Friday - krafts 3 - Lymphoblastic Leukemia

Question 1

Enzyme in lymphoblasts that you check for in order to diagnose leukemia

Answer 1

TdT

Question 2

T-ALL

hallmarks

Answer 2

T-lymphoblastic leukemia = T-lymphoblastic lymphoma
TdT+, CD3 pos
teenage male with mediastinal mass (thymus)
WBC ^^^
Bad prognosis

Question 3

B-ALL

hallmarks

Answer 3

b-lymphoblastic leukemia = b-lymphoblastic lymphoma
TdT+, CD19,20,21 pos
Rarely philedelphia chromosome 9:22 positive (Ph+) means worse prognosis
better prognosis that T-ALL

Question 4

ALL

Tx

Answer 4

Chemo
sometimes marrow transplant (rare)
many are cured

Question 5

ALL

epidemiology
prognosis

Answer 5

more common in children (ALL until proven AML)
prognosis is often good

prognosis:
T type - worse
younger -better
WBC less that 50,000 - better
hyperdiploidy - better