Week 1 Flashcards
Neuron cell bodies size
15-20 um
Nissl bodies size
50 um
Gap/synapses between motor neuron vs membrane of muscle fibre
30-50nm
oligodendrocyte size
10 20 um
grey matter contains
soma, dendrites, axon terminal, synapses, glia
white matter contains
mylinated axon + glia
grey matter function
intergration of information
white matter function
- impulses propagate here
- information travel here
rER stands for?
rough endoplasmic reticulum
rER aslo called?
nissl body
rER important
protein synthesis
Neuron types
- sensory vs motor
- projection or stay still
sensory neuron
- bipolar, pseudounipolar (split)
- receive sensory information
short, stay within the local area
interneuron
golgi type 2
projection motor
long, out of brain and spinal cord (multipolar)
golgi type 1
contain cell bodies outside CNS
dorsal ganglion
action potential
membrane is polarised
inside more negative
type of input action potential
chemical: neurotransmitter
mechanical: pressure/ stretch of receptors at nerve ending in skin/muscle/bbb
thermal: thermo receptor
special sensory: taste. light proton…
speed with myelin vs without
12-130 vs 0.5 - 2 (m/s)
gap between motor neuron and plasma membrane
30 - 50 nm
motor neuron support how many muscle cell
3 to 100
neuroplasticity
change in shape + function + connection
Cells in nervous system
glia
neuron
endothelial
glia include
astrocyte
oligodendrocyte
microglia
endothelial cell associates with
blood supply, supporting BBB
CNS contains cells:
neuron
glia (oligodendrocyte, microglia, astrocyte)
endothelial
PNS contains cells:
satelite cells
schwann cells
myelinating cells
schwann + oligodendrocytes
myelin sheath
fatty insulating layer
myelinated axon
motor to skeletal muscle, sensory fine touch fromskin, proprioceptors body position
unmyelinated axon
sensory pain from skin, motor heart + blood vessel
neurilemma
outermost section of schwann cells surrounding axon
oligodendrocyte
myelinate many axon
schwann
need various to myelinate one
astrocyte func
- metabolic support for bbb
- structural support for cns (brain + spinal cord)
- endothelium for tight junction bbb (not tight only endothelial)
- biochemical balance neuron (lactate)
- scar (fill where neuron die)
- support synapses form(buffer K+ prevent synaptic dysfunc)
- glutamine for synthesis
microglia
immune (survey CNS for pathogen)
injury: repair
prune synapses remodelling adult brain
tile grey matter
laser injury hippocampus
injury retina
change shape activate shorten thicken
phagocytosis
find eat digest
ependymal cells
creating cerebrospinal fluid
PNS satellite cells
surround neuron in
- sensory
- sympathetic
- parasympathetic
- ganglia
- regulate chemical environment
myelin stain view?
oligodendrocyte bodies
golgi silver stain
full morphology of neuron
include dendritic arbor + axon
immunohistochemistry
distinguish diverse cell types
neuron vs glia
different glia
morphology
shape of cells
morphology types
bipolar, multipolar, unipolar..