Wednesday - fitz - therapeutic proteins

Question 1

right before the “MAB” in monoclonal antibodies, these mean what:

u
o
xi
zu

Answer 1

u - human
o - mouse
xi - chimeric
zu- humanized

Question 2

right after the name that the drug company gave the monoclonal antibodies, what do these mean

vir
bac
lim
les
cir

Answer 2

vir - virus
bac - bacteria
lim - immune system
les - infectious lesion
cir - cardiovascular

Question 3

serum sickness

Answer 3

worst outcome of type 3 hypersensitivity reaction

patients own immune system is generating antibodies against the MAB’s that you give them in this case.

happens 7-10 days after the administration.

proteins accumulate in the liver

Question 4

can you see type 1 hypersensitivity reactions when giving MABs?

Answer 4

ye

called an infusion reaction

Question 5

HAMA response

Answer 5

human antimouse antibody response.

your body rejects the MABs with an -o- in the middle

Question 6

cytokine:
Erythropoietin

stimulates formation of what’side effects

Answer 6

erythrocytes from erythroid progenitor cells

hypertension, thrombosis

Question 7

cytokine:
Filgramostim

stimulates formation of what
mimics what cytokine

SE

Answer 7

formation of neutrophils

mimics g-csf

SE: bone pain, splenic rupture

Question 8

cytokine:
interleukin 11

stimulates formation of what cells

SE

Answer 8

megakaryocytes

SE: atrial fibrillation

Question 9

cytokine:
sargramostim

stimulates formation of what cells

mimics what cytokine

SE

Answer 9

all myelocytes, especially neutrophils and monocytes

mimics GM-csf

this one has more side effects that other growth factors because it is less specific

SE: bone pain, capillary leak syndrome