lab pharmacoloty w4 Flashcards
drug actions can be consider in term of selectivity, affinity, potency, and efficacy.
Selectivity is?
how well the drug act on what it binds to
(drug binds into receptors that it is not designed for -> low selectivity)
affinity is?
how easy a drug can bind into a receptor
eg with low concentration a drug is able to bind into a receptor
-> high affinity
potency is?
the concentration of drug to have a specified effect
low concentration-> have an effect
-> high potency
efficacy is?
ability a drug to produce response (the maximal effect) after binding
graded potential
when charge added up at post synaptic membrane and reach threshold
quarternary amine
Ach
amino acid
gaba and glycine, glutamate
ionotropic
ligand gated
metabotropic
g protein coupled
ligand gated mediate tranmission
directly
g protein modulate transmission
via second messenger
mao degrade both cytoplasmic and vesicle stores of monoamine
true or false
false
degrade cytoplasmic only
do Na+/K+ ATPase innitiate action potential
NO
myelin is secreted from oligodendrocyte true or false?
FALSE
IT IS PART OF OLIGODENDROCYTE
MICROGLIA ALSO SIGNALLING MOLECULES
Some other jobs of astrocyte
REUPTAKE
communicate with other astrocyte control ion concentration in extracellular fluid
