicillin
Most common STD
Chlamydial infection
Cause –
s/s – fever, rash on trunk looks like sunburn, vomit, hypotension, inflamed mucus membranes
treatment –
Toxic shock syndrome
Cause – toxin release by staph A
s/s – fever, rash on trunk looks like sunburn, vomit, hypotension, inflamed mucus membranes
treatment – hospitalization, IVF to maintain BP, antibiotics
Cause –
s/s – thin, purulent discharge, dysuria, lower abd pain
treatment –
Chlamydial infection
Most common STD
increases risk for PID
Cause – chlamydia trachomatis
s/s – thin, purulent discharge, dysuria, lower abd pain
treatment – azithromycin
breast changes
hyperplasia or hypertrophy
areolae darken/lighten
veins more/less prominent
striae
secretes what?
- Glandular hyperplasia AND hypertrophy
- Areolae darken, superficial veins prominent
- Striae – stretch marks
- Colostrum secretion
twins - identical (di/di, mono/di, mono/mono) vs fraternal (di/di)
- 2 separate eggs
- Fertilized by 2 different sperm
- 2 separate placentas, chorions, and amnions
Fraternal – di/di
cervix changes
mucous plug
goodells sign
chadwicks sign
hegards sign
- Mucous plug – barrier in the cervix blocks bacteria from entering uterus and reaching fetus
- Goodell’s sign – softening cervix
- Chadwicks sign – blue cervix b/c of increased vascularity
- Hegars sign – soft uterus
what type of sign of pregnancy?
Amenorrhea
- n/v
- excessive fatigue
- urinary frequency
- breast changes
- quickening
presumptive
Changes experienced and reported by the woman that suggest the possibility of pregnancy but can also be caused by conditions other than pregnancy
Subjective
Dominant vs. Recessive Alleles:
2 copies needed
25% chance
only one copy needed
50% chance
Dominant vs. Recessive Alleles:
* Dominant: In autosomal dominant inheritance, only one copy of the altered gene (dominant allele) is needed from a parent to cause the trait or condition to appear in the offspring. 50%
* Recessive: In autosomal recessive inheritance, two copies of the altered gene (recessive allele) are needed, one from each parent, for the trait or condition to manifest. A normal gene (dominant allele) will mask the effect of the recessive allele. 25%
recessive
dominant vs recessive
- affected individual has affected parent
- affected individual have 50% chance of passing defect to their kids and 50% of not passing the defect to their kids
- parent may have mild form of disease and child may have severe form
- examples – Huntington’s disease, dwarfism, polydactyly
dominant
dominant vs recessive
- affected individual has clinically normal parents, but both are carriers
- when both parents are carriers
- 25% chance of having the recessive disorder
- 50% chance of being a healthy carrier
- 25% chance of being healthy and not a carrier
- Example – Cystic fibrosis
- BOTH PARENT MUST BE CARRIERS – if one parent is carrier and other parent is not a carrier/doesn’t have CF = there is a 0% chance the child will have CF bc it needs the gene from both parents
recessive
- Face well developed
- Eye lids close
- Tooth buds
- Genitals are well differentiated
- Urine is produced
- Spontaneous movement
- fetal heart tones can be heard with doppler
week 12
- male have an extra X chromosome
- 47 XXY (should be 46 XY but there is an extra X chromosome)
- s/s
- small testicles
- decreased testosterone
- less muscle mass
- decreased body hair
- enlarged breast tissue
- little to no sperm
kleinfelter syndrome
dominant
hormones give female characteristics
hormones stabilize uterus, lactation
hormones relaxes and constricts smooth muscle
hormone helps eggs to mature
Estrogens – female characteristics
Progesterone – stabilize uterus, lactation
Prostaglandins – relaxes and constricts smooth muscle
FSH – hormone helps eggs to mature
Uterine size - Fundal height AKA McDonald’s method
for EDB
- It measures the distance from the top of the mother’s pubic symphysis (the bony junction in the front of the pelvis) to the top of her uterus.
- The rule states that the fundal height should be roughly equal to the number of weeks pregnant, with a plus or minus 2 cm allowance for some variation.
- Can only use this method 20 weeks or later
- If there is more than a 2cm difference = investigate!
- full term starts at 37 weeks
- skin smooth and polished
- vernix in creases and folds only
- head bigger than chest
week 38
recommended weight gain
based on pre-pregnancy BMI
- underweight pre preg = gain ?
- normal weight pre preg = gain ?
- overweight pre preg = gain ?
- obese pre preg = gain ?
recommended weight gain
based on pre-pregnancy BMI
- underweight pre preg = gain 28-40 lbs
- normal weight pre preg = gain 25-35 lbs
- overweight pre preg = gain 15-25 lbs
- obese pre preg = gain 11-20 lbs
gaining weight pattern
- 1st trimester – gain ?
- 2nd and 3rd trimester – gain ?
gaining weight pattern
- 1st trimester – gain 1-5 lbs total
- 2nd and 3rd trimester – gain about 1 lb per week
what is the normal variance for Uterine size - Fundal height AKA McDonald’s method for EBD
what gestation age can you start using this method
+ or - 2 cm
20 weeks or later
STI
Cause
s/s – yellow/green discharge, inflammation, itching, dysuria
treatment -
Trichomoniasis
STI
Cause – trichomoniasis vaginalis
s/s – yellow/green discharge, inflammation, itching, dysuria
treatment - flagyl/metronidazole
___________ ___________
___________ infection
Cause – (4)
s/s – thick vaginal discharge, itching, rash
treatment – (2)
Vaginal candidiasis
Yeast infection
Cause – antibiotics, oral contraceptives, immunosuppressants, DM
s/s – thick vaginal discharge, itching, rash
treatment – Diflucan/fluconazole or nystatin
Chronic infection from contact with open wound or acquired congenitally
Syphilis
anterior of uterus, muscular upper portion of the uterus
posterior of uterus
area around the cervix where semen can pool/collect
Fundus of the uterus –
Cervix –
posterior fornix –
musculoskeletal changes
- pelvic joints loosen/tighten
- change in center of gravity?
- separation of rectus abdominus?
- postural change – lordosis/kyphosis?
musculoskeletal
- pelvic joints relax
- change in center of gravity
- separation of rectus abdominus
- postural change – lordosis
- egg removed by laparoscopy and placed with sperm
- fertilization occurs in fallopian tube
- then egg travels naturally to uterus to implant
gamete intrafallopian transfer
1 – cold sore
2 – genital infection
Herpes genitalis
HSV 1 – cold sore
HSV 2 – genital infection