Wednesday Fitz - antineoplastic drugs

Question 1

What drugs work especially well with cancers that involve a p53 mutation?

Answer 1

alkylating agents

Question 2

what drug took the success rate of testicular cancer and bumped it from ~5 percent to ~85 percent

Answer 2

cisplatin

Question 3

what is the major dose-limiting complication in cancer tx with cytotoxic drugs/

Answer 3

bone marrow suppression

Question 4

Major reason from non compliance with cytotoxic Tx

Answer 4

nausia and vomiting

Question 5

radiation recall reaction

Answer 5

desquamation (loss of skin) at sites of previous radiation

Question 6

Two types of CCS cancer drugs

Answer 6

G2/M - plant alkaloids

S - antimetabolites

good against cancers with a high growth fraction (they are growing a lot)

Question 7

what is upregulated in multidrug resistance as far as exporting the drug is concerned

Answer 7

P-glycoprotein -

ATP dependant protein. pumps drugs out of the cell

(MDR 1-9 genes)